eF-site ID 4oio-D PDB Code 4oio Chain D click to enlarge Title Crystal structure of Thermus thermophilus pre-insertion substrate complex for de novo transcription initiation Classification TRANSCRIPTION, TRANSFERASE Compound DNA-directed RNA polymerase subunit alpha Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence D:  KEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPERD GLFDERIFGPIKDYECACGKYKRQRFEGKVCERCGVEVTK SIVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSATE LEQVLYFSKYIVLDPKGAILNGVPVEKRQLLTDEEYRELR YGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDGV ALYRFPRRVRVEYVKKERAGLRLPLAAWVEKEAYKPGEIL AELPEPYLFRAEEEGVVELKELEEGAFLVLRREDEPVATY FLPVGMTPLVVHGEIVEKGQPLAEAKGLLRMPRQVRAAQV EAEEEGETVYLTLFLEWTEPKDYRVQPHMNVVVPEGARVE AGDKIVAAIDPEEEVIAEAEGVVHLHEPASILVVKARVYP FEDDVEVSTGDRVAPGDVLADGGKVKSDVYGRVEVDLVRN VVRVVESYDIDARMGAEAIQQLLKELDLEALEKELLEEMK HPSRARRAKARKRLEVVRAFLDSGNRPEWMILEAVPVLPP DLRPMVQVDGGRFATSDLNDLYRRLINRNNRLKKLLAQGA PEIIIRNEKRMLQEAVDALLDNGRRGAPVTNPGSDRPLRS LTDILSGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQC GLPKRMALELFKPFLLKKMEEKGIAPNVKAARRMLERQRD IKDEVWDALEEVIHGKVVLLNRAPTLHRLGIQAFQPVLVE GQSIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARIQ MLSAHNLLSPASGEPLAKPSRDIILGLYYITQVRKEKKGA GLEFATPEEALAAHERGEVALNAPIKVAGRETSVGRLKYV FANPDEALLAVAHGIVDLQDVVTVRYMGKRLETSPGRILF ARIVAEAVEDEKVAWELIQLDVPQEKNSLKDLVYQAFLRL GMEKTARLLDALKYYGFTFSTTSGITIGIDDAVIPEEKKQ YLEEADRKLLQIEQAYEMGFLTDRERYDQILQLWTETTEK VTQAVFKNFEENYPFNPLYVMAQSGARGNPQQIRQLCGLR GLMQKPSGETFEVPVRSSFREGLTVLEYFISSHGARKGGA DTALRTADSGYLTRKLVDVTHEIVVREADCGTTNYISVPL FQPTRSLRLRKRADIEAGLYGRVLAREVEVLGVRLEEGRY LSMDDVHLLIKAAEAGEIQEVPVRSPLTCQTRYGVCQKCY GYDLSMARPVSIGEAVGIVAAQSIGEPGTQLTMRQGLPRV IELFEARRPKAKAVISEIDGVVRIEETEEKLSVFVESEGF SKEYKLPKEARLLVKDGDYVEAGQPLTRGAIDPHQLLEAK GPEAVERYLVEEIQKVYRAQGVKLHDKHIEIVVRQMMKYV EVTDPGDSRLLEGQVLEKWDVEALNERLIAEGKTPVAWKP LLMGVTKSALSTKSWLSAASFQNTTHVLTEAAIAGKKDEL IGLKENVILGRLIPAGTGSDFVRFTQVVDQKTLKAIEEA Description Functional site 1) chain D residue 1112 type sequence C description BINDING SITE FOR RESIDUE ZN D 2001 source : AC1 2) chain D residue 1194 type sequence C description BINDING SITE FOR RESIDUE ZN D 2001 source : AC1 3) chain D residue 1201 type sequence C description BINDING SITE FOR RESIDUE ZN D 2001 source : AC1 4) chain D residue 1204 type sequence C description BINDING SITE FOR RESIDUE ZN D 2001 source : AC1 5) chain D residue 58 type sequence C description BINDING SITE FOR RESIDUE ZN D 2002 source : AC2 6) chain D residue 60 type sequence C description BINDING SITE FOR RESIDUE ZN D 2002 source : AC2 7) chain D residue 73 type sequence C description BINDING SITE FOR RESIDUE ZN D 2002 source : AC2 8) chain D residue 76 type sequence C description BINDING SITE FOR RESIDUE ZN D 2002 source : AC2 9) chain D residue 739 type sequence D description BINDING SITE FOR RESIDUE MG D 2003 source : AC3 10) chain D residue 741 type sequence D description BINDING SITE FOR RESIDUE MG D 2003 source : AC3 11) chain D residue 743 type sequence D description BINDING SITE FOR RESIDUE MG D 2003 source : AC3 12) chain D residue 739 type sequence D description BINDING SITE FOR RESIDUE MG D 2004 source : AC4 13) chain D residue 704 type sequence R description BINDING SITE FOR RESIDUE ATP D 2005 source : AC5 14) chain D residue 741 type sequence D description BINDING SITE FOR RESIDUE ATP D 2005 source : AC5 15) chain D residue 743 type sequence D description BINDING SITE FOR RESIDUE ATP D 2005 source : AC5 16) chain D residue 704 type sequence R description BINDING SITE FOR RESIDUE 2TM D 2006 source : AC6 17) chain D residue 706 type sequence P description BINDING SITE FOR RESIDUE 2TM D 2006 source : AC6 18) chain D residue 737 type sequence N description BINDING SITE FOR RESIDUE 2TM D 2006 source : AC6 19) chain D residue 739 type sequence D description BINDING SITE FOR RESIDUE 2TM D 2006 source : AC6 20) chain D residue 1029 type sequence R description BINDING SITE FOR RESIDUE 2TM D 2006 source : AC6 21) chain D residue 1201 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 22) chain D residue 1204 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 23) chain D residue 739 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 24) chain D residue 741 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 25) chain D residue 743 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 26) chain D residue 1112 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 27) chain D residue 1194 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 28) chain D residue 76 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 29) chain D residue 58 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 30) chain D residue 60 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1 31) chain D residue 73 type BINDING sequence C description BINDING => ECO:0000255|HAMAP-Rule:MF_01322 source Swiss-Prot : SWS_FT_FI1

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