eF-site ID 4osf-ABC PDB Code 4osf Chain A, B, C click to enlarge Title 4-(2-isothiocyanatoethyl)phenol inhibitor complexed with Macrophage Migration Inhibitory Factor Classification ISOMERASE/ISOMERASE INHIBITOR Compound Macrophage migration inhibitory factor Source Homo sapiens (Human) (MIF_HUMAN) Sequence A:  PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVH VVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLC GLLAERLRISPDRVYINYYDMNAANVGWNNSTFA B:  PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVH VVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLC GLLAERLRISPDRVYINYYDMNAANVGWNNSTFA C:  PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVH VVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLC GLLAERLRISPDRVYINYYDMNAANVGWNNSTFA Description Functional site 1) chain A residue 2 type sequence P description BINDING SITE FOR RESIDUE 4MT A 201 source : AC1 2) chain A residue 3 type sequence M description BINDING SITE FOR RESIDUE 4MT A 201 source : AC1 3) chain A residue 37 type sequence Y description BINDING SITE FOR RESIDUE 4MT A 201 source : AC1 4) chain A residue 63 type sequence H description BINDING SITE FOR RESIDUE 4MT A 201 source : AC1 5) chain A residue 65 type sequence I description BINDING SITE FOR RESIDUE 4MT A 201 source : AC1 6) chain A residue 102 type sequence M description BINDING SITE FOR RESIDUE 4MT A 201 source : AC1 7) chain A residue 107 type sequence V description BINDING SITE FOR RESIDUE 4MT A 201 source : AC1 8) chain C residue 96 type sequence Y description BINDING SITE FOR RESIDUE 4MT A 201 source : AC1 9) chain C residue 98 type sequence N description BINDING SITE FOR RESIDUE 4MT A 201 source : AC1 10) chain A residue 16 type sequence P description BINDING SITE FOR RESIDUE SO4 A 202 source : AC2 11) chain A residue 17 type sequence D description BINDING SITE FOR RESIDUE SO4 A 202 source : AC2 12) chain C residue 54 type sequence S description BINDING SITE FOR RESIDUE SO4 A 202 source : AC2 13) chain A residue 63 type sequence H description BINDING SITE FOR RESIDUE SO4 A 203 source : AC3 14) chain A residue 100 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 203 source : AC3 15) chain B residue 63 type sequence H description BINDING SITE FOR RESIDUE SO4 A 203 source : AC3 16) chain B residue 100 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 203 source : AC3 17) chain C residue 63 type sequence H description BINDING SITE FOR RESIDUE SO4 A 203 source : AC3 18) chain C residue 100 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 203 source : AC3 19) chain A residue 37 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 204 source : AC4 20) chain A residue 74 type sequence R description BINDING SITE FOR RESIDUE SO4 A 205 source : AC5 21) chain C residue 16 type sequence P description BINDING SITE FOR RESIDUE SO4 A 205 source : AC5 22) chain C residue 17 type sequence D description BINDING SITE FOR RESIDUE SO4 A 205 source : AC5 23) chain A residue 69 type sequence G description BINDING SITE FOR RESIDUE SO4 A 206 source : AC6 24) chain A residue 70 type sequence G description BINDING SITE FOR RESIDUE SO4 A 206 source : AC6 25) chain A residue 71 type sequence A description BINDING SITE FOR RESIDUE SO4 A 206 source : AC6 26) chain A residue 72 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 206 source : AC6 27) chain A residue 71 type sequence A description BINDING SITE FOR RESIDUE SO4 A 207 source : AC7 28) chain A residue 74 type sequence R description BINDING SITE FOR RESIDUE SO4 A 207 source : AC7 29) chain A residue 16 type sequence P description BINDING SITE FOR RESIDUE SO4 A 208 source : AC8 30) chain C residue 53 type sequence S description BINDING SITE FOR RESIDUE SO4 A 208 source : AC8 31) chain C residue 54 type sequence S description BINDING SITE FOR RESIDUE SO4 A 208 source : AC8 32) chain C residue 55 type sequence E description BINDING SITE FOR RESIDUE SO4 A 208 source : AC8 33) chain A residue 67 type sequence K description BINDING SITE FOR RESIDUE CL A 209 source : AC9 34) chain A residue 96 type sequence Y description BINDING SITE FOR RESIDUE 4MT B 201 source : BC1 35) chain A residue 98 type sequence N description BINDING SITE FOR RESIDUE 4MT B 201 source : BC1 36) chain B residue 2 type sequence P description BINDING SITE FOR RESIDUE 4MT B 201 source : BC1 37) chain B residue 37 type sequence Y description BINDING SITE FOR RESIDUE 4MT B 201 source : BC1 38) chain B residue 63 type sequence H description BINDING SITE FOR RESIDUE 4MT B 201 source : BC1 39) chain B residue 102 type sequence M description BINDING SITE FOR RESIDUE 4MT B 201 source : BC1 40) chain B residue 107 type sequence V description BINDING SITE FOR RESIDUE 4MT B 201 source : BC1 41) chain B residue 69 type sequence G description BINDING SITE FOR RESIDUE SO4 B 202 source : BC2 42) chain B residue 70 type sequence G description BINDING SITE FOR RESIDUE SO4 B 202 source : BC2 43) chain B residue 71 type sequence A description BINDING SITE FOR