eF-site ID 4oio-C PDB Code 4oio Chain C click to enlarge Title Crystal structure of Thermus thermophilus pre-insertion substrate complex for de novo transcription initiation Classification TRANSCRIPTION, TRANSFERASE Compound DNA-directed RNA polymerase subunit alpha Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence C:  MEIKRFGRIREVIPLPPLTEIQVESYRRALQADVPPEKRE NVGIQAAFRETFPIEELVLDFLEYRLGEPPFPQDECREKD LTYQAPLYARLQLIHKDTGLIKEDEVFLGHIPLMTEDGSF IINGADRVIVSQIHRSPGVYFTPDPARPGRYIASIIPLPK RGPWIDLEVEPNGVVSMKVNKRKFPLVLLLRVLGYDQETL ARELGAYGELVQGLMDESVFAMRPEEALIRLFTLLRPGDP PKRDKAVAYVYGLIADPRRYDLGEAGRYKAEEKLGIRLSG RTLARFEDGEFKDEVFLPTLRYLFALTAGVPGHEVDDIDH LGNRRIRTVGELMTDQFRVGLARLARGVRERMLMGSEDSL TPAKLVNSRPLEAAIREFFSRSQLSQFKDETNPLSSLRHK RRISALGPGGLTRERAGFDVRDVHRTHYGRICPVETPEGA NIGLITSLAAYARVDELGFIRTPYRRVVGGVVTDEVVYMT ATEEDRYTIAQANTPLEGNRIAAERVVARRKGEPVIVSPE EVEFMDVSPKQVFSVNTNLIPFLEHDDANRALMGSNMQTQ AVPLIRAQAPVVMTGLEERVVRDSLAALYAEEDGEVAKVD GNRIVVRYEDGRLVEYPLRRFYRSNQGTALDQRPRVVVGQ RVRKGDLLADGPASENGFLALGQNVLVAIMPFDGYNFEDA IVISEELLKRDFYTSIHIERYEIEARDTKLGPERITRDIP HLSEAALRDLDEEGVVRIGAEVKPGDILVGRTSFKGESEP TPEERLLRSIFGEKARDVKDTSLRVPPGEGGIVVRTVRLR RGDPGVELKPGVREVVRVYVAQKRKLQVGDKLANRHGNKG VVAKILPVEDMPHLPDGTPVDVILNPLGVPSRMNLGQILE THLGLAGYFLGQRYISPIFDGAKEPEIKELLAQAFEVYFG KRKGEGFGVDKREVEVLRRAEKLGLVTPGKTPEEQLKELF LQGKVVLYDGRTGEPIEGPIVVGQMFIMKLYHMVEDKMHA RSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAH TLQEMLTLKSDDIEGRNAAYEAIIKGEDVPEPSVPESFRV LVKELQALALDVQTLDEKDNPVDIFEGLASK Description Functional site 1) chain C residue 685 type sequence E description BINDING SITE FOR RESIDUE MG D 2004 source : AC4 2) chain C residue 567 type sequence Q description BINDING SITE FOR RESIDUE ATP D 2005 source : AC5 3) chain C residue 838 type sequence K description BINDING SITE FOR RESIDUE ATP D 2005 source : AC5 4) chain C residue 846 type sequence K description BINDING SITE FOR RESIDUE ATP D 2005 source : AC5 5) chain C residue 998 type sequence Y description BINDING SITE FOR RESIDUE ATP D 2005 source : AC5 6) chain C residue 999 type sequence H description BINDING SITE FOR RESIDUE ATP D 2005 source : AC5 7) chain C residue 879 type sequence R description BINDING SITE FOR RESIDUE 2TM D 2006 source : AC6 8) chain C residue 836-848 type prosite sequence GDKLANRHGNKGV description RNA_POL_BETA RNA polymerases beta chain signature. GdKLANrHGNKGV source prosite : PS01166

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