eF-site ID 4opx-D PDB Code 4opx Chain D click to enlarge Title Structure of Human PARP-1 bound to a DNA double strand break in complex with (2R)-5-fluoro-2-methyl-2,3-dihydro-1-benzofuran-7-carboxamide Classification TRANSFERASE/DNA/TRANSFERASE INHIBITOR Compound Poly [ADP-ribose] polymerase 1 Source Homo sapiens (Human) (4OPX) Sequence D:  DKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFD GKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKV KKTAEASKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCS TNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEE CSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPK EFREISYLKKLKVKKQDRIFPP Description Functional site 1) chain D residue 21 type sequence C description BINDING SITE FOR RESIDUE ZN D 401 source : AC4 2) chain D residue 24 type sequence C description BINDING SITE FOR RESIDUE ZN D 401 source : AC4 3) chain D residue 53 type sequence H description BINDING SITE FOR RESIDUE ZN D 401 source : AC4 4) chain D residue 56 type sequence C description BINDING SITE FOR RESIDUE ZN D 401 source : AC4 5) chain D residue 295 type sequence C description BINDING SITE FOR RESIDUE ZN D 402 source : AC5 6) chain D residue 298 type sequence C description BINDING SITE FOR RESIDUE ZN D 402 source : AC5 7) chain D residue 311 type sequence C description BINDING SITE FOR RESIDUE ZN D 402 source : AC5 8) chain D residue 321 type sequence C description BINDING SITE FOR RESIDUE ZN D 402 source : AC5 9) chain D residue 295 type MOD_RES sequence C description ADP-ribosylserine => ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:34210965, ECO:0000269|PubMed:34625544 source Swiss-Prot : SWS_FT_FI3 10) chain D residue 298 type MOD_RES sequence C description ADP-ribosylserine => ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:34210965, ECO:0000269|PubMed:34625544 source Swiss-Prot : SWS_FT_FI3 11) chain D residue 311 type MOD_RES sequence C description ADP-ribosylserine => ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:34210965, ECO:0000269|PubMed:34625544 source Swiss-Prot : SWS_FT_FI3 12) chain D residue 321 type MOD_RES sequence C description ADP-ribosylserine => ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:34210965, ECO:0000269|PubMed:34625544 source Swiss-Prot : SWS_FT_FI3 13) chain D residue 274 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI8 14) chain D residue 277 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI8 15) chain D residue 249 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI10

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