eF-site ID 4oir-C PDB Code 4oir Chain C click to enlarge Title Crystal structure of Thermus thermophilus RNA polymerase transcription initiation complex soaked with GE23077 and rifamycin SV Classification TRANSCRIPTION, TRANSFERASE/ANTIBIOTIC Compound DNA-directed RNA polymerase subunit alpha Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence C:  MEIKRFGRIREVIPLPPLTEIQVESYRRALQADVPPEKRE NVGIQAAFRETFPIEEGLVLDFLEYRLGEPPFPQDECREK DLTYQAPLYARLQLIHKDTGLIKEDEVFLGHIPLMTEDGS FIINGADRVIVSQIHRSPGVYFTPDPARPGRYIASIIPLP KRGPWIDLEVEPNGVVSMKVNKRKFPLVLLLRVLGYDQET LARELGAYGELVQGLMDESVFAMRPEEALIRLFTLLRPGD PPKRDKAVAYVYGLIADPRRYDLGEAGRYKAEEKLGIRLS GRTLARFEDGEFKDEVFLPTLRYLFALTAGVPGHEVDDID HLGNRRIRTVGELMTDQFRVGLARLARGVRERMLMGSEDS LTPAKLVNSRPLEAAIREFFSRSQLSQFKDETNPLSSLRH KRRISALGPGGLTRERAGFDVRDVHRTHYGRICPVETPEG ANIGLITSLAAYARVDELGFIRTPYRRVVGGVVTDEVVYM TATEEDRYTIAQANTPLEGNRIAAERVVARRKGEPVIVSP EEVEFMDVSPKQVFSVNTNLIPFLEHDDANRALMGSNMQT QAVPLIRAQAPVVMTGLEERVVRDSLAALYAEEDGEVAKV DGNRIVVRYEDGRLVEYPLRRFYRSNQGTALDQRPRVVVG QRVRKGDLLADGPASENGFLALGQNVLVAIMPFDGYNFED AIVISEELLKRDFYTSIHIERYEIEARDTKLGPERITRDI PHLSEAALRDLDEEGVVRIGAEVKPGDILVGRTSFKGESE PTPEERLLRSIFGEKARDVKDTSLRVPPGEGGIVVRTVRL RRGDPGVELKPGVREVVRVYVAQKRKLQVGDKLANRHGNK GVVAKILPVEDMPHLPDGTPVDVILNPLGVPSRMNLGQIL ETHLGLAGYFLGQRYISPIFDGAKEPEIKELLAQAFEVYF GKRKGEGFGVDKREVEVLRRAEKLGLVTPGKTPEEQLKEL FLQGKVVLYDGRTGEPIEGPIVVGQMFIMKLYHMVEDKMH ARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAA HTLQEMLTLKSDDIEGRNAAYEAIIKGEDVPEPSVPESFR VLVKELQALALDVQTLDEKDNPVDIFEGLASK Description Functional site 1) chain C residue 390 type sequence Q description BINDING SITE FOR RESIDUE RFV C 1201 source : AC2 2) chain C residue 392 type sequence S description BINDING SITE FOR RESIDUE RFV C 1201 source : AC2 3) chain C residue 393 type sequence Q description BINDING SITE FOR RESIDUE RFV C 1201 source : AC2 4) chain C residue 394 type sequence F description BINDING SITE FOR RESIDUE RFV C 1201 source : AC2 5) chain C residue 405 type sequence R description BINDING SITE FOR RESIDUE RFV C 1201 source : AC2 6) chain C residue 406 type sequence H description BINDING SITE FOR RESIDUE RFV C 1201 source : AC2 7) chain C residue 409 type sequence R description BINDING SITE FOR RESIDUE RFV C 1201 source : AC2 8) chain C residue 411 type sequence S description BINDING SITE FOR RESIDUE RFV C 1201 source : AC2 9) chain C residue 420 type sequence R description BINDING SITE FOR RESIDUE RFV C 1201 source : AC2 10) chain C residue 448 type sequence N description BINDING SITE FOR RESIDUE RFV C 1201 source : AC2 11) chain C residue 452 type sequence I description BINDING SITE FOR RESIDUE RFV C 1201 source : AC2 12) chain C residue 445 type sequence E description BINDING SITE FOR GE23077 source : AC8 13) chain C residue 446 type sequence G description BINDING SITE FOR GE23077 source : AC8 14) chain C residue 557 type sequence R description BINDING SITE FOR GE23077 source : AC8 15) chain C residue 560 type sequence M description BINDING SITE FOR GE23077 source : AC8 16) chain C residue 563 type sequence N description BINDING SITE FOR GE23077 source : AC8 17) chain C residue 567 type sequence Q description BINDING SITE FOR GE23077 source : AC8 18) chain C residue 838 type sequence K description BINDING SITE FOR GE23077 source : AC8 19) chain C residue 846 type sequence K description BINDING SITE FOR GE23077 source : AC8 20) chain C residue 836-848 type prosite sequence GDKLANRHGNKGV description RNA_POL_BETA RNA polymerases beta chain signature. GdKLANrHGNKGV source prosite : PS01166

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