eF-site ID 4o8f-AB
PDB Code 4o8f
Chain A, B

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Title Crystal Structure of the complex between PPARgamma mutant R357A and rosiglitazone
Classification TRANSCRIPTION/TRANSCRIPTION inhibitor
Compound Peroxisome proliferator-activated receptor gamma
Source (PPARG_HUMAN)
Sequence A:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTSPFVI
YDMNSLMMGEDTPLEVAIRIFQGCQFRSVEAVQEITEYAK
SIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLI
SEGQGFMTREFLKSLAKPFGDFMEPKFEFAVKFNALELDD
SDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQL
KLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTEL
HPLLQEIYKDLY
B:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSP
FVIYDMNSLMMGEDKIEVAIRIFQGCQFRSVEAVQEITEY
AKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGV
LISEGQGFMTREFLKSLAKPFGDFMEPKFEFAVKFNALEL
DDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALEL
QLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIHPL
LQEIYKDLY
Description


Functional site

1) chain A
residue 282
type
sequence F
description BINDING SITE FOR RESIDUE BRL A 501
source : AC1

2) chain A
residue 285
type
sequence C
description BINDING SITE FOR RESIDUE BRL A 501
source : AC1

3) chain A
residue 288
type
sequence R
description BINDING SITE FOR RESIDUE BRL A 501
source : AC1

4) chain A
residue 289
type
sequence S
description BINDING SITE FOR RESIDUE BRL A 501
source : AC1

5) chain A
residue 323
type
sequence H
description BINDING SITE FOR RESIDUE BRL A 501
source : AC1

6) chain A
residue 339
type
sequence V
description BINDING SITE FOR RESIDUE BRL A 501
source : AC1

7) chain A
residue 341
type
sequence I
description BINDING SITE FOR RESIDUE BRL A 501
source : AC1

8) chain A
residue 353
type
sequence L
description BINDING SITE FOR RESIDUE BRL A 501
source : AC1

9) chain A
residue 449
type
sequence H
description BINDING SITE FOR RESIDUE BRL A 501
source : AC1

10) chain A
residue 473
type
sequence Y
description BINDING SITE FOR RESIDUE BRL A 501
source : AC1

11) chain B
residue 281
type
sequence I
description BINDING SITE FOR RESIDUE BRL B 501
source : AC2

12) chain B
residue 282
type
sequence F
description BINDING SITE FOR RESIDUE BRL B 501
source : AC2

13) chain B
residue 284
type
sequence G
description BINDING SITE FOR RESIDUE BRL B 501
source : AC2

14) chain B
residue 285
type
sequence C
description BINDING SITE FOR RESIDUE BRL B 501
source : AC2

15) chain B
residue 289
type
sequence S
description BINDING SITE FOR RESIDUE BRL B 501
source : AC2

16) chain B
residue 323
type
sequence H
description BINDING SITE FOR RESIDUE BRL B 501
source : AC2

17) chain B
residue 330
type
sequence L
description BINDING SITE FOR RESIDUE BRL B 501
source : AC2

18) chain B
residue 339
type
sequence V
description BINDING SITE FOR RESIDUE BRL B 501
source : AC2

19) chain B
residue 341
type
sequence I
description BINDING SITE FOR RESIDUE BRL B 501
source : AC2

20) chain B
residue 348
type
sequence M
description BINDING SITE FOR RESIDUE BRL B 501
source : AC2

21) chain B
residue 363
type
sequence F
description BINDING SITE FOR RESIDUE BRL B 501
source : AC2

22) chain B
residue 364
type
sequence M
description BINDING SITE FOR RESIDUE BRL B 501
source : AC2

23) chain B
residue 449
type
sequence H
description BINDING SITE FOR RESIDUE BRL B 501
source : AC2

24) chain B
residue 453
type
sequence L
description BINDING SITE FOR RESIDUE BRL B 501
source : AC2

25) chain B
residue 469
type
sequence L
description BINDING SITE FOR RESIDUE BRL B 501
source : AC2

26) chain B
residue 473
type
sequence Y
description BINDING SITE FOR RESIDUE BRL B 501
source : AC2

27) chain A
residue 286
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
source Swiss-Prot : SWS_FT_FI1

28) chain A
residue 323
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
source Swiss-Prot : SWS_FT_FI1

29) chain A
residue 449
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
source Swiss-Prot : SWS_FT_FI1

30) chain A
residue 473
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
source Swiss-Prot : SWS_FT_FI1

31) chain B
residue 286
type BINDING
sequence Q
description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
source Swiss-Prot : SWS_FT_FI1

32) chain B
residue 323
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
source Swiss-Prot : SWS_FT_FI1

33) chain B
residue 449
type BINDING
sequence H
description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
source Swiss-Prot : SWS_FT_FI1

34) chain B
residue 473
type BINDING
sequence Y
description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
source Swiss-Prot : SWS_FT_FI1


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