eF-site ID 4osf-A PDB Code 4osf Chain A click to enlarge Title 4-(2-isothiocyanatoethyl)phenol inhibitor complexed with Macrophage Migration Inhibitory Factor Classification ISOMERASE/ISOMERASE INHIBITOR Compound Macrophage migration inhibitory factor Source Homo sapiens (Human) (MIF_HUMAN) Sequence A:  PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVH VVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLC GLLAERLRISPDRVYINYYDMNAANVGWNNSTFA Description Functional site 1) chain A residue 2 type sequence P description BINDING SITE FOR RESIDUE 4MT A 201 source : AC1 2) chain A residue 3 type sequence M description BINDING SITE FOR RESIDUE 4MT A 201 source : AC1 3) chain A residue 37 type sequence Y description BINDING SITE FOR RESIDUE 4MT A 201 source : AC1 4) chain A residue 63 type sequence H description BINDING SITE FOR RESIDUE 4MT A 201 source : AC1 5) chain A residue 65 type sequence I description BINDING SITE FOR RESIDUE 4MT A 201 source : AC1 6) chain A residue 102 type sequence M description BINDING SITE FOR RESIDUE 4MT A 201 source : AC1 7) chain A residue 107 type sequence V description BINDING SITE FOR RESIDUE 4MT A 201 source : AC1 8) chain A residue 16 type sequence P description BINDING SITE FOR RESIDUE SO4 A 202 source : AC2 9) chain A residue 17 type sequence D description BINDING SITE FOR RESIDUE SO4 A 202 source : AC2 10) chain A residue 63 type sequence H description BINDING SITE FOR RESIDUE SO4 A 203 source : AC3 11) chain A residue 100 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 203 source : AC3 12) chain A residue 37 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 204 source : AC4 13) chain A residue 74 type sequence R description BINDING SITE FOR RESIDUE SO4 A 205 source : AC5 14) chain A residue 69 type sequence G description BINDING SITE FOR RESIDUE SO4 A 206 source : AC6 15) chain A residue 70 type sequence G description BINDING SITE FOR RESIDUE SO4 A 206 source : AC6 16) chain A residue 71 type sequence A description BINDING SITE FOR RESIDUE SO4 A 206 source : AC6 17) chain A residue 72 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 206 source : AC6 18) chain A residue 71 type sequence A description BINDING SITE FOR RESIDUE SO4 A 207 source : AC7 19) chain A residue 74 type sequence R description BINDING SITE FOR RESIDUE SO4 A 207 source : AC7 20) chain A residue 16 type sequence P description BINDING SITE FOR RESIDUE SO4 A 208 source : AC8 21) chain A residue 67 type sequence K description BINDING SITE FOR RESIDUE CL A 209 source : AC9 22) chain A residue 96 type sequence Y description BINDING SITE FOR RESIDUE 4MT B 201 source : BC1 23) chain A residue 98 type sequence N description BINDING SITE FOR RESIDUE 4MT B 201 source : BC1 24) chain A residue 78 type sequence K description BINDING SITE FOR RESIDUE SO4 C 202 source : BC5 25) chain A residue 110 type sequence N description BINDING SITE FOR RESIDUE IPA C 206 source : BC9 26) chain A residue 55-69 type prosite sequence EPCALCSLHSIGKIG description MIF Macrophage migration inhibitory factor family signature. EPCAlcsLhSIGkIG source prosite : PS01158 27) chain A residue 2 type ACT_SITE sequence P description Proton acceptor; via imino nitrogen => ECO:0000250|UniProtKB:P34884 source Swiss-Prot : SWS_FT_FI1 28) chain A residue 33 type BINDING sequence K description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 29) chain A residue 65 type BINDING sequence I description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 30) chain A residue 98 type BINDING sequence N description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677 source Swiss-Prot : SWS_FT_FI2 31) chain A residue 78 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P34884 source Swiss-Prot : SWS_FT_FI3

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