eF-site ID 4o4l-B PDB Code 4o4l Chain B click to enlarge Title Tubulin-Peloruside A-Epothilone A complex Classification CELL CYCLE/INHIBITOR Compound Tubulin alpha-1B chain Source ORGANISM_COMMON: bovine,cow,domestic cattle,domestic cow; ORGANISM_SCIENTIFIC: Bos taurus; Sequence B:  MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDS DLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGP FGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYP DRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETY CIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ YRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGR MSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTG EGMDEMEFTEAESNMNDLVSEYQQYQDA Description Functional site 1) chain B residue 254 type sequence K description BINDING SITE FOR RESIDUE GTP A 501 source : AC1 2) chain B residue 10 type sequence G description BINDING SITE FOR RESIDUE GDP B 501 source : AC4 3) chain B residue 11 type sequence Q description BINDING SITE FOR RESIDUE GDP B 501 source : AC4 4) chain B residue 12 type sequence C description BINDING SITE FOR RESIDUE GDP B 501 source : AC4 5) chain B residue 15 type sequence Q description BINDING SITE FOR RESIDUE GDP B 501 source : AC4 6) chain B residue 140 type sequence S description BINDING SITE FOR RESIDUE GDP B 501 source : AC4 7) chain B residue 143 type sequence G description BINDING SITE FOR RESIDUE GDP B 501 source : AC4 8) chain B residue 144 type sequence G description BINDING SITE FOR RESIDUE GDP B 501 source : AC4 9) chain B residue 145 type sequence T description BINDING SITE FOR RESIDUE GDP B 501 source : AC4 10) chain B residue 146 type sequence G description BINDING SITE FOR RESIDUE GDP B 501 source : AC4 11) chain B residue 177 type sequence V description BINDING SITE FOR RESIDUE GDP B 501 source : AC4 12) chain B residue 179 type sequence D description BINDING SITE FOR RESIDUE GDP B 501 source : AC4 13) chain B residue 183 type sequence E description BINDING SITE FOR RESIDUE GDP B 501 source : AC4 14) chain B residue 206 type sequence N description BINDING SITE FOR RESIDUE GDP B 501 source : AC4 15) chain B residue 224 type sequence Y description BINDING SITE FOR RESIDUE GDP B 501 source : AC4 16) chain B residue 228 type sequence N description BINDING SITE FOR RESIDUE GDP B 501 source : AC4 17) chain B residue 11 type sequence Q description BINDING SITE FOR RESIDUE MG B 502 source : AC5 18) chain B residue 293 type sequence Q description BINDING SITE FOR RESIDUE POU B 503 source : AC6 19) chain B residue 296 type sequence F description BINDING SITE FOR RESIDUE POU B 503 source : AC6 20) chain B residue 297 type sequence D description BINDING SITE FOR RESIDUE POU B 503 source : AC6 21) chain B residue 298 type sequence S description BINDING SITE FOR RESIDUE POU B 503 source : AC6 22) chain B residue 308 type sequence R description BINDING SITE FOR RESIDUE POU B 503 source : AC6 23) chain B residue 312 type sequence Y description BINDING SITE FOR RESIDUE POU B 503 source : AC6 24) chain B residue 339 type sequence N description BINDING SITE FOR RESIDUE POU B 503 source : AC6 25) chain B residue 342 type sequence Y description BINDING SITE FOR RESIDUE POU B 503 source : AC6 26) chain B residue 217 type sequence L description BINDING SITE FOR RESIDUE EP B 504 source : AC7 27) chain B residue 219 type sequence L description BINDING SITE FOR RESIDUE EP B 504 source : AC7 28) chain B residue 226 type sequence D description BINDING SITE FOR RESIDUE EP B 504 source : AC7 29) chain B residue 229 type sequence H description BINDING SITE FOR RESIDUE EP B 504 source : AC7 30) chain B residue 272 type sequence F description BINDING SITE FOR RESIDUE EP B 504 source : AC7 31) chain B residue 274 type sequence P description BINDING SITE FOR RESIDUE EP B 504 source : AC7 32) chain B residue 275 type sequence L description BINDING SITE FOR RESIDUE EP B 504 source : AC7 33) chain B residue 276 type sequence T description BINDING SITE FOR RESIDUE EP B 504 source : AC7 34) chain B residue 281 type sequence Q description BINDING SITE FOR RESIDUE EP B 504 source : AC7 35) chain B residue 282 type sequence Q description BINDING SITE FOR RESIDUE EP B 504 source : AC7 36) chain B residue 371 type sequence L description BINDING SITE FOR RESIDUE EP B 504 source : AC7 37) chain B residue 113 type sequence E description BINDING SITE FOR RESIDUE CA B 506 source : AC9 38) chain B residue 158 type sequence R description BINDING SITE FOR RESIDUE MES B 507 source : BC1 39) chain B residue 162 type sequence P description BINDING SITE FOR RESIDUE MES B 507 source : BC1 40) chain B residue 163 type sequence D description BINDING SITE FOR RESIDUE MES B 507 source : BC1 41) chain B residue 164 type sequence R description BINDING SITE FOR RESIDUE MES B 507 source : BC1 42) chain B residue 197 type sequence N description BINDING SITE FOR RESIDUE MES B 507 source : BC1 43) chain B residue 199 type sequence D description BINDING SITE FOR RESIDUE MES B 507 source : BC1 44) chain B residue 253 type sequence R description BINDING SITE FOR RESIDUE MES B 507 source : BC1 45) chain B residue 60 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P07437 source Swiss-Prot : SWS_FT_FI10 46) chain B residue 326 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P07437 source Swiss-Prot : SWS_FT_FI11 47) chain B residue 144 type MOD_RES sequence G description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI1 48) chain B residue 145 type MOD_RES sequence T description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI1 49) chain B residue 146 type MOD_RES sequence G description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI1 50) chain B residue 206 type MOD_RES sequence N description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI1 51) chain B residue 228 type MOD_RES sequence N description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI1 52) chain B residue 140 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI1 53) chain B residue 71 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P68363 source Swiss-Prot : SWS_FT_FI2 54) chain B residue 40 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P99024 source Swiss-Prot : SWS_FT_FI3 55) chain B residue 57 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:Q3KRE8 source Swiss-Prot : SWS_FT_FI4 56) chain B residue 60 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P99024 source Swiss-Prot : SWS_FT_FI5 57) chain B residue 174 type MOD_RES sequence S description Phosphoserine; by CDK1 => ECO:0000250|UniProtKB:Q9BVA1 source Swiss-Prot : SWS_FT_FI6 58) chain B residue 292 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:P07437 source Swiss-Prot : SWS_FT_FI7 59) chain B residue 287 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:P07437 source Swiss-Prot : SWS_FT_FI7 60) chain B residue 320 type MOD_RES sequence R description Omega-N-methylarginine => ECO:0000250|UniProtKB:P07437 source Swiss-Prot : SWS_FT_FI8 61) chain B residue 142-148 type prosite sequence GGGTGSG description TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG source prosite : PS00227 62) chain B residue 1-4 type prosite sequence MREI description TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI source prosite : PS00228

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