eF-site ID 4omc-D PDB Code 4omc Chain D click to enlarge Title X-ray structure of human furin in complex with the competitive inhibitor meta-guanidinomethyl-Phac-RVR-Amba Classification HYDROLASE/HYDROLASE INHIBITOR Compound Furin Source Homo sapiens (Human) (4OMC) Sequence D:  YQEPTDPKFPQQWYLSGVTQRDLNVKAAWAQGYTGHGIVV SILDDGIEKNHPDLAGNYDPGASFDVNDQDPDPQPRYTQM NDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDG EVTDAVEARSLGLNPNHIHIYSASWGPEDDGKTVDGPARL AEEAFFRGVSQGRGGLGSIFVWASGNGGREHDSCNCDGYT NSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEK QIVTTDLRQKCTESHTGTSASAPLAAGIIALTLEANKNLT WRDMQHLVVQTSKPAHLNANDWATNGVGRKVSHSYGYGLL DAGAMVALAQNWTTVAPQRKCIIDILTEPKDIGKRLEVRK TVTACLGEPNHITRLEHAQARLTLSYNRRGDLAIHLVSPM GTRSTLLAARPHDYSADGFNDWAFMTTHSWDEDPSGEWVL EIENTSEANNYGTLTKFTLVLYGTA Description (1)  Furin (E.C.3.4.21.75), meta-guanidinomethyl-phenylacetyl-Arg-Val-Arg-(amidomethyl)benzamidine Functional site 1) chain D residue 298 type sequence R description BINDING SITE FOR RESIDUE FMT B 603 source : BC2 2) chain D residue 276 type sequence R description BINDING SITE FOR RESIDUE FMT C 603 source : CC1 3) chain D residue 280 type sequence Q description BINDING SITE FOR RESIDUE FMT C 603 source : CC1 4) chain D residue 276 type sequence R description BINDING SITE FOR RESIDUE FMT C 604 source : CC2 5) chain D residue 313 type sequence Y description BINDING SITE FOR RESIDUE FMT D 601 source : CC7 6) chain D residue 447 type sequence Q description BINDING SITE FOR RESIDUE FMT D 601 source : CC7 7) chain D residue 275 type sequence F description BINDING SITE FOR RESIDUE FMT D 602 source : CC8 8) chain D residue 313 type sequence Y description BINDING SITE FOR RESIDUE FMT D 602 source : CC8 9) chain D residue 449 type sequence K description BINDING SITE FOR RESIDUE FMT D 602 source : CC8 10) chain D residue 571 type sequence Y description BINDING SITE FOR RESIDUE FMT D 602 source : CC8 11) chain D residue 365 type sequence T description BINDING SITE FOR RESIDUE FMT D 603 source : CC9 12) chain D residue 366 type sequence G description BINDING SITE FOR RESIDUE FMT D 603 source : CC9 13) chain D residue 527 type sequence G description BINDING SITE FOR RESIDUE FMT D 604 source : DC1 14) chain D residue 528 type sequence F description BINDING SITE FOR RESIDUE FMT D 604 source : DC1 15) chain D residue 529 type sequence N description BINDING SITE FOR RESIDUE FMT D 604 source : DC1 16) chain D residue 115 type sequence D description BINDING SITE FOR RESIDUE CA D 605 source : DC2 17) chain D residue 162 type sequence D description BINDING SITE FOR RESIDUE CA D 605 source : DC2 18) chain D residue 205 type sequence V description BINDING SITE FOR RESIDUE CA D 605 source : DC2 19) chain D residue 208 type sequence N description BINDING SITE FOR RESIDUE CA D 605 source : DC2 20) chain D residue 210 type sequence V description BINDING SITE FOR RESIDUE CA D 605 source : DC2 21) chain D residue 212 type sequence G description BINDING SITE FOR RESIDUE CA D 605 source : DC2 22) chain D residue 258 type sequence D description BINDING SITE FOR RESIDUE CA D 606 source : DC3 23) chain D residue 301 type sequence D description BINDING SITE FOR RESIDUE CA D 606 source : DC3 24) chain D residue 331 type sequence E description BINDING SITE FOR RESIDUE CA D 606 source : DC3 25) chain D residue 174 type sequence D description BINDING SITE FOR RESIDUE CA D 607 source : DC4 26) chain D residue 179 type sequence D description BINDING SITE FOR RESIDUE CA D 607 source : DC4 27) chain D residue 181 type sequence D description BINDING SITE FOR RESIDUE CA D 607 source : DC4 28) chain D residue 309 type sequence T description BINDING SITE FOR RESIDUE NA D 608 source : DC5 29) chain D residue 311 type sequence S description BINDING SITE FOR RESIDUE NA D 608 source : DC5 30) chain D residue 314 type sequence T description BINDING SITE FOR RESIDUE NA D 608 source : DC5 31) chain D residue 154 type sequence D description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 32) chain D residue 191 type sequence D description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 33) chain D residue 192 type sequence N description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 34) chain D residue 194 type sequence H description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 35) chain D residue 231 type sequence V description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 36) chain D residue 232 type sequence T description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 37) chain D residue 233 type sequence D