eF-site ID 4p6x-ABCDEFGHIJKL PDB Code 4p6x Chain A, B, C, D, E, F, G, H, I, J, K, L click to enlarge Title Crystal Structure of cortisol-bound glucocorticoid receptor ligand binding domain Classification HORMONE RECEPTOR/HORMONE ACTIVATOR Compound Glucocorticoid receptor Source (NCOA2_HUMAN) Sequence A:  PQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTTLNM LGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMALMA FALGWRSYRQSSANLLYFAPDLIINEQRMTLPCMYDQCKH MLYVSSELHRLQVSYEEYLCMKVLLLLSTIPKDGLKSQAL FDAIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLLDSM HEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIPKYS NGNIKKLLFHQK B:  NALLRYLLDKDD C:  ATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTT LNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMA LMAFALGWRSYRQSSANLLYFAPDLIINEQRMTLPCMYDQ CKHMLYVSSELHRLQVSYEEYLCMKVLLLLSTIPKDGLKS QALFDAIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLL DSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIP KYSNGNIKKLLFHQK D:  KENALLRYLLDKDD E:  ATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTT LNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMA LMAFALGWRSYRQSSANLLYFAPDLIINEQRMTLPCMYDQ CKHMLYVSSELHRLQVSYEEYLCMKVLLLLSTIPKDGLKS QALFDAIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLL DSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIP KYSNGNIKKLLFHQK F:  KENALLRYLLDKDD G:  ATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTT LNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMA LMAFALGWRSYRQSSANLLYFAPDLIINEQRMTLPCMYDQ CKHMLYVSSELHRLQVSYEEYLCMKVLLLLSTIPKDGLKS QALFDAIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLL DSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIP KYSNGNIKKLLFHQ H:  ENALLRYLLDKDD I:  ATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTT LNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMA LMAFALGWRSYRQSSANLLYFAPDLIINEQRMTLPCMYDQ CKHMLYVSSELHRLQVSYEEYLCMKVLLLLSTIPKDGLKS QALFDAIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLL DSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIP KYSNGNIKKLLFHQK J:  NALLRYLLDKDD K:  ATLPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSTWRIMTT LNMLGGRQVIAAVKWAKAIPGFRNLHLDDQMTLLQYSWMA LMAFALGWRSYRQSSANLLYFAPDLIINEQRMTLPCMYDQ CKHMLYVSSELHRLQVSYEEYLCMKVLLLLSTIPKDGLKS QALFDAIRMTYIKELGKAIVKREGNSSQNWQRFYQLTKLL DSMHEVVENLLNYCFQTFLDKTMSIEFPEMLAEIITNQIP KYSNGNIKKLLFHQK L:  KENALLRYLLDKDD Description Functional site 1) chain A residue 563 type sequence L description binding site for residue HCY A 900 source : AC1 2) chain A residue 564 type sequence N description binding site for residue HCY A 900 source : AC1 3) chain A residue 570 type sequence Q description binding site for residue HCY A 900 source : AC1 4) chain A residue 604 type sequence M description binding site for residue HCY A 900 source : AC1 5) chain A residue 611 type sequence R description binding site for residue HCY A 900 source : AC1 6) chain A residue 623 type sequence F description binding site for residue HCY A 900 source : AC1 7) chain A residue 642 type sequence Q description binding site for residue HCY A 900 source : AC1 8) chain A residue 735 type sequence Y description binding site for residue HCY A 900 source : AC1 9) chain A residue 736 type sequence C description binding site for residue HCY A 900 source : AC1 10) chain A residue 739 type sequence T description binding site for residue HCY A 900 source : AC1 11) chain A residue 747 type sequence I description binding site for residue HCY A 900 source : AC1 12) chain C residue 563 type sequence L description binding site for residue HCY C 900 source : AC2 13) chain C residue 564 type sequence N description binding site for residue HCY C 900 source : AC2 14) chain C residue 570 type sequence Q description binding site for residue HCY C 900 source : AC2 15) chain C residue 604 type sequence M description binding site for residue HCY C 900 source : AC2 16) chain C residue 611 type sequence R description binding site for residue HCY C 900 source : AC2 17) chain C residue 623 type sequence F description binding site for residue HCY C 900 source : AC2 18) chain C residue 642 type sequence Q description binding site for residue HCY C 900 source : AC2 19) chain C residue 735 type sequence Y description binding site for residue HCY C 900 source : AC2 20) chain C residue 736 type sequence C description binding site for residue HCY C 900 source : AC2 21) chain C residue 739 type sequence T description binding site for residue HCY C 900 source : AC2 22) chain C residue 747 type sequence I description binding site for residue HCY C 900 source : AC2 23) chain E residue 563 type sequence L description binding site for residue HCY E 900 source : AC3 24) chain E residue 564 type sequence N description binding site for residue HCY E 900 source : AC3 25) chain E residue 