eF-site ID 4o8f-A PDB Code 4o8f Chain A click to enlarge Title Crystal Structure of the complex between PPARgamma mutant R357A and rosiglitazone Classification TRANSCRIPTION/TRANSCRIPTION inhibitor Compound Peroxisome proliferator-activated receptor gamma Source (PPARG_HUMAN) Sequence A:  ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTSPFVI YDMNSLMMGEDTPLEVAIRIFQGCQFRSVEAVQEITEYAK SIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLI SEGQGFMTREFLKSLAKPFGDFMEPKFEFAVKFNALELDD SDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQL KLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTEL HPLLQEIYKDLY Description Functional site 1) chain A residue 282 type sequence F description BINDING SITE FOR RESIDUE BRL A 501 source : AC1 2) chain A residue 285 type sequence C description BINDING SITE FOR RESIDUE BRL A 501 source : AC1 3) chain A residue 288 type sequence R description BINDING SITE FOR RESIDUE BRL A 501 source : AC1 4) chain A residue 289 type sequence S description BINDING SITE FOR RESIDUE BRL A 501 source : AC1 5) chain A residue 323 type sequence H description BINDING SITE FOR RESIDUE BRL A 501 source : AC1 6) chain A residue 339 type sequence V description BINDING SITE FOR RESIDUE BRL A 501 source : AC1 7) chain A residue 341 type sequence I description BINDING SITE FOR RESIDUE BRL A 501 source : AC1 8) chain A residue 353 type sequence L description BINDING SITE FOR RESIDUE BRL A 501 source : AC1 9) chain A residue 449 type sequence H description BINDING SITE FOR RESIDUE BRL A 501 source : AC1 10) chain A residue 473 type sequence Y description BINDING SITE FOR RESIDUE BRL A 501 source : AC1 11) chain A residue 286 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 12) chain A residue 323 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 13) chain A residue 449 type BINDING sequence H description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 14) chain A residue 473 type BINDING sequence Y description BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG source Swiss-Prot : SWS_FT_FI1 15) chain A residue 224 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links