eF-site ID 4oqd-ABCD PDB Code 4oqd Chain A, B, C, D click to enlarge Title Crystal structure of the tylM1 N,N-dimethyltransferase in complex with SAH and TDP-Qui3NMe2 Classification TRANSFERASE Compound dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose N,N-dimethyltransferase Source Streptomyces fradiae (Streptomyces roseoflavus) (TYLM1_STRFR) Sequence A:  ADYSGEIAELYDLVHQGKGKDYHREAADLAALVRRHSPKA ASLLDVACGTGMHLRHLADSFGTVEGLELSADMLAIARRR NPDAVLHHGDMRDFSLGRRFSAVTCMFSSIGHLAGQAELD AALERFAAHVLPDGVVVVEPWWFPENFTPGYVAAGTVEAG GTTVTRVSHSSREGEATRIEVHYLVAGPDRGITHHEESHR ITLFTREQYERAFTAAGLSVEFMPGGPSGRGLFTGLPGA B:  PQADYSGEIAELYDLVHQGKGKDYHREAADLAALVRRHSP KAASLLDVACGTGMHLRHLADSFGTVEGLELSADMLAIAR RRNPDAVLHHGDMRDFSLGRRFSAVTCMFSSIGHLAGQAE LDAALERFAAHVLPDGVVVVEPWWFPENFTPGYVAAGTVE AGGTTVTRVSHSSREGEATRIEVHYLVAGPDRGITHHEES HRITLFTREQYERAFTAAGLSVEFMPGGPSGRGLFTGLPG C:  GPQADYSGEIAELYDLVHQGKGKDYHREAADLAALVRRHS PKAASLLDVACGTGMHLRHLADSFGTVEGLELSADMLAIA RRRNPDAVLHHGDMRDFSLGRRFSAVTCMFSSIGHLAGQA ELDAALERFAAHVLPDGVVVVEPWWFPENFTPGYVAAGTV EAGGTTVTRVSHSSREGEATRIEVHYLVAGPDRGITHHEE SHRITLFTREQYERAFTAAGLSVEFMPGGPSGRGLFTGLP G D:  PQADYSGEIAELYDLVHQGKGKDYHREAADLAALVRRHSP KAASLLDVACGTGMHLRHLADSFGTVEGLELSADMLAIAR RRNPDAVLHHGDMRDFSLGRRFSAVTCMFSSIGHLAGQAE LDAALERFAAHVLPDGVVVVEPWWFPENFTPGYVAAGTVE AGGTTVTRVSHSSREGEATRIEVHYLVAGPDRGITHHEES HRITLFTREQYERAFTAAGLSVEFMPGGPSGRGLFTGLPG Description Functional site 1) chain A residue 14 type sequence Y description BINDING SITE FOR RESIDUE SAH A 300 source : AC1 2) chain A residue 22 type sequence Y description BINDING SITE FOR RESIDUE SAH A 300 source : AC1 3) chain A residue 33 type sequence Y description BINDING SITE FOR RESIDUE SAH A 300 source : AC1 4) chain A residue 58 type sequence A description BINDING SITE FOR RESIDUE SAH A 300 source : AC1 5) chain A residue 60 type sequence G description BINDING SITE FOR RESIDUE SAH A 300 source : AC1 6) chain A residue 64 type sequence H description BINDING SITE FOR RESIDUE SAH A 300 source : AC1 7) chain A residue 79 type sequence E description BINDING SITE FOR RESIDUE SAH A 300 source : AC1 8) chain A residue 80 type sequence L description BINDING SITE FOR RESIDUE SAH A 300 source : AC1 9) chain A residue 81 type sequence S description BINDING SITE FOR RESIDUE SAH A 300 source : AC1 10) chain A residue 84 type sequence M description BINDING SITE FOR RESIDUE SAH A 300 source : AC1 11) chain A residue 100 type sequence G description BINDING SITE FOR RESIDUE SAH A 300 source : AC1 12) chain A residue 101 type sequence D description BINDING SITE FOR RESIDUE SAH A 300 source : AC1 13) chain A residue 102 type sequence M description BINDING SITE FOR RESIDUE SAH A 300 source : AC1 14) chain A residue 117 type sequence M description BINDING SITE FOR RESIDUE SAH A 300 source : AC1 15) chain A residue 118 type sequence F description BINDING SITE FOR RESIDUE SAH A 300 source : AC1 16) chain A residue 120 type sequence S description BINDING SITE FOR RESIDUE SAH A 300 source : AC1 17) chain A residue 123 type sequence H description BINDING SITE FOR RESIDUE SAH A 300 source : AC1 18) chain A residue 14 type sequence Y description BINDING SITE FOR RESIDUE QDM A 301 source : AC2 19) chain A residue 26 type sequence H description BINDING SITE FOR RESIDUE QDM A 301 source : AC2 20) chain A residue 29 type sequence K description BINDING SITE FOR RESIDUE QDM A 301 source : AC2 21) chain A residue 118 type sequence F description BINDING SITE FOR RESIDUE QDM A 301 source : AC2 22) chain A residue 152 type sequence W description BINDING SITE FOR RESIDUE QDM A 301 source : AC2 23) chain A residue 153 type sequence W description BINDING SITE FOR RESIDUE QDM A 301 source : AC2 24) chain A residue 157 type sequence N description BINDING SITE FOR RESIDUE QDM A 301 source : AC2 25) chain A residue 158 type sequence F description BINDING SITE FOR RESIDUE QDM A 301 source : AC2 26) chain A residue 159 type sequence T description BINDING SITE FOR RESIDUE QDM A 301 source : AC2 27) chain A residue 162 type sequence Y description BINDING SITE FOR RESIDUE QDM A 301 source : AC2 28) chain A residue 177 type sequence R description BINDING SITE FOR RESIDUE QDM A 301 source : AC2 29) chain A residue 179 type sequence S description BINDING SITE FOR RESIDUE QDM A 301 source : AC2 30) chain A residue 181 