eF-site ID 4ong-HLP PDB Code 4ong Chain H, L, P click to enlarge Title Fab fragment of 3D6 in complex with amyloid beta 1-40 Classification IMMUNE SYSTEM Compound 3D6 FAB ANTIBODY HEAVY CHAIN Source Homo sapiens (Human) (4ONG) Sequence H:  EVKLVESGGGLVKPGASLKLSCAASGFTFSNYGMSWVRQN SDKRLEWVASIRSGGGRTYYSDNVKGRFTISRENAKNTLY LQMSSLKSEDTALYYCVRYDSGSSDYWGQGTTVTVSSAKT TPPSVYPLAPSMVTLGCLVKGYFPEPVTVTWNSGSLSSGV HTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASS TKVDKKIVPR L:  YVVMTQTPLTLSVTIGQPASISCKSSQSLLDSDGKTYLNW LLQRPGQSPKRLIYLVSKLDSGVPDRFTGSGSGTDFTLKI SRIEAEDLGLYYCWQGTHFPRTFGGGTKLEIKRADAAPTV SIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSER QNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCE ATHKTSPIVKSFNR P:  DAEFR Description Functional site 1) chain H residue 213 type sequence D description BINDING SITE FOR RESIDUE ZN H 301 source : AC1 2) chain H residue 213 type sequence D description BINDING SITE FOR RESIDUE ZN H 301 source : AC1 3) chain H residue 62 type sequence D description BINDING SITE FOR RESIDUE ZN H 302 source : AC2 4) chain H residue 170 type sequence H description BINDING SITE FOR RESIDUE ZN H 303 source : AC3 5) chain L residue 172 type sequence D description BINDING SITE FOR RESIDUE ZN H 303 source : AC3 6) chain H residue 1 type sequence E description BINDING SITE FOR RESIDUE ZN H 306 source : AC6 7) chain H residue 179 type sequence D description BINDING SITE FOR RESIDUE ZN H 306 source : AC6 8) chain L residue 101 type sequence R description BINDING SITE FOR RESIDUE ZN H 307 source : AC7 9) chain P residue 1 type sequence D description BINDING SITE FOR RESIDUE ZN H 307 source : AC7 10) chain P residue 4 type sequence F description BINDING SITE FOR RESIDUE ZN H 307 source : AC7 11) chain H residue 65 type sequence K description BINDING SITE FOR RESIDUE ZN H 308 source : AC8 12) chain P residue 4 type sequence F description BINDING SITE FOR RESIDUE ZN H 309 source : AC9 13) chain H residue 113 type sequence T description BINDING SITE FOR RESIDUE ZN H 310 source : BC1 14) chain H residue 214 type sequence K description BINDING SITE FOR RESIDUE ZN H 311 source : BC2 15) chain H residue 44 type sequence R description BINDING SITE FOR RESIDUE ZN H 312 source : BC3 16) chain H residue 46 type sequence E description BINDING SITE FOR RESIDUE ZN H 312 source : BC3 17) chain H residue 200 type sequence T description BINDING SITE FOR RESIDUE IMD H 314 source : BC5 18) chain H residue 209 type sequence S description BINDING SITE FOR RESIDUE IMD H 314 source : BC5 19) chain H residue 211 type sequence K description BINDING SITE FOR RESIDUE IMD H 314 source : BC5 20) chain H residue 215 type sequence K description BINDING SITE FOR RESIDUE IMD H 314 source : BC5 21) chain H residue 60 type sequence Y description BINDING SITE FOR RESIDUE IMD H 315 source : BC6 22) chain H residue 62 type sequence D description BINDING SITE FOR RESIDUE IMD H 315 source : BC6 23) chain L residue 99 type sequence F description BINDING SITE FOR RESIDUE IMD H 315 source : BC6 24) chain H residue 206 type sequence P description BINDING SITE FOR RESIDUE CL H 316 source : BC7 25) chain H residue 161 type sequence N description BINDING SITE FOR RESIDUE CL H 318 source : BC9 26) chain H residue 162 type sequence S description BINDING SITE FOR RESIDUE CL H 318 source : BC9 27) chain H residue 202 type sequence N description BINDING SITE FOR RESIDUE CL H 318 source : BC9 28) chain H residue 211 type sequence K description BINDING SITE FOR RESIDUE CL H 319 source : CC1 29) chain H residue 213 type sequence D description BINDING SITE FOR RESIDUE CL H 319 source : CC1 30) chain H residue 59 type sequence Y description BINDING SITE FOR RESIDUE CL H 320 source : CC2 31) chain H residue 60 type sequence Y description BINDING SITE FOR RESIDUE CL H 320 source : CC2 32) chain H residue 65 type sequence K description BINDING SITE FOR RESIDUE CL H 320 source : CC2 33) chain H residue 65 type sequence K description BINDING SITE FOR RESIDUE CL H 320 source : CC2 34) chain L residue 1 type sequence Y description BINDING SITE FOR RESIDUE ZN L 301 source : CC3 35) chain L residue 98 type sequence H description BINDING SITE FOR RESIDUE ZN L 301 source : CC3 36) chain L residue 194 type sequence H description BINDING SITE FOR RESIDUE ZN L 302 source : CC4 37) chain L residue 115 type sequence D description BINDING SITE FOR RESIDUE ZN L 303 source : CC5 38) chain L residue 115 type sequence D description BINDING SITE FOR RESIDUE ZN L 303 source : CC5 39) chain L residue 203 type sequence H description BINDING SITE FOR RESIDUE ZN L 304 source : CC6 40) chain L residue 170 type sequence D description BINDING SITE FOR RESIDUE ZN L 