eF-site ID 4osf-B PDB Code 4osf Chain B click to enlarge Title 4-(2-isothiocyanatoethyl)phenol inhibitor complexed with Macrophage Migration Inhibitory Factor Classification ISOMERASE/ISOMERASE INHIBITOR Compound Macrophage migration inhibitory factor Source Homo sapiens (Human) (MIF_HUMAN) Sequence B:  PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVH VVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLC GLLAERLRISPDRVYINYYDMNAANVGWNNSTFA Description Functional site 1) chain B residue 63 type sequence H description BINDING SITE FOR RESIDUE SO4 A 203 source : AC3 2) chain B residue 100 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 203 source : AC3 3) chain B residue 2 type sequence P description BINDING SITE FOR RESIDUE 4MT B 201 source : BC1 4) chain B residue 37 type sequence Y description BINDING SITE FOR RESIDUE 4MT B 201 source : BC1 5) chain B residue 63 type sequence H description BINDING SITE FOR RESIDUE 4MT B 201 source : BC1 6) chain B residue 102 type sequence M description BINDING SITE FOR RESIDUE 4MT B 201 source : BC1 7) chain B residue 107 type sequence V description BINDING SITE FOR RESIDUE 4MT B 201 source : BC1 8) chain B residue 69 type sequence G description BINDING SITE FOR RESIDUE SO4 B 202 source : BC2 9) chain B residue 70 type sequence G description BINDING SITE FOR RESIDUE SO4 B 202 source : BC2 10) chain B residue 71 type sequence A description BINDING SITE FOR RESIDUE SO4 B 202 source : BC2 11) chain B residue 72 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 202 source : BC2 12) chain B residue 67 type sequence K description BINDING SITE FOR RESIDUE CL B 203 source : BC3 13) chain B residue 96 type sequence Y description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 14) chain B residue 98 type sequence N description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 15) chain B residue 74 type sequence R description BINDING SITE FOR RESIDUE SO4 C 203 source : BC6 16) chain B residue 78 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P34884 source Swiss-Prot : SWS_FT_FI3 17) chain B residue 33 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 18) chain B residue 65 type BINDING sequence I description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 19) chain B residue 98 type BINDING sequence N description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 20) chain B residue 2 type ACT_SITE sequence P description Proton acceptor; via imino nitrogen => ECO:0000250|UniProtKB:P34884 source Swiss-Prot : SWS_FT_FI1

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