|
eF-site ID
|
4pc8-A |
PDB Code
|
4pc8 |
Chain
|
A |
|
click to enlarge
|
|
Title
|
Structure-based protein engineering efforts on the scaffold of a monomeric triosephosphate isomerase yielding a sugar isomerase |
Classification
|
ISOMERASE |
Compound
|
Ma21-TIM |
Source
|
(4PC8) |
|
Sequence
|
A: |
MSKPQPIAAANWKSGSPDSLSELIDLFNSTSINHDVQCVV
ASTFVHLAMTKERLSHPKFVIAALNAGNADALASLKDFGV
NWIVLGHSERRWYYGETNEIVADKVAAAVASGFMVIACIG
ETLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEP
VWAIGTGKVATPQQAQEAHALIRSWVSSKIGADVAGELRI
LYGGSVNGKNARTLYQQRDVNGFLAGLKPEFVDIIKATQ
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
171 |
type |
|
sequence |
A
|
description |
binding site for residue GOA A 301
|
source |
: AC1
|
|
2)
|
chain |
A |
residue |
173 |
type |
|
sequence |
G
|
description |
binding site for residue GOA A 301
|
source |
: AC1
|
|
3)
|
chain |
A |
residue |
213 |
type |
|
sequence |
S
|
description |
binding site for residue GOA A 301
|
source |
: AC1
|
|
4)
|
chain |
A |
residue |
165-175 |
type |
prosite |
sequence |
AYEPVWAIGTG
|
description |
TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG
|
source |
prosite : PS00171
|
|
5)
|
chain |
A |
residue |
95 |
type |
ACT_SITE |
sequence |
H
|
description |
Electrophile
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
6)
|
chain |
A |
residue |
167 |
type |
ACT_SITE |
sequence |
E
|
description |
Proton acceptor
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
7)
|
chain |
A |
residue |
11 |
type |
BINDING |
sequence |
N
|
description |
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
8)
|
chain |
A |
residue |
13 |
type |
BINDING |
sequence |
K
|
description |
|
source |
Swiss-Prot : SWS_FT_FI3
|
|
|
|