570 type sequence Q description binding site for residue HCY E 900 source : AC3 26) chain E residue 611 type sequence R description binding site for residue HCY E 900 source : AC3 27) chain E residue 623 type sequence F description binding site for residue HCY E 900 source : AC3 28) chain E residue 642 type sequence Q description binding site for residue HCY E 900 source : AC3 29) chain E residue 735 type sequence Y description binding site for residue HCY E 900 source : AC3 30) chain E residue 736 type sequence C description binding site for residue HCY E 900 source : AC3 31) chain E residue 739 type sequence T description binding site for residue HCY E 900 source : AC3 32) chain E residue 747 type sequence I description binding site for residue HCY E 900 source : AC3 33) chain G residue 563 type sequence L description binding site for residue HCY G 900 source : AC4 34) chain G residue 564 type sequence N description binding site for residue HCY G 900 source : AC4 35) chain G residue 570 type sequence Q description binding site for residue HCY G 900 source : AC4 36) chain G residue 604 type sequence M description binding site for residue HCY G 900 source : AC4 37) chain G residue 611 type sequence R description binding site for residue HCY G 900 source : AC4 38) chain G residue 623 type sequence F description binding site for residue HCY G 900 source : AC4 39) chain G residue 642 type sequence Q description binding site for residue HCY G 900 source : AC4 40) chain G residue 735 type sequence Y description binding site for residue HCY G 900 source : AC4 41) chain G residue 736 type sequence C description binding site for residue HCY G 900 source : AC4 42) chain G residue 739 type sequence T description binding site for residue HCY G 900 source : AC4 43) chain G residue 747 type sequence I description binding site for residue HCY G 900 source : AC4 44) chain I residue 563 type sequence L description binding site for residue HCY I 900 source : AC5 45) chain I residue 564 type sequence N description binding site for residue HCY I 900 source : AC5 46) chain I residue 570 type sequence Q description binding site for residue HCY I 900 source : AC5 47) chain I residue 604 type sequence M description binding site for residue HCY I 900 source : AC5 48) chain I residue 611 type sequence R description binding site for residue HCY I 900 source : AC5 49) chain I residue 623 type sequence F description binding site for residue HCY I 900 source : AC5 50) chain I residue 642 type sequence Q description binding site for residue HCY I 900 source : AC5 51) chain I residue 735 type sequence Y description binding site for residue HCY I 900 source : AC5 52) chain I residue 736 type sequence C description binding site for residue HCY I 900 source : AC5 53) chain I residue 739 type sequence T description binding site for residue HCY I 900 source : AC5 54) chain I residue 747 type sequence I description binding site for residue HCY I 900 source : AC5 55) chain K residue 563 type sequence L description binding site for residue HCY K 900 source : AC6 56) chain K residue 564 type sequence N description binding site for residue HCY K 900 source : AC6 57) chain K residue 570 type sequence Q description binding site for residue HCY K 900 source : AC6 58) chain K residue 604 type sequence M description binding site for residue HCY K 900 source : AC6 59) chain K residue 611 type sequence R description binding site for residue HCY K 900 source : AC6 60) chain K residue 623 type sequence F description binding site for residue HCY K 900 source : AC6 61) chain K residue 642 type sequence Q description binding site for residue HCY K 900 source : AC6 62) chain K residue 735 type sequence Y description binding site for residue HCY K 900 source : AC6 63) chain K residue 736 type sequence C description binding site for residue HCY K 900 source : AC6 64) chain K residue 739 type sequence T description binding site for residue HCY K 900 source : AC6 65) chain K residue 747 type sequence I description binding site for residue HCY K 900 source : AC6 66) chain A residue 703 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:12144530 source Swiss-Prot : SWS_FT_FI1 67) chain K residue 703 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:12144530 source Swiss-Prot : SWS_FT_FI1 68) chain C residue 703 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:12144530 source Swiss-Prot : SWS_FT_FI1 69) chain E residue 703 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:12144530 source Swiss-Prot : SWS_FT_FI1 70) chain G residue 703 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:12144530 source Swiss-Prot : SWS_FT_FI1 71) chain I residue 703 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:12144530 source Swiss-Prot : SWS_FT_FI1

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