eF-site ID 4osf-A
PDB Code 4osf
Chain A

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Title 4-(2-isothiocyanatoethyl)phenol inhibitor complexed with Macrophage Migration Inhibitory Factor
Classification ISOMERASE/ISOMERASE INHIBITOR
Compound Macrophage migration inhibitory factor
Source Homo sapiens (Human) (MIF_HUMAN)
Sequence A:  PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVH
VVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLC
GLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
Description


Functional site

1) chain A
residue 2
type
sequence P
description BINDING SITE FOR RESIDUE 4MT A 201
source : AC1

2) chain A
residue 3
type
sequence M
description BINDING SITE FOR RESIDUE 4MT A 201
source : AC1

3) chain A
residue 37
type
sequence Y
description BINDING SITE FOR RESIDUE 4MT A 201
source : AC1

4) chain A
residue 63
type
sequence H
description BINDING SITE FOR RESIDUE 4MT A 201
source : AC1

5) chain A
residue 65
type
sequence I
description BINDING SITE FOR RESIDUE 4MT A 201
source : AC1

6) chain A
residue 102
type
sequence M
description BINDING SITE FOR RESIDUE 4MT A 201
source : AC1

7) chain A
residue 107
type
sequence V
description BINDING SITE FOR RESIDUE 4MT A 201
source : AC1

8) chain A
residue 16
type
sequence P
description BINDING SITE FOR RESIDUE SO4 A 202
source : AC2

9) chain A
residue 17
type
sequence D
description BINDING SITE FOR RESIDUE SO4 A 202
source : AC2

10) chain A
residue 63
type
sequence H
description BINDING SITE FOR RESIDUE SO4 A 203
source : AC3

11) chain A
residue 100
type
sequence Y
description BINDING SITE FOR RESIDUE SO4 A 203
source : AC3

12) chain A
residue 37
type
sequence Y
description BINDING SITE FOR RESIDUE SO4 A 204
source : AC4

13) chain A
residue 74
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 205
source : AC5

14) chain A
residue 69
type
sequence G
description BINDING SITE FOR RESIDUE SO4 A 206
source : AC6

15) chain A
residue 70
type
sequence G
description BINDING SITE FOR RESIDUE SO4 A 206
source : AC6

16) chain A
residue 71
type
sequence A
description BINDING SITE FOR RESIDUE SO4 A 206
source : AC6

17) chain A
residue 72
type
sequence Q
description BINDING SITE FOR RESIDUE SO4 A 206
source : AC6

18) chain A
residue 71
type
sequence A
description BINDING SITE FOR RESIDUE SO4 A 207
source : AC7

19) chain A
residue 74
type
sequence R
description BINDING SITE FOR RESIDUE SO4 A 207
source : AC7

20) chain A
residue 16
type
sequence P
description BINDING SITE FOR RESIDUE SO4 A 208
source : AC8

21) chain A
residue 67
type
sequence K
description BINDING SITE FOR RESIDUE CL A 209
source : AC9

22) chain A
residue 96
type
sequence Y
description BINDING SITE FOR RESIDUE 4MT B 201
source : BC1

23) chain A
residue 98
type
sequence N
description BINDING SITE FOR RESIDUE 4MT B 201
source : BC1

24) chain A
residue 78
type
sequence K
description BINDING SITE FOR RESIDUE SO4 C 202
source : BC5

25) chain A
residue 110
type
sequence N
description BINDING SITE FOR RESIDUE IPA C 206
source : BC9

26) chain A
residue 55-69
type prosite
sequence EPCALCSLHSIGKIG
description MIF Macrophage migration inhibitory factor family signature. EPCAlcsLhSIGkIG
source prosite : PS01158

27) chain A
residue 2
type ACT_SITE
sequence P
description Proton acceptor; via imino nitrogen => ECO:0000250|UniProtKB:P34884
source Swiss-Prot : SWS_FT_FI1

28) chain A
residue 33
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677
source Swiss-Prot : SWS_FT_FI2

29) chain A
residue 65
type BINDING
sequence I
description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677
source Swiss-Prot : SWS_FT_FI2

30) chain A
residue 98
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:11170644, ECO:0000269|PubMed:17526494, ECO:0000269|PubMed:19090677
source Swiss-Prot : SWS_FT_FI2

31) chain A
residue 78
type MOD_RES
sequence K
description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P34884
source Swiss-Prot : SWS_FT_FI3


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