eF-site ID 4or2-AB PDB Code 4or2 Chain A, B click to enlarge Title Human class C G protein-coupled metabotropic glutamate receptor 1 in complex with a negative allosteric modulator Classification SIGNALING PROTEIN Compound Soluble cytochrome b562, Metabotropic glutamate receptor 1 Source Homo sapiens (Human) (GRM1_HUMAN) Sequence A:  DLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQ KATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANE GKVKEAQAAAEQLKTTRNAYIQKYLIPVRYLEWSNIESII AIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIIL AGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSAL VTKTNRIARILARKPRFMSAWAQVIIASILISVQLTLVVT LIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYNGLL IMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLAFVP IYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIAKPE B:  DLEDNWETLNDNLKVIEKADNAAQVKDALTKMRAAALDAQ KATPPKLEDKSPDSPEMKDFRHGFDILVGQIDDALKLANE GKVKEAQAAAEQLKTTRNAYIQKYLIPVRYLEWSNIESII AIAFSCLGILVTLFVTLIFVLYRDTPVVKSSSRELCYIIL AGIFLGYVCPFTLIAKPTTTSCYLQRLLVGLSSAMCYSAL VTKTNRIARILAGCTRKPRFMSAWAQVIIASILISVQLTL VVTLIIMEPPMPILSYPSIKEVYLICNTSNLGVVAPLGYN GLLIMSCTYYAFKTRNVPANFNEAKYIAFTMYTTCIIWLA FVPIYFGSNYKIITTCFAVSLSVTVALGCMFTPKMYIIIA KPERNV Description Functional site 1) chain A residue 664 type sequence V description BINDING SITE FOR RESIDUE FM9 A 1901 source : AC1 2) chain A residue 668 type sequence S description BINDING SITE FOR RESIDUE FM9 A 1901 source : AC1 3) chain A residue 756 type sequence P description BINDING SITE FOR RESIDUE FM9 A 1901 source : AC1 4) chain A residue 757 type sequence L description BINDING SITE FOR RESIDUE FM9 A 1901 source : AC1 5) chain A residue 760 type sequence N description BINDING SITE FOR RESIDUE FM9 A 1901 source : AC1 6) chain A residue 794 type sequence T description BINDING SITE FOR RESIDUE FM9 A 1901 source : AC1 7) chain A residue 797 type sequence I description BINDING SITE FOR RESIDUE FM9 A 1901 source : AC1 8) chain A residue 798 type sequence W description BINDING SITE FOR RESIDUE FM9 A 1901 source : AC1 9) chain A residue 801 type sequence F description BINDING SITE FOR RESIDUE FM9 A 1901 source : AC1 10) chain A residue 805 type sequence Y description BINDING SITE FOR RESIDUE FM9 A 1901 source : AC1 11) chain A residue 811 type sequence K description BINDING SITE FOR RESIDUE FM9 A 1901 source : AC1 12) chain A residue 815 type sequence T description BINDING SITE FOR RESIDUE FM9 A 1901 source : AC1 13) chain A residue 818 type sequence A description BINDING SITE FOR RESIDUE FM9 A 1901 source : AC1 14) chain A residue 822 type sequence S description BINDING SITE FOR RESIDUE FM9 A 1901 source : AC1 15) chain A residue 597 type sequence I description BINDING SITE FOR RESIDUE CLR A 1902 source : AC2 16) chain A residue 646 type sequence F description BINDING SITE FOR RESIDUE CLR A 1902 source : AC2 17) chain B residue 588 type sequence W description BINDING SITE FOR RESIDUE CLR A 1902 source : AC2 18) chain B residue 646 type sequence F description BINDING SITE FOR RESIDUE CLR A 1902 source : AC2 19) chain A residue 597 type sequence I description BINDING SITE FOR RESIDUE CLR A 1903 source : AC3 20) chain A residue 598 type sequence A description BINDING SITE FOR RESIDUE CLR A 1903 source : AC3 21) chain A residue 602 type sequence L description BINDING SITE FOR RESIDUE CLR A 1903 source : AC3 22) chain B residue 1056 type sequence P description BINDING SITE FOR RESIDUE CLR A 1903 source : AC3 23) chain A residue 588 type sequence W description BINDING SITE FOR RESIDUE CLR A 1904 source : AC4 24) chain A residue 639 type sequence F description BINDING SITE FOR RESIDUE CLR A 1904 source : AC4 25) chain A residue 646 type sequence F description BINDING SITE FOR RESIDUE CLR A 1904 source : AC4 26) chain B residue 588 type sequence W description BINDING SITE FOR RESIDUE CLR A 1904 source : AC4 27) chain A residue 650 type sequence A description BINDING SITE FOR RESIDUE CLR A 1905 source : AC5 28) chain A residue 653 type sequence T description BINDING SITE FOR RESIDUE CLR A 1905 source : AC5 29) chain A residue 810 type sequence Y description