eF-site ID 4olg-AB PDB Code 4olg Chain A, B click to enlarge Title Crystal structure of AmpC beta-lactamase in complex with covalently bound N-formyl 7-aminocephalosporanic acid Classification HYDROLASE Compound Beta-lactamase Source Escherichia coli (strain K12) (AMPC_ECOLI) Sequence A:  APQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTW GYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEI KLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPD EVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAV KPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGY REGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDI NEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSI INGSDIALAARPVKAITPPTPAVRASWVHKTGATGGFGSY VAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ B:  APQQINDIVHRTITPLIEQQKIPGMAVAVIYQGKPYYFTW GYADIAKKQPVTQQTLFELGSVSKTFTGVLGGDAIARGEI KLSDPTTKYWPELTAKQWNGITLLHLATYTAGGLPLQVPD EVKSSSDLLRFYQNWQPAWAPGTQRLYANSSIGLFGALAV KPSGLSFEQAMQTRVFQPLKLNHTWINVPPAEEKNYAWGY REGKAVHVSPGALDAEAYGVKSTIEDMARWVQSNLKPLDI NEKTLQQGIQLAQSRYWQTGDMYQGLGWEMLDWPVNPDSI INGSDNKIALAARPVKAITPPTPAVRASWVHKTGATGGFG SYVAFIPEKELGIVMLANKNYPNPARVDAAWQILNALQ Description (1)  Beta-lactamase (E.C.3.5.2.6) Functional site 1) chain A residue 64 type sequence S description BINDING SITE FOR RESIDUE 2TV A 401 source : AC1 2) chain A residue 119 type sequence L description BINDING SITE FOR RESIDUE 2TV A 401 source : AC1 3) chain A residue 150 type sequence Y description BINDING SITE FOR RESIDUE 2TV A 401 source : AC1 4) chain A residue 291 type sequence I description BINDING SITE FOR RESIDUE 2TV A 401 source : AC1 5) chain A residue 316 type sequence T description BINDING SITE FOR RESIDUE 2TV A 401 source : AC1 6) chain A residue 317 type sequence G description BINDING SITE FOR RESIDUE 2TV A 401 source : AC1 7) chain A residue 318 type sequence A description BINDING SITE FOR RESIDUE 2TV A 401 source : AC1 8) chain A residue 346 type sequence N description BINDING SITE FOR RESIDUE 2TV A 401 source : AC1 9) chain A residue 186 type sequence H description BINDING SITE FOR RESIDUE PO4 A 402 source : AC2 10) chain B residue 290 type sequence K description BINDING SITE FOR RESIDUE PO4 A 402 source : AC2 11) chain B residue 64 type sequence S description BINDING SITE FOR RESIDUE 2TV B 401 source : AC3 12) chain B residue 119 type sequence L description BINDING SITE FOR RESIDUE 2TV B 401 source : AC3 13) chain B residue 150 type sequence Y description BINDING SITE FOR RESIDUE 2TV B 401 source : AC3 14) chain B residue 289 type sequence N description BINDING SITE FOR RESIDUE 2TV B 401 source : AC3 15) chain B residue 293 type sequence L description BINDING SITE FOR RESIDUE 2TV B 401 source : AC3 16) chain B residue 317 type sequence G description BINDING SITE FOR RESIDUE 2TV B 401 source : AC3 17) chain B residue 318 type sequence A description BINDING SITE FOR RESIDUE 2TV B 401 source : AC3 18) chain B residue 346 type sequence N description BINDING SITE FOR RESIDUE 2TV B 401 source : AC3 19) chain A residue 64 type ACT_SITE sequence S description Acyl-ester intermediate => ECO:0000255|PROSITE-ProRule:PRU10102, ECO:0000269|PubMed:6795623 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 64 type ACT_SITE sequence S description Acyl-ester intermediate => ECO:0000255|PROSITE-ProRule:PRU10102, ECO:0000269|PubMed:6795623 source Swiss-Prot : SWS_FT_FI1 21) chain A residue 150 type ACT_SITE sequence Y description Proton acceptor source Swiss-Prot : SWS_FT_FI2 22) chain B residue 150 type ACT_SITE sequence Y description Proton acceptor source Swiss-Prot : SWS_FT_FI2 23) chain A residue 315 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 24) chain B residue 315 type BINDING sequence K description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 25) chain A residue 60-67 type prosite sequence FELGSVSK description BETA_LACTAMASE_C Beta-lactamase class-C active site. FELGSVSK source prosite : PS00336

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