eF-site ID 4pan-A PDB Code 4pan Chain A click to enlarge Title A conserved phenylalanine as relay between the 5 helix and the GDP binding region of heterotrimeric G protein Classification SIGNALING PROTEIN Compound Guanine nucleotide-binding protein G(i) subunit alpha-1 Source (GNAI1_RAT) Sequence A:  DKAAVERSKMIDRNLREDGEKAAREVKLLLLGAGESGKST IVKQMKIIHEAGYSEEECKQYKAVVYSNTIQSIIAIIRAM GRLKIDFGDAARADDARQLFVLAGAAEEGFMTAELAGVIK RLWKDSGVQACFNRSREYQLNDSAAYYLNDLDRIAQPNYI PTQQDVLRTRVKTTGIVETHFTFKDLHFKMFDVGVTAIIF CVALSDYDLNRMHESMKLFDSICNNKWFTDTSIILFLNKK DLFEEKIKKSPLTICYPEYAGSNTYEEAAAYIQCQFEDLN KRKDTKEIYTHFTCATDTKNVQFVYDAVTDVIIKNNLKDC GLF Description Functional site 1) chain A residue 41 type sequence A description binding site for residue GDP A 401 source : AC1 2) chain A residue 43 type sequence E description binding site for residue GDP A 401 source : AC1 3) chain A residue 44 type sequence S description binding site for residue GDP A 401 source : AC1 4) chain A residue 45 type sequence G description binding site for residue GDP A 401 source : AC1 5) chain A residue 46 type sequence K description binding site for residue GDP A 401 source : AC1 6) chain A residue 47 type sequence S description binding site for residue GDP A 401 source : AC1 7) chain A residue 48 type sequence T description binding site for residue GDP A 401 source : AC1 8) chain A residue 151 type sequence S description binding site for residue GDP A 401 source : AC1 9) chain A residue 175 type sequence L description binding site for residue GDP A 401 source : AC1 10) chain A residue 176 type sequence R description binding site for residue GDP A 401 source : AC1 11) chain A residue 177 type sequence T description binding site for residue GDP A 401 source : AC1 12) chain A residue 178 type sequence R description binding site for residue GDP A 401 source : AC1 13) chain A residue 269 type sequence N description binding site for residue GDP A 401 source : AC1 14) chain A residue 270 type sequence K description binding site for residue GDP A 401 source : AC1 15) chain A residue 272 type sequence D description binding site for residue GDP A 401 source : AC1 16) chain A residue 273 type sequence L description binding site for residue GDP A 401 source : AC1 17) chain A residue 325 type sequence C description binding site for residue GDP A 401 source : AC1 18) chain A residue 326 type sequence A description binding site for residue GDP A 401 source : AC1 19) chain A residue 327 type sequence T description binding site for residue GDP A 401 source : AC1 20) chain A residue 15 type sequence R description binding site for residue SO3 A 402 source : AC2 21) chain A residue 21 type sequence R description binding site for residue SO3 A 402 source : AC2 22) chain A residue 32 type sequence R description binding site for residue SO3 A 402 source : AC2 23) chain A residue 180 type sequence K description binding site for residue SO3 A 402 source : AC2 24) chain A residue 43 type sequence E description binding site for residue CL A 403 source : AC3 25) chain A residue 150 type sequence D description binding site for residue CL A 403 source : AC3 26) chain A residue 178 type sequence R description binding site for residue CL A 403 source : AC3 27) chain A residue 270 type sequence K description binding site for residue CL A 403 source : AC3 28) chain A residue 43 type catalytic sequence E description 533 source MCSA : MCSA1 29) chain A residue 48 type catalytic sequence T description 533 source MCSA : MCSA1 30) chain A residue 178 type catalytic sequence R description 533 source MCSA : MCSA1 31) chain A residue 200 type catalytic sequence D description 533 source MCSA : MCSA1 32) chain A residue 43 type BINDING sequence E description BINDING => ECO:0007744|PDB:1AS0, ECO:0007744|PDB:1BH2, ECO:0007744|PDB:1GIA, ECO:0007744|PDB:1GIL, ECO:0007744|PDB:3FFA, ECO:0007744|PDB:4N0D, ECO:0007744|PDB:4PAO, ECO:0007744|PDB:4PAQ source Swiss-Prot : SWS_FT_FI1 33) chain A residue 175 type BINDING sequence L description BINDING => ECO:0007744|PDB:1AS0, ECO:0007744|PDB:1BH2, ECO:0007744|PDB:1GIA, ECO:0007744|PDB:1GIL, ECO:0007744|PDB:3FFA, ECO:0007744|PDB:4N0D, ECO:0007744|PDB:4PAO, ECO:0007744|PDB:4PAQ source Swiss-Prot : SWS_FT_FI1 34) chain A residue 200 type BINDING sequence D description BINDING => ECO:0007744|PDB:1AS0, ECO:0007744|PDB:1BH2, ECO:0007744|PDB:1GIA, ECO:0007744|PDB:1GIL, ECO:0007744|PDB:3FFA, ECO:0007744|PDB:4N0D, ECO:0007744|PDB:4PAO, ECO:0007744|PDB:4PAQ source Swiss-Prot : SWS_FT_FI1 35) chain A residue 269 type BINDING sequence N description BINDING => ECO:0007744|PDB:1AS0, ECO:0007744|PDB:1BH2, ECO:0007744|PDB:1GIA, ECO:0007744|PDB:1GIL, ECO:0007744|PDB:3FFA, ECO:0007744|PDB:4N0D, ECO:0007744|PDB:4PAO, ECO:0007744|PDB:4PAQ source Swiss-Prot : SWS_FT_FI1 36) chain A residue 47 type BINDING sequence S description BINDING => ECO:0000269|PubMed:25037222, ECO:0000269|PubMed:9705312, ECO:0007744|PDB:1BH2, ECO:0007744|PDB:4PAO source Swiss-Prot : SWS_FT_FI2 37) chain A residue 150 type BINDING sequence D description BINDING => ECO:0007744|PDB:1AS0, ECO:0007744|PDB:1BH2, ECO:0007744|PDB:1GIL, ECO:0007744|PDB:4N0D source Swiss-Prot : SWS_FT_FI3 38) chain A residue 181 type BINDING sequence T description BINDING => ECO:0000269|PubMed:19703466, ECO:0000269|PubMed:25037222, ECO:0000269|PubMed:9705312, ECO:0007744|PDB:1BH2, ECO:0007744|PDB:4PAO source Swiss-Prot : SWS_FT_FI4 39) chain A residue 326 type BINDING sequence A description BINDING => ECO:0007744|PDB:1AS0, ECO:0007744|PDB:1GIA, ECO:0007744|PDB:1GIL, ECO:0007744|PDB:3FFA, ECO:0007744|PDB:4N0D, ECO:0007744|PDB:4PAO, ECO:0007744|PDB:4PAQ source Swiss-Prot : SWS_FT_FI5

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