eF-site ID 4oiq-C PDB Code 4oiq Chain C click to enlarge Title Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077 and rifampicin Classification TRANSCRIPTION, TRANSFERASE/ANTIBIOTIC Compound DNA-directed RNA polymerase subunit alpha Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence C:  MEIKRFGRIREVIPLPPLTEIQVESYRRALQADVPPEKRE NVGIQAAFRETFPIEEGLVLDFLEYRLGEPPFPQDECREK DLTYQAPLYARLQLIHKDTGLIKEDEVFLGHIPLMTEDGS FIINGADRVIVSQIHRSPGVYFTPDPARPGRYIASIIPLP KRGPWIDLEVEPNGVVSMKVNKRKFPLVLLLRVLGYDQET LARELGAYGELVQGLMDESVFAMRPEEALIRLFTLLRPGD PPKRDKAVAYVYGLIADPRRYDLGEAGRYKAEEKLGIRLS GRTLARFEDGEFKDEVFLPTLRYLFALTAGVPGHEVDDID HLGNRRIRTVGELMTDQFRVGLARLARGVRERMLMGSEDS LTPAKLVNSRPLEAAIREFFSRSQLSQFKDETNPLSSLRH KRRISALGPGGLTRERAGFDVRDVHRTHYGRICPVETPEG ANIGLITSLAAYARVDELGFIRTPYRRVVGGVVTDEVVYM TATEEDRYTIAQANTPLEGNRIAAERVVARRKGEPVIVSP EEVEFMDVSPKQVFSVNTNLIPFLEHDDANRALMGSNMQT QAVPLIRAQAPVVMTGLEERVVRDSLAALYAEEDGEVAKV DGNRIVVRYEDGRLVEYPLRRFYRSNQGTALDQRPRVVVG QRVRKGDLLADGPASENGFLALGQNVLVAIMPFDGYNFED AIVISEELLKRDFYTSIHIERYEIEARDTKLGPERITRDI PHLSEAALRDLDEEGVVRIGAEVKPGDILVGRTSFKGESE PTPEERLLRSIFGEKARDVKDTSLRVPPGEGGIVVRTVRL RRGDPGVELKPGVREVVRVYVAQKRKLQVGDKLANRHGNK GVVAKILPVEDMPHLPDGTPVDVILNPLGVPSRMNLGQIL ETHLGLAGYFLGQRYISPIFDGAKEPEIKELLAQAFEVYF GKRKGEGFGVDKREVEVLRRAEKLGLVTPGKTPEEQLKEL FLQGKVVLYDGRTGEPIEGPIVVGQMFIMKLYHMVEDKMH ARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAA HTLQEMLTLKSDDIEGRNAAYEAIIKGEDVPEPSVPESFR VLVKELQALALDVQTLDEKDNPVDIFEGLASK Description Functional site 1) chain C residue 8 type sequence R description BINDING SITE FOR GE23077 source : AC7 2) chain C residue 9 type sequence I description BINDING SITE FOR GE23077 source : AC7 3) chain C residue 445 type sequence E description BINDING SITE FOR GE23077 source : AC7 4) chain C residue 446 type sequence G description BINDING SITE FOR GE23077 source : AC7 5) chain C residue 557 type sequence R description BINDING SITE FOR GE23077 source : AC7 6) chain C residue 560 type sequence M description BINDING SITE FOR GE23077 source : AC7 7) chain C residue 563 type sequence N description BINDING SITE FOR GE23077 source : AC7 8) chain C residue 567 type sequence Q description BINDING SITE FOR GE23077 source : AC7 9) chain C residue 838 type sequence K description BINDING SITE FOR GE23077 source : AC7 10) chain C residue 846 type sequence K description BINDING SITE FOR GE23077 source : AC7 11) chain C residue 898 type sequence G description BINDING SITE FOR GE23077 source : AC7 12) chain C residue 899 type sequence Q description BINDING SITE FOR GE23077 source : AC7 13) chain C residue 900 type sequence R description BINDING SITE FOR GE23077 source : AC7 14) chain C residue 901 type sequence Y description BINDING SITE FOR GE23077 source : AC7 15) chain C residue 902 type sequence I description BINDING SITE FOR GE23077 source : AC7 16) chain C residue 904 type sequence P description BINDING SITE FOR GE23077 source : AC7 17) chain C residue 907 type sequence D description BINDING SITE FOR GE23077 source : AC7 18) chain C residue 908 type sequence G description BINDING SITE FOR GE23077 source : AC7 19) chain C residue 909 type sequence A description BINDING SITE FOR GE23077 source : AC7 20) chain C residue 917 type sequence L description BINDING SITE FOR GE23077 source : AC7 21) chain C residue 836-848 type prosite sequence GDKLANRHGNKGV description RNA_POL_BETA RNA polymerases beta chain signature. GdKLANrHGNKGV source prosite : PS01166

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