|
|
eF-site ID
|
4pcf-A |
|
PDB Code
|
4pcf |
|
Chain
|
A |
|
click to enlarge
|
|
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Title
|
Structure-based protein engineering of a monomeric triosephosphate isomerase towards changing substrate specificity |
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Classification
|
ISOMERASE |
|
Compound
|
Ma18-TIM |
|
Source
|
(4PCF) |
|
|
Sequence
|
A: |
SKPQPIAAANWKSSLSGLIDLFNSTSINHDVQCVVASTFV
HLAMTKERLSHPKFVIAAQNAGNTDALASLKDFGVNWIVL
GHFERRWYYGETNEIVADKVAAAVASGFMVIACIGETLQE
RESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEPVWAIG
TGKVVTPQQAQEAHALIRSWVSSKIGADVAGELRILYGGS
VNGKNARTLYQQRDVNGFLAGLKPEFVDIIKATQ
|
|
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Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
11 |
| type |
BINDING |
| sequence |
N
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
2)
|
chain |
A |
| residue |
13 |
| type |
BINDING |
| sequence |
K
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
3)
|
chain |
A |
| residue |
103 |
| type |
ACT_SITE |
| sequence |
G
|
| description |
Electrophile
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
A |
| residue |
175 |
| type |
ACT_SITE |
| sequence |
G
|
| description |
Proton acceptor
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
A |
| residue |
165-175 |
| type |
prosite |
| sequence |
AYEPVWAIGTG
|
| description |
TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG
|
| source |
prosite : PS00171
|
|
|
|