eF-site ID 4oip-D PDB Code 4oip Chain D click to enlarge Title Crystal structure of Thermus thermophilus transcription initiation complex soaked with GE23077, ATP, and CMPcPP Classification TRANSCRIPTION, TRANSFERASE/ANTIBIOTIC Compound DNA-directed RNA polymerase subunit alpha Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence D:  KEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERD GLFDERIFGPIKDYECACGKYKRQRFEGKVCERCGVEVTK SIVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSATE LEQVLYFSKYIVLDPKGAILNGVPVEKRQLLTDEEYRELR YGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDGV ALYRFPRRVRVEYVKKERAGLRLPLAAWVEKEAYKPGEIL AELPEPYLFRAEEEGVVELKELEEGAFLVLRREDEPVATY FLPVGMTPLVVHGEIVEKGQPLAEAKGLLRMPRQVRAAQV EAEEEGETVYLTLFLEWTEPKDYRVQPHMNVVVPEGARVE AGDKIVAAIDPEEEVIAEAEGVVHLHEPASILVVKARVYP FEDDVEVSTGDRVAPGDVLADGGKVKSDVYGRVEVDLVRN VVRVVESYDIDARMGAEAIQQLLKELDLEALEKELLEEMK HPSRARRAKARKRLEVVRAFLDSGNRPEWMILEAVPVLPP DLRPMVQVDGGRFATSDLNDLYRRLINRNNRLKKLLAQGA PEIIIRNEKRMLQEAVDALLDNGRRGAPVTNPGSDRPLRS LTDILSGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQC GLPKRMALELFKPFLLKKMEEKGIAPNVKAARRMLERQRD IKDEVWDALEEVIHGKVVLLNRAPTLHRLGIQAFQPVLVE GQSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARIQ MLSAHNLLSPASGEPLAKPSRDIILGLYYITQVRKEKKGA GLEFATPEEALAAHERGEVALNAPIKVAGRETSVGRLKYV FANPDEALLAVAHGIVDLQDVVTVRYMGKRLETSPGRILF ARIVAEAVEDEKVAWELIQLDVPQEKNSLKDLVYQAFLRL GMEKTARLLDALKYYGFTFSTTSGITIGIDDAVIPEEKKQ YLEEADRKLLQIEQAYEMGFLTDRERYDQILQLWTETTEK VTQAVFKNFEENYPFNPLYVMAQSGARGNPQQIRQLCGLR GLMQKPSGETFEVPVRSSFREGLTVLEYFISSHGARKGGA DTALRTADSGYLTRKLVDVTHEIVVREADCGTTNYISVPL FQPDEVTRSLRLRKRADIEAGLYGRVLAREVEVLGVRLEE GRYLSMDDVHLLIKAAEAGEIQEVPVRSPLTCQTRYGVCQ KCYGYDLSMARPVSIGEAVGIVAAQSIGEPGTQLTITQGL PRVIELFEARRPKAKAVISEIDGVVRIEETEEKLSVFVES EGFSKEYKLPKEARLLVKDGDYVEAGQPLTRGAIDPHQLL EAKGPEAVERYLVEEIQKVYRAQGVKLHDKHIEIVVRQMM KYVEVTDPGDSRLLEGQVLEKWDVEALNERLIAEGKTPVA WKPLLMGVTKSALSTKSWLSAASFQNTTHVLTEAAIAGKK DELIGLKENVILGRLIPAGTGSDFVRFTQVVDQKTLKAIE EARKEA Description Functional site 1) chain D residue 1112 type sequence C description BINDING SITE FOR RESIDUE ZN D 2001 source : AC2 2) chain D residue 1194 type sequence C description BINDING SITE FOR RESIDUE ZN D 2001 source : AC2 3) chain D residue 1201 type sequence C description BINDING SITE FOR RESIDUE ZN D 2001 source : AC2 4) chain D residue 1204 type sequence C description BINDING SITE FOR RESIDUE ZN D 2001 source : AC2 5) chain D residue 58 type sequence C description BINDING SITE FOR RESIDUE ZN D 2002 source : AC3 6) chain D residue 60 type sequence C description BINDING SITE FOR RESIDUE ZN D 2002 source : AC3 7) chain D residue 73 type sequence C description BINDING SITE FOR RESIDUE ZN D 2002 source : AC3 8) chain D residue 76 type sequence C description BINDING SITE FOR RESIDUE ZN D 2002 source : AC3 9) chain D residue 739 type sequence D description BINDING SITE FOR RESIDUE MG D 2003 source : AC4 10) chain D residue 741 type sequence D description BINDING SITE FOR RESIDUE MG D 2003 source : AC4 11) chain D residue 743 type sequence D description BINDING SITE FOR RESIDUE MG D 2003 source : AC4 12) chain D residue 739 type sequence D description BINDING SITE FOR RESIDUE MG D 2004 source : AC5 13) chain D residue 840 type sequence K description BINDING SITE FOR RESIDUE MG D 2005 source : AC6 14) chain D residue 897 type sequence W description BINDING SITE FOR RESIDUE MG D 2006 source : AC7 15) chain D residue 900 type sequence I description BINDING SITE FOR RESIDUE MG D 2006 source : AC7 16) chain D residue 783 type sequence R description BINDING SITE FOR RESIDUE ATP D 2007 source : AC8 17) chain D residue 1029 type sequence R description BINDING SITE FOR RESIDUE ATP D 2007 source : AC8 18) chain D residue 58 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 19) chain D residue 1201 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 20) chain D residue 1204 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 21) chain D residue 60 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 22) chain D residue 73 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 23) chain D residue 76 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 24) chain D residue 739 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 25) chain D residue 741 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 26) chain D residue 743 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 27) chain D residue 1112 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 28) chain D residue 1194 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1

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