eF-site ID 4o74-B PDB Code 4o74 Chain B click to enlarge Title Crystal structure of the first bromodomain of human BRD4 in complex with BI 2536 Classification TRANSCRIPTION/INHIBITOR Compound Bromodomain-containing protein 4 Source Homo sapiens (Human) (BRD4_HUMAN) Sequence B:  SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAW PFQQPVDAVKLNLPDYYKIIKTPMDMGTIKKRLENNYYWN AQECIQDFNTMFTNCYIYNKPGDDIVLMAEALEKLFLQKI NELPTEE Description Functional site 1) chain B residue 81 type sequence W description BINDING SITE FOR RESIDUE R78 B 201 source : AC3 2) chain B residue 82 type sequence P description BINDING SITE FOR RESIDUE R78 B 201 source : AC3 3) chain B residue 87 type sequence V description BINDING SITE FOR RESIDUE R78 B 201 source : AC3 4) chain B residue 92 type sequence L description BINDING SITE FOR RESIDUE R78 B 201 source : AC3 5) chain B residue 94 type sequence L description BINDING SITE FOR RESIDUE R78 B 201 source : AC3 6) chain B residue 140 type sequence N description BINDING SITE FOR RESIDUE R78 B 201 source : AC3 7) chain B residue 100 type sequence I description BINDING SITE FOR RESIDUE EDO B 202 source : AC4 8) chain B residue 101 type sequence I description BINDING SITE FOR RESIDUE EDO B 202 source : AC4 9) chain B residue 102 type sequence K description BINDING SITE FOR RESIDUE EDO B 202 source : AC4 10) chain B residue 103 type sequence T description BINDING SITE FOR RESIDUE EDO B 202 source : AC4 11) chain B residue 135 type sequence N description BINDING SITE FOR RESIDUE EDO B 202 source : AC4 12) chain B residue 140 type SITE sequence N description Acetylated histone binding => ECO:0000269|PubMed:22464331 source Swiss-Prot : SWS_FT_FI1 13) chain B residue 99 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI2

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