type sequence S description BINDING SITE FOR RESIDUE QDM A 301 source : AC2 31) chain A residue 190 type sequence I description BINDING SITE FOR RESIDUE QDM A 301 source : AC2 32) chain A residue 241 type sequence R description BINDING SITE FOR RESIDUE QDM A 301 source : AC2 33) chain B residue 14 type sequence Y description BINDING SITE FOR RESIDUE SAH B 300 source : AC3 34) chain B residue 22 type sequence Y description BINDING SITE FOR RESIDUE SAH B 300 source : AC3 35) chain B residue 33 type sequence Y description BINDING SITE FOR RESIDUE SAH B 300 source : AC3 36) chain B residue 58 type sequence A description BINDING SITE FOR RESIDUE SAH B 300 source : AC3 37) chain B residue 59 type sequence C description BINDING SITE FOR RESIDUE SAH B 300 source : AC3 38) chain B residue 60 type sequence G description BINDING SITE FOR RESIDUE SAH B 300 source : AC3 39) chain B residue 64 type sequence H description BINDING SITE FOR RESIDUE SAH B 300 source : AC3 40) chain B residue 79 type sequence E description BINDING SITE FOR RESIDUE SAH B 300 source : AC3 41) chain B residue 80 type sequence L description BINDING SITE FOR RESIDUE SAH B 300 source : AC3 42) chain B residue 81 type sequence S description BINDING SITE FOR RESIDUE SAH B 300 source : AC3 43) chain B residue 100 type sequence G description BINDING SITE FOR RESIDUE SAH B 300 source : AC3 44) chain B residue 101 type sequence D description BINDING SITE FOR RESIDUE SAH B 300 source : AC3 45) chain B residue 102 type sequence M description BINDING SITE FOR RESIDUE SAH B 300 source : AC3 46) chain B residue 117 type sequence M description BINDING SITE FOR RESIDUE SAH B 300 source : AC3 47) chain B residue 118 type sequence F description BINDING SITE FOR RESIDUE SAH B 300 source : AC3 48) chain B residue 120 type sequence S description BINDING SITE FOR RESIDUE SAH B 300 source : AC3 49) chain B residue 14 type sequence Y description BINDING SITE FOR RESIDUE QDM B 301 source : AC4 50) chain B residue 26 type sequence H description BINDING SITE FOR RESIDUE QDM B 301 source : AC4 51) chain B residue 29 type sequence K description BINDING SITE FOR RESIDUE QDM B 301 source : AC4 52) chain B residue 118 type sequence F description BINDING SITE FOR RESIDUE QDM B 301 source : AC4 53) chain B residue 152 type sequence W description BINDING SITE FOR RESIDUE QDM B 301 source : AC4 54) chain B residue 153 type sequence W description BINDING SITE FOR RESIDUE QDM B 301 source : AC4 55) chain B residue 157 type sequence N description BINDING SITE FOR RESIDUE QDM B 301 source : AC4 56) chain B residue 158 type sequence F description BINDING SITE FOR RESIDUE QDM B 301 source : AC4 57) chain B residue 159 type sequence T description BINDING SITE FOR RESIDUE QDM B 301 source : AC4 58) chain B residue 162 type sequence Y description BINDING SITE FOR RESIDUE QDM B 301 source : AC4 59) chain B residue 177 type sequence R description BINDING SITE FOR RESIDUE QDM B 301 source : AC4 60) chain B residue 179 type sequence S description BINDING SITE FOR RESIDUE QDM B 301 source : AC4 61) chain B residue 181 type sequence S description BINDING SITE FOR RESIDUE QDM B 301 source : AC4 62) chain B residue 190 type sequence I description BINDING SITE FOR RESIDUE QDM B 301 source : AC4 63) chain B residue 210 type sequence H description BINDING SITE FOR RESIDUE QDM B 301 source : AC4 64) chain B residue 241 type sequence R description BINDING SITE FOR RESIDUE QDM B 301 source : AC4 65) chain C residue 14 type sequence Y description BINDING SITE FOR RESIDUE SAH C 300 source : AC5 66) chain C residue 22 type sequence Y description BINDING SITE FOR RESIDUE SAH C 300 source : AC5 67) chain C residue 33 type sequence Y description BINDING SITE FOR RESIDUE SAH C 300 source : AC5 68) chain C residue 58 type sequence A description BINDING SITE FOR RESIDUE SAH C 300 source : AC5 69) chain C residue 60 type sequence G description BINDING SITE FOR RESIDUE SAH C 300 source : AC5 70) chain C residue 64 type sequence H description BINDING SITE FOR RESIDUE SAH C 300 source : AC5 71) chain C residue 79 type sequence E description BINDING SITE FOR RESIDUE SAH C 300 source : AC5 72) chain C residue 80 type sequence L description BINDING SITE FOR RESIDUE SAH C 300 source : AC5 73) chain C residue 81 type sequence S