eF-site ID 4osf-C PDB Code 4osf Chain C click to enlarge Title 4-(2-isothiocyanatoethyl)phenol inhibitor complexed with Macrophage Migration Inhibitory Factor Classification ISOMERASE/ISOMERASE INHIBITOR Compound Macrophage migration inhibitory factor Source Homo sapiens (Human) (MIF_HUMAN) Sequence C:  PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVH VVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLC GLLAERLRISPDRVYINYYDMNAANVGWNNSTFA Description Functional site 1) chain C residue 96 type sequence Y description BINDING SITE FOR RESIDUE 4MT A 201 source : AC1 2) chain C residue 98 type sequence N description BINDING SITE FOR RESIDUE 4MT A 201 source : AC1 3) chain C residue 54 type sequence S description BINDING SITE FOR RESIDUE SO4 A 202 source : AC2 4) chain C residue 63 type sequence H description BINDING SITE FOR RESIDUE SO4 A 203 source : AC3 5) chain C residue 100 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 203 source : AC3 6) chain C residue 16 type sequence P description BINDING SITE FOR RESIDUE SO4 A 205 source : AC5 7) chain C residue 17 type sequence D description BINDING SITE FOR RESIDUE SO4 A 205 source : AC5 8) chain C residue 53 type sequence S description BINDING SITE FOR RESIDUE SO4 A 208 source : AC8 9) chain C residue 54 type sequence S description BINDING SITE FOR RESIDUE SO4 A 208 source : AC8 10) chain C residue 55 type sequence E description BINDING SITE FOR RESIDUE SO4 A 208 source : AC8 11) chain C residue 2 type sequence P description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 12) chain C residue 3 type sequence M description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 13) chain C residue 33 type sequence K description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 14) chain C residue 37 type sequence Y description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 15) chain C residue 63 type sequence H description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 16) chain C residue 65 type sequence I description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 17) chain C residue 102 type sequence M description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 18) chain C residue 107 type sequence V description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 19) chain C residue 17 type sequence D description BINDING SITE FOR RESIDUE SO4 C 202 source : BC5 20) chain C residue 18 type sequence G description BINDING SITE FOR RESIDUE SO4 C 202 source : BC5 21) chain C residue 19 type sequence F description BINDING SITE FOR RESIDUE SO4 C 202 source : BC5 22) chain C residue 20 type sequence L description BINDING SITE FOR RESIDUE SO4 C 202 source : BC5 23) chain C residue 21 type sequence S description BINDING SITE FOR RESIDUE SO4 C 202 source : BC5 24) chain C residue 71 type sequence A description BINDING SITE FOR RESIDUE SO4 C 203 source : BC6 25) chain C residue 74 type sequence R description BINDING SITE FOR RESIDUE SO4 C 203 source : BC6 26) chain C residue 66 type sequence G description BINDING SITE FOR RESIDUE SO4 C 204 source : BC7 27) chain C residue 67 type sequence K description BINDING SITE FOR RESIDUE SO4 C 204 source : BC7 28) chain C residue 69 type sequence G description BINDING SITE FOR RESIDUE SO4 C 205 source : BC8 29) chain C residue 70 type sequence G description BINDING SITE FOR RESIDUE SO4 C 205 source : BC8 30) chain C residue 71 type sequence A description BINDING SITE FOR RESIDUE SO4 C 205 source : BC8 31) chain C residue 72 type sequence Q description BINDING SITE FOR RESIDUE SO4 C 205 source : BC8 32) chain C residue 33 type sequence K description BINDING SITE FOR RESIDUE IPA C 206 source : BC9 33) chain C residue 93 type sequence D description BINDING SITE FOR RESIDUE IPA C 206 source : BC9 34) chain C residue 78 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P34884 source Swiss-Prot : SWS_FT_FI3 35) chain C residue 33 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 36) chain C residue 65 type BINDING sequence I description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 37) chain C residue 98 type BINDING sequence N description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 38) chain C residue 2 type ACT_SITE sequence P description Proton acceptor; via imino nitrogen => ECO:0000250|UniProtKB:P34884 source Swiss-Prot : SWS_FT_FI1

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