eF-site ID 4pc8-A
PDB Code 4pc8
Chain A

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Title Structure-based protein engineering efforts on the scaffold of a monomeric triosephosphate isomerase yielding a sugar isomerase
Classification ISOMERASE
Compound Ma21-TIM
Source (4PC8)
Sequence A:  MSKPQPIAAANWKSGSPDSLSELIDLFNSTSINHDVQCVV
ASTFVHLAMTKERLSHPKFVIAALNAGNADALASLKDFGV
NWIVLGHSERRWYYGETNEIVADKVAAAVASGFMVIACIG
ETLQERESGRTAVVVLTQIAAIAKKLKKADWAKVVIAYEP
VWAIGTGKVATPQQAQEAHALIRSWVSSKIGADVAGELRI
LYGGSVNGKNARTLYQQRDVNGFLAGLKPEFVDIIKATQ
Description


Functional site

1) chain A
residue 171
type
sequence A
description binding site for residue GOA A 301
source : AC1

2) chain A
residue 173
type
sequence G
description binding site for residue GOA A 301
source : AC1

3) chain A
residue 213
type
sequence S
description binding site for residue GOA A 301
source : AC1

4) chain A
residue 165-175
type prosite
sequence AYEPVWAIGTG
description TIM_1 Triosephosphate isomerase active site. AYEPVWAIGTG
source prosite : PS00171

5) chain A
residue 95
type ACT_SITE
sequence H
description Electrophile
source Swiss-Prot : SWS_FT_FI1

6) chain A
residue 167
type ACT_SITE
sequence E
description Proton acceptor
source Swiss-Prot : SWS_FT_FI2

7) chain A
residue 11
type BINDING
sequence N
description
source Swiss-Prot : SWS_FT_FI3

8) chain A
residue 13
type BINDING
sequence K
description
source Swiss-Prot : SWS_FT_FI3


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