eF-site ID 4o4i-D
PDB Code 4o4i
Chain D

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Title Tubulin-Laulimalide-Epothilone A complex
Classification CELL CYCLE/INHIBITOR
Compound Tubulin alpha-1B chain
Source ORGANISM_COMMON: bovine,cow,domestic cattle,domestic cow; ORGANISM_SCIENTIFIC: Bos taurus;
Sequence D:  MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDS
DLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGP
FGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYP
DRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETY
CIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ
YRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGR
MSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTG
EGMDEMEFTEAESNMNDLVSEYQQYQDATAD
Description


Functional site

1) chain D
residue 254
type
sequence K
description BINDING SITE FOR RESIDUE GTP C 501
source : BC2

2) chain D
residue 10
type
sequence G
description BINDING SITE FOR RESIDUE GDP D 501
source : BC5

3) chain D
residue 11
type
sequence Q
description BINDING SITE FOR RESIDUE GDP D 501
source : BC5

4) chain D
residue 12
type
sequence C
description BINDING SITE FOR RESIDUE GDP D 501
source : BC5

5) chain D
residue 15
type
sequence Q
description BINDING SITE FOR RESIDUE GDP D 501
source : BC5

6) chain D
residue 140
type
sequence S
description BINDING SITE FOR RESIDUE GDP D 501
source : BC5

7) chain D
residue 143
type
sequence G
description BINDING SITE FOR RESIDUE GDP D 501
source : BC5

8) chain D
residue 144
type
sequence G
description BINDING SITE FOR RESIDUE GDP D 501
source : BC5

9) chain D
residue 145
type
sequence T
description BINDING SITE FOR RESIDUE GDP D 501
source : BC5

10) chain D
residue 146
type
sequence G
description BINDING SITE FOR RESIDUE GDP D 501
source : BC5

11) chain D
residue 178
type
sequence S
description BINDING SITE FOR RESIDUE GDP D 501
source : BC5

12) chain D
residue 183
type
sequence E
description BINDING SITE FOR RESIDUE GDP D 501
source : BC5

13) chain D
residue 206
type
sequence N
description BINDING SITE FOR RESIDUE GDP D 501
source : BC5

14) chain D
residue 224
type
sequence Y
description BINDING SITE FOR RESIDUE GDP D 501
source : BC5

15) chain D
residue 228
type
sequence N
description BINDING SITE FOR RESIDUE GDP D 501
source : BC5

16) chain D
residue 11
type
sequence Q
description BINDING SITE FOR RESIDUE MG D 502
source : BC6

17) chain D
residue 217
type
sequence L
description BINDING SITE FOR RESIDUE EP D 503
source : BC7

18) chain D
residue 226
type
sequence D
description BINDING SITE FOR RESIDUE EP D 503
source : BC7

19) chain D
residue 229
type
sequence H
description BINDING SITE FOR RESIDUE EP D 503
source : BC7

20) chain D
residue 274
type
sequence P
description BINDING SITE FOR RESIDUE EP D 503
source : BC7

21) chain D
residue 275
type
sequence L
description BINDING SITE FOR RESIDUE EP D 503
source : BC7

22) chain D
residue 276
type
sequence T
description BINDING SITE FOR RESIDUE EP D 503
source : BC7

23) chain D
residue 278
type
sequence R
description BINDING SITE FOR RESIDUE EP D 503
source : BC7

24) chain D
residue 281
type
sequence Q
description BINDING SITE FOR RESIDUE EP D 503
source : BC7

25) chain D
residue 144
type MOD_RES
sequence G
description Phosphoserine => ECO:0007744|PubMed:22673903
source Swiss-Prot : SWS_FT_FI1

26) chain D
residue 145
type MOD_RES
sequence T
description Phosphoserine => ECO:0007744|PubMed:22673903
source Swiss-Prot : SWS_FT_FI1

27) chain D
residue 146
type MOD_RES
sequence G
description Phosphoserine => ECO:0007744|PubMed:22673903
source Swiss-Prot : SWS_FT_FI1

28) chain D
residue 206
type MOD_RES
sequence N
description Phosphoserine => ECO:0007744|PubMed:22673903
source Swiss-Prot : SWS_FT_FI1

29) chain D
residue 228
type MOD_RES
sequence N
description Phosphoserine => ECO:0007744|PubMed:22673903
source Swiss-Prot : SWS_FT_FI1

30) chain D
residue 11
type MOD_RES
sequence Q
description Phosphoserine => ECO:0007744|PubMed:22673903
source Swiss-Prot : SWS_FT_FI1

31) chain D
residue 140
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:22673903
source Swiss-Prot : SWS_FT_FI1

32) chain D
residue 60
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P07437
source Swiss-Prot : SWS_FT_FI10

33) chain D
residue 326
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P07437
source Swiss-Prot : SWS_FT_FI11

34) chain D
residue 71
type BINDING
sequence E
description BINDING => ECO:0000250|UniProtKB:P68363
source Swiss-Prot : SWS_FT_FI2

35) chain D
residue 40
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P99024
source Swiss-Prot : SWS_FT_FI3

36) chain D
residue 57
type MOD_RES
sequence T
description Phosphothreonine => ECO:0000250|UniProtKB:Q3KRE8
source Swiss-Prot : SWS_FT_FI4

37) chain D
residue 60
type MOD_RES
sequence K
description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P99024
source Swiss-Prot : SWS_FT_FI5

38) chain D
residue 174
type MOD_RES
sequence S
description Phosphoserine; by CDK1 => ECO:0000250|UniProtKB:Q9BVA1
source Swiss-Prot : SWS_FT_FI6

39) chain D
residue 287
type MOD_RES
sequence T
description Phosphothreonine => ECO:0000250|UniProtKB:P07437
source Swiss-Prot : SWS_FT_FI7

40) chain D
residue 292
type MOD_RES
sequence T
description Phosphothreonine => ECO:0000250|UniProtKB:P07437
source Swiss-Prot : SWS_FT_FI7

41) chain D
residue 320
type MOD_RES
sequence R
description Omega-N-methylarginine => ECO:0000250|UniProtKB:P07437
source Swiss-Prot : SWS_FT_FI8


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