eF-site ID 4opx-A PDB Code 4opx Chain A click to enlarge Title Structure of Human PARP-1 bound to a DNA double strand break in complex with (2R)-5-fluoro-2-methyl-2,3-dihydro-1-benzofuran-7-carboxamide Classification TRANSFERASE/DNA/TRANSFERASE INHIBITOR Compound Poly [ADP-ribose] polymerase 1 Source Homo sapiens (Human) (4OPX) Sequence A:  DKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFD GKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKV KKTAEASKKEKDKDSKLEKALKAQNDLIWNIKDELKKVCS TNDLKELLIFNKQQVPSGESAILDRVADGMVFGALLPCEE CSGQLVFKSDAYYCTGDVTAWTKCMVKTQTPNRKEWVTPK EFREISYLKKLKVKKQDRIFPP Description Functional site 1) chain A residue 21 type sequence C description BINDING SITE FOR RESIDUE ZN A 401 source : AC1 2) chain A residue 24 type sequence C description BINDING SITE FOR RESIDUE ZN A 401 source : AC1 3) chain A residue 53 type sequence H description BINDING SITE FOR RESIDUE ZN A 401 source : AC1 4) chain A residue 56 type sequence C description BINDING SITE FOR RESIDUE ZN A 401 source : AC1 5) chain A residue 295 type sequence C description BINDING SITE FOR RESIDUE ZN A 402 source : AC2 6) chain A residue 298 type sequence C description BINDING SITE FOR RESIDUE ZN A 402 source : AC2 7) chain A residue 311 type sequence C description BINDING SITE FOR RESIDUE ZN A 402 source : AC2 8) chain A residue 321 type sequence C description BINDING SITE FOR RESIDUE ZN A 402 source : AC2 9) chain A residue 21-56 type prosite sequence CKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSC description ZF_PARP_1 Zinc finger poly(ADP-ribose) polymerase (PARP)-type signature. CKkCsesIpKdslRmaimvqspmfdgkvph..WYHfsC source prosite : PS00347 10) chain A residue 311 type MOD_RES sequence C description ADP-ribosylserine => ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:34210965, ECO:0000269|PubMed:34625544 source Swiss-Prot : SWS_FT_FI3 11) chain A residue 321 type MOD_RES sequence C description ADP-ribosylserine => ECO:0000269|PubMed:28190768, ECO:0000269|PubMed:29954836, ECO:0000269|PubMed:34210965, ECO:0000269|PubMed:34625544 source Swiss-Prot : SWS_FT_FI3

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