306 source : CC8 41) chain L residue 154 type sequence K description BINDING SITE FOR RESIDUE ZN L 308 source : DC1 42) chain L residue 200 type sequence E description BINDING SITE FOR RESIDUE ZN L 308 source : DC1 43) chain L residue 84 type sequence E description BINDING SITE FOR RESIDUE ZN L 309 source : DC2 44) chain L residue 157 type sequence G description BINDING SITE FOR RESIDUE ZN L 311 source : DC4 45) chain L residue 196 type sequence S description BINDING SITE FOR RESIDUE ZN L 311 source : DC4 46) chain L residue 175 type sequence D description BINDING SITE FOR RESIDUE ZN L 312 source : DC5 47) chain L residue 31 type sequence D description BINDING SITE FOR RESIDUE ZN L 313 source : DC6 48) chain P residue 5 type sequence R description BINDING SITE FOR RESIDUE ZN L 313 source : DC6 49) chain H residue 170 type sequence H description BINDING SITE FOR RESIDUE ZN L 314 source : DC7 50) chain L residue 143 type sequence N description BINDING SITE FOR RESIDUE ZN L 314 source : DC7 51) chain L residue 172 type sequence D description BINDING SITE FOR RESIDUE ZN L 314 source : DC7 52) chain L residue 9 type sequence L description BINDING SITE FOR RESIDUE IMD L 315 source : DC8 53) chain L residue 105 type sequence G description BINDING SITE FOR RESIDUE IMD L 315 source : DC8 54) chain L residue 106 type sequence G description BINDING SITE FOR RESIDUE IMD L 315 source : DC8 55) chain L residue 116 type sequence A description BINDING SITE FOR RESIDUE CL L 316 source : DC9 56) chain L residue 117 type sequence A description BINDING SITE FOR RESIDUE CL L 316 source : DC9 57) chain L residue 203 type sequence H description BINDING SITE FOR RESIDUE CL L 316 source : DC9 58) chain L residue 203 type sequence H description BINDING SITE FOR RESIDUE CL L 317 source : EC1 59) chain L residue 170 type sequence D description BINDING SITE FOR RESIDUE CL L 318 source : EC2 60) chain L residue 194 type sequence H description BINDING SITE FOR RESIDUE CL L 319 source : EC3 61) chain L residue 194 type sequence H description BINDING SITE FOR RESIDUE CL L 320 source : EC4 62) chain L residue 156 type sequence D description BINDING SITE FOR RESIDUE CL L 321 source : EC5 63) chain L residue 157 type sequence G description BINDING SITE FOR RESIDUE CL L 321 source : EC5 64) chain L residue 196 type sequence S description BINDING SITE FOR RESIDUE CL L 321 source : EC5 65) chain L residue 198 type sequence T description BINDING SITE FOR RESIDUE CL L 321 source : EC5 66) chain H residue 34 type sequence M description BINDING SITE FOR CHAIN P OF AMYLOID BETA A4 PROTEIN source : EC6 67) chain H residue 35 type sequence S description BINDING SITE FOR CHAIN P OF AMYLOID BETA A4 PROTEIN source : EC6 68) chain H residue 50 type sequence S description BINDING SITE FOR CHAIN P OF AMYLOID BETA A4 PROTEIN source : EC6 69) chain H residue 51 type sequence I description BINDING SITE FOR CHAIN P OF AMYLOID BETA A4 PROTEIN source : EC6 70) chain H residue 52 type sequence R description BINDING SITE FOR CHAIN P OF AMYLOID BETA A4 PROTEIN source : EC6 71) chain H residue 59 type sequence Y description BINDING SITE FOR CHAIN P OF AMYLOID BETA A4 PROTEIN source : EC6 72) chain H residue 99 type sequence Y description BINDING SITE FOR CHAIN P OF AMYLOID BETA A4 PROTEIN source : EC6 73) chain H residue 105 type sequence S description BINDING SITE FOR CHAIN P OF AMYLOID BETA A4 PROTEIN source : EC6 74) chain H residue 106 type sequence S description BINDING SITE FOR CHAIN P OF AMYLOID BETA A4 PROTEIN source : EC6 75) chain L residue 31 type sequence D description BINDING SITE FOR CHAIN P OF AMYLOID BETA A4 PROTEIN source : EC6 76) chain L residue 37 type sequence Y description BINDING SITE FOR CHAIN P OF AMYLOID BETA A4 PROTEIN source : EC6 77) chain L residue 94 type sequence W description BINDING SITE FOR CHAIN P OF AMYLOID BETA A4 PROTEIN source : EC6 78) chain L residue 96 type sequence G description BINDING SITE FOR CHAIN P OF AMYLOID BETA A4 PROTEIN source : EC6 79) chain L residue 97 type sequence T description BINDING SITE FOR CHAIN P OF AMYLOID BETA A4 PROTEIN source : EC6 80) chain L residue 98 type sequence H description BINDING SITE FOR CHAIN P OF AMYLOID BETA A4 PROTEIN source : EC6 81) chain L residue 101 type sequence R description BINDING SITE FOR CHAIN P OF AMYLOID BETA A4 PROTEIN source : EC6 82) chain P residue 1 type SITE sequence D description Cleavage; by caspase-6; when associated with variant 670-N-L-671 source Swiss-Prot : SWS_FT_FI4 83) chain L residue 197-203 type prosite sequence YTCEATH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH source prosite : PS00290

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