eF-site ID 4oas-ACE PDB Code 4oas Chain A, C, E click to enlarge Title co-crystal structure of MDM2 (17-111) in complex with compound 25 Classification ligase/ligase inhibitor Compound E3 ubiquitin-protein ligase Mdm2 Source Homo sapiens (Human) (MDM2_HUMAN) Sequence A:  QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYL GQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHR KIYTMIYRNLVVV C:  IPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLG QYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRK IYTMIYRNLVVV E:  QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYL GQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHR KIYTMIYRNLVVV Description Functional site 1) chain A residue 54 type sequence L description BINDING SITE FOR RESIDUE 2SW A 201 source : AC1 2) chain A residue 58 type sequence G description BINDING SITE FOR RESIDUE 2SW A 201 source : AC1 3) chain A residue 59 type sequence Q description BINDING SITE FOR RESIDUE 2SW A 201 source : AC1 4) chain A residue 61 type sequence I description BINDING SITE FOR RESIDUE 2SW A 201 source : AC1 5) chain A residue 93 type sequence V description BINDING SITE FOR RESIDUE 2SW A 201 source : AC1 6) chain A residue 94 type sequence K description BINDING SITE FOR RESIDUE 2SW A 201 source : AC1 7) chain A residue 96 type sequence H description BINDING SITE FOR RESIDUE 2SW A 201 source : AC1 8) chain A residue 99 type sequence I description BINDING SITE FOR RESIDUE 2SW A 201 source : AC1 9) chain A residue 100 type sequence Y description BINDING SITE FOR RESIDUE 2SW A 201 source : AC1 10) chain E residue 97 type sequence R description BINDING SITE FOR RESIDUE 2SW A 201 source : AC1 11) chain A residue 97 type sequence R description BINDING SITE FOR RESIDUE 2SW C 201 source : AC2 12) chain C residue 54 type sequence L description BINDING SITE FOR RESIDUE 2SW C 201 source : AC2 13) chain C residue 58 type sequence G description BINDING SITE FOR RESIDUE 2SW C 201 source : AC2 14) chain C residue 59 type sequence Q description BINDING SITE FOR RESIDUE 2SW C 201 source : AC2 15) chain C residue 61 type sequence I description BINDING SITE FOR RESIDUE 2SW C 201 source : AC2 16) chain C residue 93 type sequence V description BINDING SITE FOR RESIDUE 2SW C 201 source : AC2 17) chain C residue 94 type sequence K description BINDING SITE FOR RESIDUE 2SW C 201 source : AC2 18) chain C residue 96 type sequence H description BINDING SITE FOR RESIDUE 2SW C 201 source : AC2 19) chain C residue 99 type sequence I description BINDING SITE FOR RESIDUE 2SW C 201 source : AC2 20) chain E residue 54 type sequence L description BINDING SITE FOR RESIDUE 2SW E 201 source : AC3 21) chain E residue 59 type sequence Q description BINDING SITE FOR RESIDUE 2SW E 201 source : AC3 22) chain E residue 61 type sequence I description BINDING SITE FOR RESIDUE 2SW E 201 source : AC3 23) chain E residue 62 type sequence M description BINDING SITE FOR RESIDUE 2SW E 201 source : AC3 24) chain E residue 93 type sequence V description BINDING SITE FOR RESIDUE 2SW E 201 source : AC3 25) chain E residue 94 type sequence K description BINDING SITE FOR RESIDUE 2SW E 201 source : AC3 26) chain E residue 96 type sequence H description BINDING SITE FOR RESIDUE 2SW E 201 source : AC3 27) chain E residue 100 type sequence Y description BINDING SITE FOR RESIDUE 2SW E 201 source : AC3 28) chain A residue 20 type sequence P description BINDING SITE FOR RESIDUE SO4 E 202 source : AC4 29) chain A residue 21 type sequence A description BINDING SITE FOR RESIDUE SO4 E 202 source : AC4 30) chain C residue 51 type sequence K description BINDING SITE FOR RESIDUE SO4 E 202 source : AC4 31) chain E residue 51 type sequence K description BINDING SITE FOR RESIDUE SO4 E 202 source : AC4

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