eF-site ID 4or2-B PDB Code 4or2 Chain B click to enlarge Title Human class C G protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator Classification SIGNALING PROTEIN Compound Soluble cytochrome b562, Metabotropic glutamate receptor 1 Source Homo sapiens (Human) (GRM1_HUMAN) Sequence B:  DLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQ KATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANE GKVKEAQAAAEQLKTTRNAYIQKYLIPVRYLEWSNIESII AIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIIL AGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSAL VTKTNRIARILAGCTRKPRFMSAWAQVIIASILISVQLTL VVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYN GLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLA FVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIA KPERNV Description Functional site 1) chain B residue 588 type sequence W description BINDING SITE FOR RESIDUE CLR A 1902 source : AC2 2) chain B residue 646 type sequence F description BINDING SITE FOR RESIDUE CLR A 1902 source : AC2 3) chain B residue 1056 type sequence P description BINDING SITE FOR RESIDUE CLR A 1903 source : AC3 4) chain B residue 588 type sequence W description BINDING SITE FOR RESIDUE CLR A 1904 source : AC4 5) chain B residue 702 type sequence S description BINDING SITE FOR RESIDUE OLA A 1906 source : AC6 6) chain B residue 648 type sequence L description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 7) chain B residue 660 type sequence Q description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 8) chain B residue 664 type sequence V description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 9) chain B residue 757 type sequence L description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 10) chain B residue 760 type sequence N description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 11) chain B residue 794 type sequence T description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 12) chain B residue 797 type sequence I description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 13) chain B residue 798 type sequence W description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 14) chain B residue 801 type sequence F description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 15) chain B residue 805 type sequence Y description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 16) chain B residue 811 type sequence K description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 17) chain B residue 812 type sequence I description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 18) chain B residue 815 type sequence T description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 19) chain B residue 818 type sequence A description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 20) chain B residue 822 type sequence S description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 21) chain B residue 809 type sequence N description BINDING SITE FOR RESIDUE PO4 B 1902 source : BC1 22) chain B residue 810 type sequence Y description BINDING SITE FOR RESIDUE PO4 B 1902 source : BC1 23) chain B residue 811 type sequence K description BINDING SITE FOR RESIDUE PO4 B 1902 source : BC1 24) chain B residue 812 type sequence I description BINDING SITE FOR RESIDUE PO4 B 1902 source : BC1 25) chain B residue 813 type sequence I description BINDING SITE FOR RESIDUE PO4 B 1902 source : BC1 26) chain B residue 698 type sequence P description BINDING SITE FOR RESIDUE PO4 B 1903 source : BC2 27) chain B residue 702 type sequence S description BINDING SITE FOR RESIDUE PO4 B 1903 source : BC2 28) chain B residue 750 type sequence N description BINDING SITE FOR RESIDUE OLC B 1904 source : BC3 29) chain B residue 588 type sequence W description BINDING SITE FOR RESIDUE CLR B 1905 source : BC4 30) chain B residue 594 type sequence I description BINDING SITE FOR RESIDUE CLR B 1905 source : BC4 31) chain B residue 597 type sequence I description BINDING SITE FOR RESIDUE CLR B 1905 source : BC4 32) chain B residue 598 type sequence A description BINDING SITE FOR RESIDUE CLR B 1905 source : BC4 33) chain B residue 653 type sequence T description BINDING SITE FOR RESIDUE CLR B 1906 source : BC5 34) chain B residue 655 type sequence T description BINDING SITE FOR RESIDUE CLR B 1906 source : BC5 35) chain B residue 593-615 type TRANSMEM sequence SIIAIAFSCLGILVTLFVTLIFV description Helical; Name=1 source Swiss-Prot : SWS_FT_FI2 36) chain B residue 616-629 type TOPO_DOM sequence LYRDTPVVKSSSRE description Cytoplasmic => ECO:0000269|PubMed:24603153 source Swiss-Prot : SWS_FT_FI3 37) chain B residue 681-703 type TOPO_DOM sequence RIARILAGCTRKPRFMSA description Cytoplasmic => ECO:0000269|PubMed:24603153 source Swiss-Prot : SWS_FT_FI3 38) chain B residue 773-785 type TOPO_DOM sequence KTRNVPANFNEAK description Cytoplasmic => ECO:0000269|PubMed:24603153 source Swiss-Prot : SWS_FT_FI3 39) chain B residue 630-650 type TRANSMEM sequence LCYIILAGIFLGYVCPFTLIA description Helical; Name=2 source Swiss-Prot : SWS_FT_FI4 40) chain B residue 651-658 type TOPO_DOM sequence KPTTTSCY description Extracellular => ECO:0000269|PubMed:24603153 source Swiss-Prot : SWS_FT_FI5 41) chain B residue 728-750 type TOPO_DOM sequence EPPMPILSYPSIKEVYLICNTSN description Extracellular => ECO:0000269|PubMed:24603153 source Swiss-Prot : SWS_FT_FI5 42) chain B residue 808-815 type TOPO_DOM sequence SNYKIITT description Extracellular => ECO:0000269|PubMed:24603153 source Swiss-Prot : SWS_FT_FI5 43) chain B residue 659-680 type TRANSMEM sequence LQRLLVGLSSAMCYSALVTKTN description Helical; Name=3 source Swiss-Prot : SWS_FT_FI6 44) chain B residue 704-727 type TRANSMEM sequence WAQVIIASILISVQLTLVVTLIIM description Helical; Name=4 source Swiss-Prot : SWS_FT_FI7 45) chain B residue 751-772 type TRANSMEM sequence LGVVAPLGYNGLLIMSCTYYAF description Helical; Name=5 source Swiss-Prot : SWS_FT_FI8 46) chain B residue 786-807 type TRANSMEM sequence YIAFTMYTTCIIWLAFVPIYFG description Helical; Name=6 source Swiss-Prot : SWS_FT_FI9 47) chain B residue 816-840 type TRANSMEM sequence CFAVSLSVTVALGCMFTPKMYIIIA description Helical; Name=7 source Swiss-Prot : SWS_FT_FI10 48) chain B residue 1007 type BINDING sequence W description axial binding residue source Swiss-Prot : SWS_FT_FI1 49) chain B residue 1102 type BINDING sequence I description axial binding residue source Swiss-Prot : SWS_FT_FI1

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