description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 38) chain D residue 236 type sequence E description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 39) chain D residue 253 type sequence S description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 40) chain D residue 254 type sequence W description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 41) chain D residue 255 type sequence G description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 42) chain D residue 256 type sequence P description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 43) chain D residue 258 type sequence D description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 44) chain D residue 264 type sequence D description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 45) chain D residue 265 type sequence G description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 46) chain D residue 292 type sequence A description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 47) chain D residue 306 type sequence D description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 48) chain D residue 308 type sequence Y description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 49) chain D residue 309 type sequence T description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 50) chain D residue 367 type sequence T description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 51) chain D residue 368 type sequence S description BINDING SITE FOR CHAIN K OF META-GUANIDINOMETHYL-PHENYLACETYL-ARG-VAL-ARG- (AMIDOMETHYL)BENZAMIDINE source : FC7 52) chain D residue 153 type ACT_SITE sequence D description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 53) chain D residue 194 type ACT_SITE sequence H description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 54) chain D residue 368 type ACT_SITE sequence S description Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 source Swiss-Prot : SWS_FT_FI1 55) chain D residue 115 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 56) chain D residue 162 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 57) chain D residue 174 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 58) chain D residue 179 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 59) chain D residue 181 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 60) chain D residue 205 type BINDING sequence V description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 61) chain D residue 208 type BINDING sequence N description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 62) chain D residue 210 type BINDING sequence V description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 63) chain D residue 212 type BINDING sequence G description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 64) chain D residue 258 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 65) chain D residue 301 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 66) chain D residue 331 type BINDING sequence E description BINDING => ECO:0000269|PubMed:24666235, ECO:0000269|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI2 67) chain D residue 154 type BINDING sequence D description BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI3 68) chain D residue 191 type BINDING sequence D description BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI3 69) chain D residue 236 type BINDING sequence E description BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI3 70) chain D residue 253 type BINDING sequence S description BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI3 71) chain D residue 264 type BINDING sequence D description BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI3 72) chain D residue 292 type BINDING sequence A description BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI3 73) chain D residue 306 type BINDING sequence D description BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI3 74) chain D residue 308 type BINDING sequence Y description BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI3 75) chain D residue 368 type BINDING sequence S description BINDING => ECO:0000305|PubMed:24666235, ECO:0000305|PubMed:25974265, ECO:0007744|PDB:4OMC, ECO:0007744|PDB:4OMD, ECO:0007744|PDB:4RYD source Swiss-Prot : SWS_FT_FI3 76) chain D residue 387 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 77) chain D residue 440 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI4 78) chain D residue 553 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI4

Display surface Download Links