eF-site ID 4opx-F PDB Code 4opx Chain F click to enlarge Title Structure of Human PARP-1 bound to a DNA double strand break in complex with (2R)-5-fluoro-2-methyl-2,3-dihydro-1-benzofuran-7-carboxamide Classification TRANSFERASE/DNA/TRANSFERASE INHIBITOR Compound Poly [ADP-ribose] polymerase 1 Source Homo sapiens (Human) (4OPX) Sequence F:  AAVDPDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYY KLQLLWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLY EEKTGNAWHSKNFTKYPKKFYPLEIDKSKLPKPVQDLIKM IFDVESMKKAMVEYEIDLQKMPLGKLSKRQIQAAYSILSE VQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPPLLNNA DSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYE KLKTDIKVVDRDSEEAEIIRKYVKNTHATTHNAYDLEVID IFKIEREGECQRYKPFKQLHNRRLLWHGSRTTNFAGILSQ GLRIAPPEAPVTGYMFGKGIYFADMVSKSANYCHTSQGDP IGLILLGEVALGNMYELKHASHISKLPKGKHSVKGLGKTT PDPSANISLDGVDVPLGTGISSGVNDTSLLYNEYIVYDIA QVNLKYLLKLKFNFKT Description Functional site 1) chain F residue 988 type ACT_SITE sequence E description For poly [ADP-ribose] polymerase activity => ECO:0000305|PubMed:32028527, ECO:0000305|PubMed:7852410, ECO:0000305|PubMed:9315851 source Swiss-Prot : SWS_FT_FI1 2) chain F residue 748 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI11 3) chain F residue 862 type BINDING sequence H description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 4) chain F residue 871 type BINDING sequence G description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 5) chain F residue 878 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 6) chain F residue 904 type BINDING sequence S description BINDING => ECO:0000250|UniProtKB:Q9UGN5 source Swiss-Prot : SWS_FT_FI2 7) chain F residue 594 type MOD_RES sequence T description Phosphothreonine; by PRKDC => ECO:0000269|PubMed:35460603 source Swiss-Prot : SWS_FT_FI6 8) chain F residue 600 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI7 9) chain F residue 621 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI7 10) chain F residue 782 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI8 11) chain F residue 786 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI9

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