BINDING SITE FOR RESIDUE OLA A 1906 source : AC6 30) chain A residue 817 type sequence F description BINDING SITE FOR RESIDUE OLA A 1906 source : AC6 31) chain B residue 702 type sequence S description BINDING SITE FOR RESIDUE OLA A 1906 source : AC6 32) chain A residue 758 type sequence G description BINDING SITE FOR RESIDUE OLC A 1907 source : AC7 33) chain A residue 806 type sequence F description BINDING SITE FOR RESIDUE OLC A 1907 source : AC7 34) chain A residue 589 type sequence S description BINDING SITE FOR RESIDUE OLC A 1908 source : AC8 35) chain A residue 591 type sequence I description BINDING SITE FOR RESIDUE OLC A 1908 source : AC8 36) chain B residue 648 type sequence L description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 37) chain B residue 660 type sequence Q description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 38) chain B residue 664 type sequence V description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 39) chain B residue 757 type sequence L description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 40) chain B residue 760 type sequence N description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 41) chain B residue 794 type sequence T description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 42) chain B residue 797 type sequence I description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 43) chain B residue 798 type sequence W description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 44) chain B residue 801 type sequence F description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 45) chain B residue 805 type sequence Y description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 46) chain B residue 811 type sequence K description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 47) chain B residue 812 type sequence I description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 48) chain B residue 815 type sequence T description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 49) chain B residue 818 type sequence A description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 50) chain B residue 822 type sequence S description BINDING SITE FOR RESIDUE FM9 B 1901 source : AC9 51) chain B residue 809 type sequence N description BINDING SITE FOR RESIDUE PO4 B 1902 source : BC1 52) chain B residue 810 type sequence Y description BINDING SITE FOR RESIDUE PO4 B 1902 source : BC1 53) chain B residue 811 type sequence K description BINDING SITE FOR RESIDUE PO4 B 1902 source : BC1 54) chain B residue 812 type sequence I description BINDING SITE FOR RESIDUE PO4 B 1902 source : BC1 55) chain B residue 813 type sequence I description BINDING SITE FOR RESIDUE PO4 B 1902 source : BC1 56) chain A residue 810 type sequence Y description BINDING SITE FOR RESIDUE PO4 B 1903 source : BC2 57) chain B residue 698 type sequence P description BINDING SITE FOR RESIDUE PO4 B 1903 source : BC2 58) chain B residue 702 type sequence S description BINDING SITE FOR RESIDUE PO4 B 1903 source : BC2 59) chain A residue 836 type sequence Y description BINDING SITE FOR RESIDUE OLC B 1904 source : BC3 60) chain B residue 750 type sequence N description BINDING SITE FOR RESIDUE OLC B 1904 source : BC3 61) chain B residue 588 type sequence W description BINDING SITE FOR RESIDUE CLR B 1905 source : BC4 62) chain B residue 594 type sequence I description BINDING SITE FOR RESIDUE CLR B 1905 source : BC4 63) chain B residue 597 type sequence I description BINDING SITE FOR RESIDUE CLR B 1905 source : BC4 64) chain B residue 598 type sequence A description BINDING SITE FOR RESIDUE CLR B 1905 source : BC4 65) chain B residue 653 type sequence T description BINDING SITE FOR RESIDUE CLR B 1906 source : BC5 66) chain B residue 655 type sequence T description BINDING SITE FOR RESIDUE CLR B 1906 source : BC5 67) chain A residue 593-615 type TRANSMEM sequence SIIAIAFSCLGILVTLFVTLIFV description Helical; Name=1 source Swiss-Prot : SWS_FT_FI2 68) chain B residue 593-615 type TRANSMEM sequence SIIAIAFSCLGILVTLFVTLIFV description Helical; Name=1 source Swiss-Prot : SWS_FT_FI2 69) chain A