eF-site ID 4ola-AB PDB Code 4ola Chain A, B click to enlarge Title Crystal Structure of Human Argonaute2 Classification HYDROLASE/RNA Compound Protein argonaute-2 Source null (4OLA) Sequence A:  FKPPPRPDFGTSGRTIKLQANFFEMDIPKIDIYHYELDIK PEKCPRRVNREIVEHMVQHFKTQIFGDRKPVFDGRKNLYT AMPLPIGRDKVELEVTLRIFKVSIKWVSCVSLQALHDALS GRLVPFETIQALDVVMRHLPSMRYTPVGRSFFTASSNPLG GGREVWFGFHQSVRPSLWKMMLNIDVSATAFYKAQPVIEF VCEVLDFKSIEQKPLTDSQRVKFTKEIKGLKVEITRKYRV CNVTRRPASHQTFPLQQESGQTVECTVAQYFKDRHKLVLR YPHLPCLQVGQEHTYLPLEVCNIVAGQRCIKKLTDNQTST MIRATARSAPDRQEEISKLMRSADFNTDPYVREFGIMVKD EMTDVTGRVLQPPSILYGGRNKAIATPVQGVWDMRNKQFH TGIEIKVWAIACFAPQRQCTEVHLKSFTEQLRKISRDAGM PIQGQPCFCKYAQGADSVEPMFRHLKNTYAGLQLVVVILP GKTPVYAEVKRVGDTVLGMATQCVQMKNVQRTTPQTLSNL CLKINVKLGGVNNILLPQGRPPVFQQPVIFLGADVTHPKP SIAAVVGSMDAHPNRYCATVRVQQHRQEIIQDLAAMVREL LIQFYKSTRFKPTRIIFYRDGVSEGQFQQVLHHELLAIRE ACIKLEKDYQPGITFIVVQKRHHTRLFCTDKNERVGKSGN IPAGTTVDTKITHPTEFDFYLCSHAGIQGTSRPSHYHVLW DDNRFSSDELQILTYQLCHTYVRCTRSVSIPAPAYYAHLV AFRARYHLHQALAKAVQVHQDTLRTMYFA B:  AAAAAAAAAU Description Functional site 1) chain A residue 650 type sequence L description BINDING SITE FOR RESIDUE IPH A 901 source : AC1 2) chain A residue 654 type sequence Y description BINDING SITE FOR RESIDUE IPH A 901 source : AC1 3) chain A residue 660 type sequence K description BINDING SITE FOR RESIDUE IPH A 901 source : AC1 4) chain A residue 694 type sequence L description BINDING SITE FOR RESIDUE IPH A 901 source : AC1 5) chain A residue 320 type sequence L description BINDING SITE FOR RESIDUE IPA A 902 source : AC2 6) chain A residue 322 type sequence Y description BINDING SITE FOR RESIDUE IPA A 902 source : AC2 7) chain A residue 325 type sequence L description BINDING SITE FOR RESIDUE IPA A 902 source : AC2 8) chain A residue 326 type sequence P description BINDING SITE FOR RESIDUE IPA A 902 source : AC2 9) chain A residue 340 type sequence P description BINDING SITE FOR RESIDUE IPA A 902 source : AC2 10) chain A residue 341 type sequence L description BINDING SITE FOR RESIDUE IPA A 902 source : AC2 11) chain A residue 342 type sequence E description BINDING SITE FOR RESIDUE IPA A 902 source : AC2 12) chain A residue 597 type BINDING sequence D description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 13) chain A residue 669 type BINDING sequence D description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 807 type BINDING sequence H description BINDING => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 387 type MOD_RES sequence D description Phosphoserine => ECO:0000269|PubMed:23603119, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI3 16) chain A residue 700 type MOD_RES sequence P description 4-hydroxyproline => ECO:0000255|HAMAP-Rule:MF_03031, ECO:0000269|PubMed:18690212 source Swiss-Prot : SWS_FT_FI4

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