description BINDING SITE FOR RESIDUE SAH C 300 source : AC5 74) chain C residue 84 type sequence M description BINDING SITE FOR RESIDUE SAH C 300 source : AC5 75) chain C residue 100 type sequence G description BINDING SITE FOR RESIDUE SAH C 300 source : AC5 76) chain C residue 101 type sequence D description BINDING SITE FOR RESIDUE SAH C 300 source : AC5 77) chain C residue 102 type sequence M description BINDING SITE FOR RESIDUE SAH C 300 source : AC5 78) chain C residue 103 type sequence R description BINDING SITE FOR RESIDUE SAH C 300 source : AC5 79) chain C residue 117 type sequence M description BINDING SITE FOR RESIDUE SAH C 300 source : AC5 80) chain C residue 118 type sequence F description BINDING SITE FOR RESIDUE SAH C 300 source : AC5 81) chain C residue 120 type sequence S description BINDING SITE FOR RESIDUE SAH C 300 source : AC5 82) chain C residue 14 type sequence Y description BINDING SITE FOR RESIDUE QDM C 301 source : AC6 83) chain C residue 26 type sequence H description BINDING SITE FOR RESIDUE QDM C 301 source : AC6 84) chain C residue 29 type sequence K description BINDING SITE FOR RESIDUE QDM C 301 source : AC6 85) chain C residue 118 type sequence F description BINDING SITE FOR RESIDUE QDM C 301 source : AC6 86) chain C residue 119 type sequence S description BINDING SITE FOR RESIDUE QDM C 301 source : AC6 87) chain C residue 152 type sequence W description BINDING SITE FOR RESIDUE QDM C 301 source : AC6 88) chain C residue 153 type sequence W description BINDING SITE FOR RESIDUE QDM C 301 source : AC6 89) chain C residue 157 type sequence N description BINDING SITE FOR RESIDUE QDM C 301 source : AC6 90) chain C residue 158 type sequence F description BINDING SITE FOR RESIDUE QDM C 301 source : AC6 91) chain C residue 159 type sequence T description BINDING SITE FOR RESIDUE QDM C 301 source : AC6 92) chain C residue 162 type sequence Y description BINDING SITE FOR RESIDUE QDM C 301 source : AC6 93) chain C residue 177 type sequence R description BINDING SITE FOR RESIDUE QDM C 301 source : AC6 94) chain C residue 179 type sequence S description BINDING SITE FOR RESIDUE QDM C 301 source : AC6 95) chain C residue 181 type sequence S description BINDING SITE FOR RESIDUE QDM C 301 source : AC6 96) chain C residue 190 type sequence I description BINDING SITE FOR RESIDUE QDM C 301 source : AC6 97) chain C residue 210 type sequence H description BINDING SITE FOR RESIDUE QDM C 301 source : AC6 98) chain C residue 241 type sequence R description BINDING SITE FOR RESIDUE QDM C 301 source : AC6 99) chain D residue 14 type sequence Y description BINDING SITE FOR RESIDUE SAH D 300 source : AC7 100) chain D residue 22 type sequence Y description BINDING SITE FOR RESIDUE SAH D 300 source : AC7 101) chain D residue 33 type sequence Y description BINDING SITE FOR RESIDUE SAH D 300 source : AC7 102) chain D residue 58 type sequence A description BINDING SITE FOR RESIDUE SAH D 300 source : AC7 103) chain D residue 59 type sequence C description BINDING SITE FOR RESIDUE SAH D 300 source : AC7 104) chain D residue 60 type sequence G description BINDING SITE FOR RESIDUE SAH D 300 source : AC7 105) chain D residue 64 type sequence H description BINDING SITE FOR RESIDUE SAH D 300 source : AC7 106) chain D residue 79 type sequence E description BINDING SITE FOR RESIDUE SAH D 300 source : AC7 107) chain D residue 80 type sequence L description BINDING SITE FOR RESIDUE SAH D 300 source : AC7 108) chain D residue 81 type sequence S description BINDING SITE FOR RESIDUE SAH D 300 source : AC7 109) chain D residue 84 type sequence M description BINDING SITE FOR RESIDUE SAH D 300 source : AC7 110) chain D residue 100 type sequence G description BINDING SITE FOR RESIDUE SAH D 300 source : AC7 111) chain D residue 101 type sequence D description BINDING SITE FOR RESIDUE SAH D 300 source : AC7 112) chain D residue 102 type sequence M description BINDING SITE FOR RESIDUE SAH D 300 source : AC7 113) chain D residue 117 type sequence M description BINDING SITE FOR RESIDUE SAH D 300 source : AC7 114) chain D residue 118 type sequence F description BINDING SITE FOR RESIDUE SAH D 300 source : AC7 115) chain D residue 120 type sequence S description BINDING SITE FOR RESIDUE SAH D 300 source : AC7 116) chain D residue 123 type