residue 616-629 type TOPO_DOM sequence LYRDTPVVKSSSRE description Cytoplasmic => ECO:0000269|PubMed:24603153 source Swiss-Prot : SWS_FT_FI3 70) chain A residue 681-703 type TOPO_DOM sequence RIARILARKPRFMSA description Cytoplasmic => ECO:0000269|PubMed:24603153 source Swiss-Prot : SWS_FT_FI3 71) chain A residue 773-785 type TOPO_DOM sequence KTRNVPANFNEAK description Cytoplasmic => ECO:0000269|PubMed:24603153 source Swiss-Prot : SWS_FT_FI3 72) chain B residue 616-629 type TOPO_DOM sequence LYRDTPVVKSSSRE description Cytoplasmic => ECO:0000269|PubMed:24603153 source Swiss-Prot : SWS_FT_FI3 73) chain B residue 681-703 type TOPO_DOM sequence RIARILAGCTRKPRFMSA description Cytoplasmic => ECO:0000269|PubMed:24603153 source Swiss-Prot : SWS_FT_FI3 74) chain B residue 773-785 type TOPO_DOM sequence KTRNVPANFNEAK description Cytoplasmic => ECO:0000269|PubMed:24603153 source Swiss-Prot : SWS_FT_FI3 75) chain A residue 630-650 type TRANSMEM sequence LCYIILAGIFLGYVCPFTLIA description Helical; Name=2 source Swiss-Prot : SWS_FT_FI4 76) chain B residue 630-650 type TRANSMEM sequence LCYIILAGIFLGYVCPFTLIA description Helical; Name=2 source Swiss-Prot : SWS_FT_FI4 77) chain A residue 651-658 type TOPO_DOM sequence KPTTTSCY description Extracellular => ECO:0000269|PubMed:24603153 source Swiss-Prot : SWS_FT_FI5 78) chain A residue 728-750 type TOPO_DOM sequence EPPMPILSYPSIKEVYLICNTSN description Extracellular => ECO:0000269|PubMed:24603153 source Swiss-Prot : SWS_FT_FI5 79) chain A residue 808-815 type TOPO_DOM sequence SNYKIITT description Extracellular => ECO:0000269|PubMed:24603153 source Swiss-Prot : SWS_FT_FI5 80) chain B residue 651-658 type TOPO_DOM sequence KPTTTSCY description Extracellular => ECO:0000269|PubMed:24603153 source Swiss-Prot : SWS_FT_FI5 81) chain B residue 728-750 type TOPO_DOM sequence EPPMPILSYPSIKEVYLICNTSN description Extracellular => ECO:0000269|PubMed:24603153 source Swiss-Prot : SWS_FT_FI5 82) chain B residue 808-815 type TOPO_DOM sequence SNYKIITT description Extracellular => ECO:0000269|PubMed:24603153 source Swiss-Prot : SWS_FT_FI5 83) chain A residue 659-680 type TRANSMEM sequence LQRLLVGLSSAMCYSALVTKTN description Helical; Name=3 source Swiss-Prot : SWS_FT_FI6 84) chain B residue 659-680 type TRANSMEM sequence LQRLLVGLSSAMCYSALVTKTN description Helical; Name=3 source Swiss-Prot : SWS_FT_FI6 85) chain A residue 704-727 type TRANSMEM sequence WAQVIIASILISVQLTLVVTLIIM description Helical; Name=4 source Swiss-Prot : SWS_FT_FI7 86) chain B residue 704-727 type TRANSMEM sequence WAQVIIASILISVQLTLVVTLIIM description Helical; Name=4 source Swiss-Prot : SWS_FT_FI7 87) chain A residue 751-772 type TRANSMEM sequence LGVVAPLGYNGLLIMSCTYYAF description Helical; Name=5 source Swiss-Prot : SWS_FT_FI8 88) chain B residue 751-772 type TRANSMEM sequence LGVVAPLGYNGLLIMSCTYYAF description Helical; Name=5 source Swiss-Prot : SWS_FT_FI8 89) chain A residue 786-807 type TRANSMEM sequence YIAFTMYTTCIIWLAFVPIYFG description Helical; Name=6 source Swiss-Prot : SWS_FT_FI9 90) chain B residue 786-807 type TRANSMEM sequence YIAFTMYTTCIIWLAFVPIYFG description Helical; Name=6 source Swiss-Prot : SWS_FT_FI9 91) chain A residue 816-840 type TRANSMEM sequence CFAVSLSVTVALGCMFTPKMYIIIA description Helical; Name=7 source Swiss-Prot : SWS_FT_FI10 92) chain B residue 816-840 type TRANSMEM sequence CFAVSLSVTVALGCMFTPKMYIIIA description Helical; Name=7 source Swiss-Prot : SWS_FT_FI10 93) chain A residue 781-791 type prosite sequence FNEAKYIAFTM description G_PROTEIN_RECEP_F3_3 G-protein coupled receptors family 3 signature 3. FNEAKyIAFTM source prosite : PS00981 94) chain A residue 1007 type BINDING sequence W description axial binding residue source Swiss-Prot : SWS_FT_FI1 95) chain A residue 1102 type BINDING sequence I description axial binding residue source Swiss-Prot : SWS_FT_FI1 96) chain B residue 1007 type BINDING sequence W description axial binding residue source Swiss-Prot : SWS_FT_FI1 97) chain B residue 1102 type BINDING sequence I description axial binding residue source Swiss-Prot : SWS_FT_FI1

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