eF-site ID 4oir-D PDB Code 4oir Chain D click to enlarge Title Crystal structure of Thermus thermophilus RNA polymerase transcription initiation complex soaked with GE23077 and rifamycin SV Classification TRANSCRIPTION, TRANSFERASE/ANTIBIOTIC Compound DNA-directed RNA polymerase subunit alpha Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence D:  KEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERD GLFDERIFGPIKDYECACGKYKRQRFEGKVCERCGVEVTK SIVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSATE LEQVLYFSKYIVLDPKGAILNGVPVEKRQLLTDEEYRELR YGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDGV ALYRFPRRVRVEYVKKERAGLRLPLAAWVEKEAYKPGEIL AELPEPYLFRAEEEGVVELKELEEGAFLVLRREDEPVATY FLPVGMTPLVVHGEIVEKGQPLAEAKGLLRMPRQVRAAQV EAEEEGETVYLTLFLEWTEPKDYRVQPHMNVVVPEGARVE AGDKIVAAIDPEEEVIAEAEGVVHLHEPASILVVKARVYP FEDDVEVSTGDRVAPGDVLADGGKVKSDVYGRVEVDLVRN VVRVVESYDIDARMGAEAIQQLLKELDLEALEKELLEEMK HPSRARRAKARKRLEVVRAFLDSGNRPEWMILEAVPVLPP DLRPMVQVDGGRFATSDLNDLYRRLINRNNRLKKLLAQGA PEIIIRNEKRMLQEAVDALLDNGRRGAPVTNPGSDRPLRS LTDILSGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQC GLPKRMALELFKPFLLKKMEEKGIAPNVKAARRMLERQRD IKDEVWDALEEVIHGKVVLLNRAPTLHRLGIQAFQPVLVE GQSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARIQ MLSAHNLLSPASGEPLAKPSRDIILGLYYITQVRKEKKGA GLEFATPEEALAAHERGEVALNAPIKVAGRETSVGRLKYV FANPDEALLAVAHGIVDLQDVVTVRYMGKRLETSPGRILF ARIVAEAVEDEKVAWELIQLDVPQEKNSLKDLVYQAFLRL GMEKTARLLDALKYYGFTFSTTSGITIGIDDAVIPEEKKQ YLEEADRKLLQIEQAYEMGFLTDRERYDQILQLWTETTEK VTQAVFKNFEENYPFNPLYVMAQSGARGNPQQIRQLCGLR GLMQKPSGETFEVPVRSSFREGLTVLEYFISSHGARKGGA DTALRTADSGYLTRKLVDVTHEIVVREADCGTTNYISVPL FQPDEVTRSLRLRKRADIEAGLYGRVLAREVEVLGVRLEE GRYLSMDDVHLLIKAAEAGEIQEVPVRSPLTCQTRYGVCQ KCYGYDLSMARPVSIGEAVGIVAAQSIGEPGTQLTMQGLP RVIELFEARRPKAKAVISEIDGVVRIEETEEKLSVFVESE GFSKEYKLPKEARLLVKDGDYVEAGQPLTRGAIDPHQLLE AKGPEAVERYLVEEIQKVYRAQGVKLHDKHIEIVVRQMMK YVEVTDPGDSRLLEGQVLEKWDVEALNERLIAEGKTPVAW KPLLMGVTKSALSTKSWLSAASFQNTTHVLTEAAIAGKKD ELIGLKENVILGRLIPAGTGSDFVRFTQVVDQKTLKAIEE ARKEA Description Functional site 1) chain D residue 840 type sequence K description BINDING SITE FOR RESIDUE MG B 401 source : AC1 2) chain D residue 1112 type sequence C description BINDING SITE FOR RESIDUE ZN D 2001 source : AC3 3) chain D residue 1194 type sequence C description BINDING SITE FOR RESIDUE ZN D 2001 source : AC3 4) chain D residue 1201 type sequence C description BINDING SITE FOR RESIDUE ZN D 2001 source : AC3 5) chain D residue 1204 type sequence C description BINDING SITE FOR RESIDUE ZN D 2001 source : AC3 6) chain D residue 58 type sequence C description BINDING SITE FOR RESIDUE ZN D 2002 source : AC4 7) chain D residue 60 type sequence C description BINDING SITE FOR RESIDUE ZN D 2002 source : AC4 8) chain D residue 73 type sequence C description BINDING SITE FOR RESIDUE ZN D 2002 source : AC4 9) chain D residue 76 type sequence C description BINDING SITE FOR RESIDUE ZN D 2002 source : AC4 10) chain D residue 739 type sequence D description BINDING SITE FOR RESIDUE MG D 2003 source : AC5 11) chain D residue 741 type sequence D description BINDING SITE FOR RESIDUE MG D 2003 source : AC5 12) chain D residue 743 type sequence D description BINDING SITE FOR RESIDUE MG D 2003 source : AC5 13) chain D residue 897 type sequence W description BINDING SITE FOR RESIDUE MG D 2004 source : AC6 14) chain D residue 900 type sequence I description BINDING SITE FOR RESIDUE MG D 2004 source : AC6 15) chain D residue 58 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 16) chain D residue 1201 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 17) chain D residue 1204 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 18) chain D residue 60 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 19) chain D residue 73 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 20) chain D residue 76 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 21) chain D residue 739 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 22) chain D residue 741 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 23) chain D residue 743 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 24) chain D residue 1112 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 25) chain D residue 1194 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1

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