sequence H description BINDING SITE FOR RESIDUE SAH D 300 source : AC7 117) chain D residue 14 type sequence Y description BINDING SITE FOR RESIDUE QDM D 301 source : AC8 118) chain D residue 26 type sequence H description BINDING SITE FOR RESIDUE QDM D 301 source : AC8 119) chain D residue 29 type sequence K description BINDING SITE FOR RESIDUE QDM D 301 source : AC8 120) chain D residue 118 type sequence F description BINDING SITE FOR RESIDUE QDM D 301 source : AC8 121) chain D residue 152 type sequence W description BINDING SITE FOR RESIDUE QDM D 301 source : AC8 122) chain D residue 153 type sequence W description BINDING SITE FOR RESIDUE QDM D 301 source : AC8 123) chain D residue 157 type sequence N description BINDING SITE FOR RESIDUE QDM D 301 source : AC8 124) chain D residue 158 type sequence F description BINDING SITE FOR RESIDUE QDM D 301 source : AC8 125) chain D residue 159 type sequence T description BINDING SITE FOR RESIDUE QDM D 301 source : AC8 126) chain D residue 162 type sequence Y description BINDING SITE FOR RESIDUE QDM D 301 source : AC8 127) chain D residue 177 type sequence R description BINDING SITE FOR RESIDUE QDM D 301 source : AC8 128) chain D residue 179 type sequence S description BINDING SITE FOR RESIDUE QDM D 301 source : AC8 129) chain D residue 181 type sequence S description BINDING SITE FOR RESIDUE QDM D 301 source : AC8 130) chain D residue 190 type sequence I description BINDING SITE FOR RESIDUE QDM D 301 source : AC8 131) chain D residue 210 type sequence H description BINDING SITE FOR RESIDUE QDM D 301 source : AC8 132) chain D residue 241 type sequence R description BINDING SITE FOR RESIDUE QDM D 301 source : AC8 133) chain A residue 14 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 134) chain B residue 58 type BINDING sequence A description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 135) chain B residue 79 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 136) chain B residue 117 type BINDING sequence M description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 137) chain C residue 14 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 138) chain C residue 22 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 139) chain C residue 33 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 140) chain C residue 58 type BINDING sequence A description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 141) chain C residue 79 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 142) chain C residue 117 type BINDING sequence M description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 143) chain D residue 14 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 144) chain A residue 22 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 145) chain D residue 22 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 146) chain D residue 33 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 147) chain D residue 58 type BINDING sequence A description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 148) chain D residue 79 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 149) chain D residue 117 type BINDING sequence M description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 150) chain A residue 33 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 151) chain A residue 58 type BINDING sequence A description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 152) chain A residue 79 type BINDING sequence E description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 153) chain A residue 117 type BINDING sequence M description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 154) chain B residue 14 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 155) chain B residue 22 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 156) chain B residue 33 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:21142177 source Swiss-Prot : SWS_FT_FI1 157) chain A residue 101 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 158) chain B residue 101 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 159) chain C residue 101 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2 160) chain D residue 101 type BINDING sequence D description source Swiss-Prot : SWS_FT_FI2

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