eF-site ID 4o4i-B
PDB Code 4o4i
Chain B

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Title Tubulin-Laulimalide-Epothilone A complex
Classification CELL CYCLE/INHIBITOR
Compound Tubulin alpha-1B chain
Source ORGANISM_COMMON: bovine,cow,domestic cattle,domestic cow; ORGANISM_SCIENTIFIC: Bos taurus;
Sequence B:  MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDS
DLQLERINVYYNEATGNKYVPRAILVDLEPGTMDSVRSGP
FGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVV
RKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYP
DRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETY
CIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCL
RFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ
YRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGR
MSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRG
LKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTG
EGMDEMEFTEAESNMNDLVSEYQQYQDA
Description


Functional site

1) chain B
residue 254
type
sequence K
description BINDING SITE FOR RESIDUE GTP A 501
source : AC1

2) chain B
residue 10
type
sequence G
description BINDING SITE FOR RESIDUE GDP B 501
source : AC4

3) chain B
residue 11
type
sequence Q
description BINDING SITE FOR RESIDUE GDP B 501
source : AC4

4) chain B
residue 12
type
sequence C
description BINDING SITE FOR RESIDUE GDP B 501
source : AC4

5) chain B
residue 15
type
sequence Q
description BINDING SITE FOR RESIDUE GDP B 501
source : AC4

6) chain B
residue 140
type
sequence S
description BINDING SITE FOR RESIDUE GDP B 501
source : AC4

7) chain B
residue 143
type
sequence G
description BINDING SITE FOR RESIDUE GDP B 501
source : AC4

8) chain B
residue 144
type
sequence G
description BINDING SITE FOR RESIDUE GDP B 501
source : AC4

9) chain B
residue 145
type
sequence T
description BINDING SITE FOR RESIDUE GDP B 501
source : AC4

10) chain B
residue 146
type
sequence G
description BINDING SITE FOR RESIDUE GDP B 501
source : AC4

11) chain B
residue 177
type
sequence V
description BINDING SITE FOR RESIDUE GDP B 501
source : AC4

12) chain B
residue 179
type
sequence D
description BINDING SITE FOR RESIDUE GDP B 501
source : AC4

13) chain B
residue 183
type
sequence E
description BINDING SITE FOR RESIDUE GDP B 501
source : AC4

14) chain B
residue 206
type
sequence N
description BINDING SITE FOR RESIDUE GDP B 501
source : AC4

15) chain B
residue 224
type
sequence Y
description BINDING SITE FOR RESIDUE GDP B 501
source : AC4

16) chain B
residue 228
type
sequence N
description BINDING SITE FOR RESIDUE GDP B 501
source : AC4

17) chain B
residue 71
type
sequence E
description BINDING SITE FOR RESIDUE MG B 502
source : AC5

18) chain B
residue 217
type
sequence L
description BINDING SITE FOR RESIDUE EP B 503
source : AC6

19) chain B
residue 219
type
sequence L
description BINDING SITE FOR RESIDUE EP B 503
source : AC6

20) chain B
residue 226
type
sequence D
description BINDING SITE FOR RESIDUE EP B 503
source : AC6

21) chain B
residue 229
type
sequence H
description BINDING SITE FOR RESIDUE EP B 503
source : AC6

22) chain B
residue 233
type
sequence A
description BINDING SITE FOR RESIDUE EP B 503
source : AC6

23) chain B
residue 272
type
sequence F
description BINDING SITE FOR RESIDUE EP B 503
source : AC6

24) chain B
residue 274
type
sequence P
description BINDING SITE FOR RESIDUE EP B 503
source : AC6

25) chain B
residue 275
type
sequence L
description BINDING SITE FOR RESIDUE EP B 503
source : AC6

26) chain B
residue 276
type
sequence T
description BINDING SITE FOR RESIDUE EP B 503
source : AC6

27) chain B
residue 278
type
sequence R
description BINDING SITE FOR RESIDUE EP B 503
source : AC6

28) chain B
residue 281
type
sequence Q
description BINDING SITE FOR RESIDUE EP B 503
source : AC6

29) chain B
residue 282
type
sequence Q
description BINDING SITE FOR RESIDUE EP B 503
source : AC6

30) chain B
residue 284
type
sequence R
description BINDING SITE FOR RESIDUE EP B 503
source : AC6