RESIDUE SO4 B 202 source : BC2 44) chain B residue 72 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 202 source : BC2 45) chain B residue 67 type sequence K description BINDING SITE FOR RESIDUE CL B 203 source : BC3 46) chain B residue 96 type sequence Y description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 47) chain B residue 98 type sequence N description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 48) chain C residue 2 type sequence P description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 49) chain C residue 3 type sequence M description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 50) chain C residue 33 type sequence K description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 51) chain C residue 37 type sequence Y description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 52) chain C residue 63 type sequence H description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 53) chain C residue 65 type sequence I description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 54) chain C residue 102 type sequence M description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 55) chain C residue 107 type sequence V description BINDING SITE FOR RESIDUE 4MT C 201 source : BC4 56) chain A residue 78 type sequence K description BINDING SITE FOR RESIDUE SO4 C 202 source : BC5 57) chain C residue 17 type sequence D description BINDING SITE FOR RESIDUE SO4 C 202 source : BC5 58) chain C residue 18 type sequence G description BINDING SITE FOR RESIDUE SO4 C 202 source : BC5 59) chain C residue 19 type sequence F description BINDING SITE FOR RESIDUE SO4 C 202 source : BC5 60) chain C residue 20 type sequence L description BINDING SITE FOR RESIDUE SO4 C 202 source : BC5 61) chain C residue 21 type sequence S description BINDING SITE FOR RESIDUE SO4 C 202 source : BC5 62) chain B residue 74 type sequence R description BINDING SITE FOR RESIDUE SO4 C 203 source : BC6 63) chain C residue 71 type sequence A description BINDING SITE FOR RESIDUE SO4 C 203 source : BC6 64) chain C residue 74 type sequence R description BINDING SITE FOR RESIDUE SO4 C 203 source : BC6 65) chain C residue 66 type sequence G description BINDING SITE FOR RESIDUE SO4 C 204 source : BC7 66) chain C residue 67 type sequence K description BINDING SITE FOR RESIDUE SO4 C 204 source : BC7 67) chain C residue 69 type sequence G description BINDING SITE FOR RESIDUE SO4 C 205 source : BC8 68) chain C residue 70 type sequence G description BINDING SITE FOR RESIDUE SO4 C 205 source : BC8 69) chain C residue 71 type sequence A description BINDING SITE FOR RESIDUE SO4 C 205 source : BC8 70) chain C residue 72 type sequence Q description BINDING SITE FOR RESIDUE SO4 C 205 source : BC8 71) chain A residue 110 type sequence N description BINDING SITE FOR RESIDUE IPA C 206 source : BC9 72) chain C residue 33 type sequence K description BINDING SITE FOR RESIDUE IPA C 206 source : BC9 73) chain C residue 93 type sequence D description BINDING SITE FOR RESIDUE IPA C 206 source : BC9 74) chain A residue 78 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P34884 source Swiss-Prot : SWS_FT_FI3 75) chain B residue 78 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P34884 source Swiss-Prot : SWS_FT_FI3 76) chain C residue 78 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P34884 source Swiss-Prot : SWS_FT_FI3 77) chain A residue 33 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 78) chain A residue 65 type BINDING sequence I description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 79) chain A residue 98 type BINDING sequence N description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 80) chain B residue 33 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 81) chain B residue 65 type BINDING sequence I description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 82) chain B residue 98 type BINDING sequence N description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 83) chain C residue 33 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 84) chain C residue 65 type BINDING sequence I description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 85) chain C residue 98 type BINDING sequence N description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 86) chain A residue 2 type ACT_SITE sequence P description Proton acceptor; via imino nitrogen => ECO:0000250|UniProtKB:P34884 source Swiss-Prot : SWS_FT_FI1 87) chain B residue 2 type ACT_SITE sequence P description Proton acceptor; via imino nitrogen => ECO:0000250|UniProtKB:P34884 source Swiss-Prot : SWS_FT_FI1 88) chain C residue 2 type ACT_SITE sequence P description Proton acceptor; via imino nitrogen => ECO:0000250|UniProtKB:P34884 source Swiss-Prot : SWS_FT_FI1 89) chain A residue 55-69 type prosite sequence EPCALCSLHSIGKIG description MIF Macrophage migration inhibitory factor family signature. EPCAlcsLhSIGkIG source prosite : PS01158

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