eF-site ID 4pce-A
PDB Code 4pce
Chain A

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Title Crystal Structure of the first bromodomain of human BRD4 in complex with compound B13
Classification Transcription/transcription Inhibitor
Compound Bromodomain-containing protein 4
Source Homo sapiens (Human) (BRD4_HUMAN)
Sequence A:  SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAW
PFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWN
AQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI
NELPTEE
Description


Functional site

1) chain A
residue 100
type
sequence I
description binding site for residue EDO A 301
source : AC1

2) chain A
residue 101
type
sequence I
description binding site for residue EDO A 301
source : AC1

3) chain A
residue 102
type
sequence K
description binding site for residue EDO A 301
source : AC1

4) chain A
residue 103
type
sequence T
description binding site for residue EDO A 301
source : AC1

5) chain A
residue 135
type
sequence N
description binding site for residue EDO A 301
source : AC1

6) chain A
residue 81
type
sequence W
description binding site for residue 2N0 A 302
source : AC2

7) chain A
residue 99
type
sequence K
description binding site for residue 2N0 A 302
source : AC2

8) chain A
residue 140
type
sequence N
description binding site for residue 2N0 A 302
source : AC2

9) chain A
residue 146
type
sequence I
description binding site for residue 2N0 A 302
source : AC2

10) chain A
residue 80-139
type prosite
sequence AWPFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYY
WNAQECIQDFNTMFTNCYIY
description BROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
source prosite : PS00633

11) chain A
residue 140
type SITE
sequence N
description Acetylated histone binding => ECO:0000269|PubMed:22464331
source Swiss-Prot : SWS_FT_FI1

12) chain A
residue 99
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
source Swiss-Prot : SWS_FT_FI2


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