eF-site ID 4omc-F PDB Code 4omc Chain F click to enlarge Title X-ray structure of human furin in complex with the competitive inhibitor meta-guanidinomethyl-Phac-RVR-Amba Classification HYDROLASE/HYDROLASE INHIBITOR Compound Furin Source Homo sapiens (Human) (4OMC) Sequence F:  YQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVV SILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQM NDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDG EVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARL AEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYT NSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEK QIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLT WRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLL DAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRK TVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPM GTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVL EIENTSEANNYGTLTKFTLVLYGTA Description (1)  Furin (E.C.3.4.21.75), meta-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine Functional site 1) chain F residue 276 type sequence R description BINDING SITE FOR RESIDUE FMT E 603 source : DC8 2) chain F residue 276 type sequence R description BINDING SITE FOR RESIDUE FMT E 604 source : DC9 3) chain F residue 313 type sequence Y description BINDING SITE FOR RESIDUE FMT F 601 source : EC5 4) chain F residue 447 type sequence Q description BINDING SITE FOR RESIDUE FMT F 601 source : EC5 5) chain F residue 275 type sequence F description BINDING SITE FOR RESIDUE FMT F 602 source : EC6 6) chain F residue 313 type sequence Y description BINDING SITE FOR RESIDUE FMT F 602 source : EC6 7) chain F residue 449 type sequence K description BINDING SITE FOR RESIDUE FMT F 602 source : EC6 8) chain F residue 295 type sequence N description BINDING SITE FOR RESIDUE FMT F 603 source : EC7 9) chain F residue 328 type sequence W description BINDING SITE FOR RESIDUE FMT F 603 source : EC7 10) chain F residue 365 type sequence T description BINDING SITE FOR RESIDUE FMT F 603 source : EC7 11) chain F residue 527 type sequence G description BINDING SITE FOR RESIDUE FMT F 604 source : EC8 12) chain F residue 528 type sequence F description BINDING SITE FOR RESIDUE FMT F 604 source : EC8 13) chain F residue 529 type sequence N description BINDING SITE FOR RESIDUE FMT F 604 source : EC8 14) chain F residue 115 type sequence D description BINDING SITE FOR RESIDUE CA F 605 source : EC9 15) chain F residue 162 type sequence D description BINDING SITE FOR RESIDUE CA F 605 source : EC9 16) chain F residue 205 type sequence V description BINDING SITE FOR RESIDUE CA F 605 source : EC9 17) chain F residue 208 type sequence N description BINDING SITE FOR RESIDUE CA F 605 source : EC9 18) chain F residue 210 type sequence V description BINDING SITE FOR RESIDUE CA F 605 source : EC9 19) chain F residue 212 type sequence G description BINDING SITE FOR RESIDUE CA F 605 source : EC9 20) chain F residue 258 type sequence D description BINDING SITE FOR RESIDUE CA F 606 source : FC1 21) chain F residue 301 type sequence D description BINDING SITE FOR RESIDUE CA F 606 source : FC1 22) chain F residue 331 type sequence E description BINDING SITE FOR RESIDUE CA F 606 source : FC1 23) chain F residue 174 type sequence D description BINDING SITE FOR RESIDUE CA F 607 source : FC2 24) chain F residue 179 type sequence D description BINDING SITE FOR RESIDUE CA F 607 source : FC2 25) chain F residue 181 type sequence D description BINDING SITE FOR RESIDUE CA F 607 source : FC2 26) chain F residue 309 type sequence T description BINDING SITE FOR RESIDUE NA F 608 source : FC3 27) chain F residue 311 type sequence S description BINDING SITE FOR RESIDUE NA F 608 source : FC3 28) chain F residue 314 type sequence T description BINDING SITE FOR RESIDUE NA F 608 source : FC3 29) chain F residue 154 type sequence D description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 30) chain F residue 191 type sequence D description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 31) chain F residue 192 type sequence N description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 32) chain F residue 194 type sequence H description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 33) chain F residue 231 type sequence V description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 34) chain F residue 232 type sequence T description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 35) chain F residue 236 type sequence E description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 36) chain F residue 253 type sequence S description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 37) chain F residue 254 type sequence W description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 38) chain F residue 255 type sequence G description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 39) chain F residue 256 type sequence P description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 40) chain F residue 258 type sequence D description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 41) chain F residue 264 type sequence D description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 42) chain F residue 265 type sequence G description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 43) chain F residue 292 type sequence A description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 44) chain F residue 295 type sequence N description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 45) chain F residue 306 type sequence D description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 46) chain F residue 308 type sequence Y description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 47) chain F residue 367 type sequence T description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 48) chain F residue 368 type sequence S description BINDING SITE FOR CHAIN N OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC9 49) chain F residue 153 type ACT_SITE sequence D description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 50) chain F residue 194 type ACT_SITE sequence H description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 51) chain F residue 368 type ACT_SITE sequence S description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 52) chain F residue 115 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 53) chain F residue 162 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 54) chain F residue 174 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 55) chain F residue 179 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 56) chain F residue 181 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 57) chain F residue 205 type BINDING sequence V description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 58) chain F residue 208 type BINDING sequence N description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 59) chain F residue 210 type BINDING sequence V description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 60) chain F residue 212 type BINDING sequence G description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 61) chain F residue 258 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 62) chain F residue 301 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 63) chain F residue 331 type BINDING sequence E description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 64) chain F residue 154 type BINDING sequence D description BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI3 65) chain F residue 191 type BINDING sequence D description BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI3 66) chain F residue 236 type BINDING sequence E description BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI3 67) chain F residue 253 type BINDING sequence S description BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI3 68) chain F residue 264 type BINDING sequence D description BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI3 69) chain F residue 292 type BINDING sequence A description BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI3 70) chain F residue 306 type BINDING sequence D description BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI3 71) chain F residue 308 type BINDING sequence Y description BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI3 72) chain F residue 368 type BINDING sequence S description BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI3 73) chain F residue 387 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 74) chain F residue 440 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 75) chain F residue 553 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI4

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