eF-site ID 4o4i-D PDB Code 4o4i Chain D click to enlarge Title Tubulin-Laulimalide-Epothilone A complex Classification CELL CYCLE/INHIBITOR Compound Tubulin alpha-1B chain Source ORGANISM_COMMON: bovine,cow,domestic cattle,domestic cow; ORGANISM_SCIENTIFIC: Bos taurus; Sequence D:  MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDS DLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGP FGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYP DRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETY CIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ YRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGR MSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTG EGMDEMEFTEAESNMNDLVSEYQQYQDATAD Description Functional site 1) chain D residue 254 type sequence K description BINDING SITE FOR RESIDUE GTP C 501 source : BC2 2) chain D residue 10 type sequence G description BINDING SITE FOR RESIDUE GDP D 501 source : BC5 3) chain D residue 11 type sequence Q description BINDING SITE FOR RESIDUE GDP D 501 source : BC5 4) chain D residue 12 type sequence C description BINDING SITE FOR RESIDUE GDP D 501 source : BC5 5) chain D residue 15 type sequence Q description BINDING SITE FOR RESIDUE GDP D 501 source : BC5 6) chain D residue 140 type sequence S description BINDING SITE FOR RESIDUE GDP D 501 source : BC5 7) chain D residue 143 type sequence G description BINDING SITE FOR RESIDUE GDP D 501 source : BC5 8) chain D residue 144 type sequence G description BINDING SITE FOR RESIDUE GDP D 501 source : BC5 9) chain D residue 145 type sequence T description BINDING SITE FOR RESIDUE GDP D 501 source : BC5 10) chain D residue 146 type sequence G description BINDING SITE FOR RESIDUE GDP D 501 source : BC5 11) chain D residue 178 type sequence S description BINDING SITE FOR RESIDUE GDP D 501 source : BC5 12) chain D residue 183 type sequence E description BINDING SITE FOR RESIDUE GDP D 501 source : BC5 13) chain D residue 206 type sequence N description BINDING SITE FOR RESIDUE GDP D 501 source : BC5 14) chain D residue 224 type sequence Y description BINDING SITE FOR RESIDUE GDP D 501 source : BC5 15) chain D residue 228 type sequence N description BINDING SITE FOR RESIDUE GDP D 501 source : BC5 16) chain D residue 11 type sequence Q description BINDING SITE FOR RESIDUE MG D 502 source : BC6 17) chain D residue 217 type sequence L description BINDING SITE FOR RESIDUE EP D 503 source : BC7 18) chain D residue 226 type sequence D description BINDING SITE FOR RESIDUE EP D 503 source : BC7 19) chain D residue 229 type sequence H description BINDING SITE FOR RESIDUE EP D 503 source : BC7 20) chain D residue 274 type sequence P description BINDING SITE FOR RESIDUE EP D 503 source : BC7 21) chain D residue 275 type sequence L description BINDING SITE FOR RESIDUE EP D 503 source : BC7 22) chain D residue 276 type sequence T description BINDING SITE FOR RESIDUE EP D 503 source : BC7 23) chain D residue 278 type sequence R description BINDING SITE FOR RESIDUE EP D 503 source : BC7 24) chain D residue 281 type sequence Q description BINDING SITE FOR RESIDUE EP D 503 source : BC7 25) chain D residue 144 type MOD_RES sequence G description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI1 26) chain D residue 145 type MOD_RES sequence T description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI1 27) chain D residue 146 type MOD_RES sequence G description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI1 28) chain D residue 206 type MOD_RES sequence N description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI1 29) chain D residue 228 type MOD_RES sequence N description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI1 30) chain D residue 11 type MOD_RES sequence Q description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI1 31) chain D residue 140 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:22673903 source Swiss-Prot : SWS_FT_FI1 32) chain D residue 60 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P07437 source Swiss-Prot : SWS_FT_FI10 33) chain D residue 326 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P07437 source Swiss-Prot : SWS_FT_FI11 34) chain D residue 71 type BINDING sequence E description BINDING => ECO:0000250|UniProtKB:P68363 source Swiss-Prot : SWS_FT_FI2 35) chain D residue 40 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P99024 source Swiss-Prot : SWS_FT_FI3 36) chain D residue 57 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:Q3KRE8 source Swiss-Prot : SWS_FT_FI4 37) chain D residue 60 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P99024 source Swiss-Prot : SWS_FT_FI5 38) chain D residue 174 type MOD_RES sequence S description Phosphoserine; by CDK1 => ECO:0000250|UniProtKB:Q9BVA1 source Swiss-Prot : SWS_FT_FI6 39) chain D residue 287 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:P07437 source Swiss-Prot : SWS_FT_FI7 40) chain D residue 292 type MOD_RES sequence T description Phosphothreonine => ECO:0000250|UniProtKB:P07437 source Swiss-Prot : SWS_FT_FI7 41) chain D residue 320 type MOD_RES sequence R description Omega-N-methylarginine => ECO:0000250|UniProtKB:P07437 source Swiss-Prot : SWS_FT_FI8

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