31) chain B
residue 371
type
sequence L
description BINDING SITE FOR RESIDUE EP B 503
source : AC6

32) chain B
residue 11
type
sequence Q
description BINDING SITE FOR RESIDUE MG B 504
source : AC7

33) chain B
residue 179
type
sequence D
description BINDING SITE FOR RESIDUE MG B 504
source : AC7

34) chain B
residue 293
type
sequence Q
description BINDING SITE FOR RESIDUE LLM B 505
source : AC8

35) chain B
residue 296
type
sequence F
description BINDING SITE FOR RESIDUE LLM B 505
source : AC8

36) chain B
residue 297
type
sequence D
description BINDING SITE FOR RESIDUE LLM B 505
source : AC8

37) chain B
residue 298
type
sequence S
description BINDING SITE FOR RESIDUE LLM B 505
source : AC8

38) chain B
residue 308
type
sequence R
description BINDING SITE FOR RESIDUE LLM B 505
source : AC8

39) chain B
residue 334
type
sequence N
description BINDING SITE FOR RESIDUE LLM B 505
source : AC8

40) chain B
residue 339
type
sequence N
description BINDING SITE FOR RESIDUE LLM B 505
source : AC8

41) chain B
residue 113
type
sequence E
description BINDING SITE FOR RESIDUE CA B 506
source : AC9

42) chain B
residue 158
type
sequence R
description BINDING SITE FOR RESIDUE MES B 507
source : BC1

43) chain B
residue 162
type
sequence P
description BINDING SITE FOR RESIDUE MES B 507
source : BC1

44) chain B
residue 163
type
sequence D
description BINDING SITE FOR RESIDUE MES B 507
source : BC1

45) chain B
residue 164
type
sequence R
description BINDING SITE FOR RESIDUE MES B 507
source : BC1

46) chain B
residue 197
type
sequence N
description BINDING SITE FOR RESIDUE MES B 507
source : BC1

47) chain B
residue 198
type
sequence T
description BINDING SITE FOR RESIDUE MES B 507
source : BC1

48) chain B
residue 199
type
sequence D
description BINDING SITE FOR RESIDUE MES B 507
source : BC1

49) chain B
residue 253
type
sequence R
description BINDING SITE FOR RESIDUE MES B 507
source : BC1

50) chain B
residue 320
type MOD_RES
sequence R
description Omega-N-methylarginine => ECO:0000250|UniProtKB:P07437
source Swiss-Prot : SWS_FT_FI8

51) chain B
residue 140
type MOD_RES
sequence S
description Phosphoserine => ECO:0007744|PubMed:22673903
source Swiss-Prot : SWS_FT_FI1

52) chain B
residue 144
type MOD_RES
sequence G
description Phosphoserine => ECO:0007744|PubMed:22673903
source Swiss-Prot : SWS_FT_FI1

53) chain B
residue 145
type MOD_RES
sequence T
description Phosphoserine => ECO:0007744|PubMed:22673903
source Swiss-Prot : SWS_FT_FI1

54) chain B
residue 146
type MOD_RES
sequence G
description Phosphoserine => ECO:0007744|PubMed:22673903
source Swiss-Prot : SWS_FT_FI1

55) chain B
residue 206
type MOD_RES
sequence N
description Phosphoserine => ECO:0007744|PubMed:22673903
source Swiss-Prot : SWS_FT_FI1

56) chain B
residue 228
type MOD_RES
sequence N
description Phosphoserine => ECO:0007744|PubMed:22673903
source Swiss-Prot : SWS_FT_FI1

57) chain B
residue 71
type BINDING
sequence E
description BINDING => ECO:0000250|UniProtKB:P68363
source Swiss-Prot : SWS_FT_FI2

58) chain B
residue 40
type MOD_RES
sequence S
description Phosphoserine => ECO:0000250|UniProtKB:P99024
source Swiss-Prot : SWS_FT_FI3

59) chain B
residue 142-148
type prosite
sequence GGGTGSG
description TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG
source prosite : PS00227

60) chain B
residue 1-4
type prosite
sequence MREI
description TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI
source prosite : PS00228

61) chain B
residue 60
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate => ECO:0000250|UniProtKB:P07437
source Swiss-Prot : SWS_FT_FI10

62) chain B
residue 326
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P07437
source Swiss-Prot : SWS_FT_FI11

63) chain B
residue 57
type MOD_RES
sequence T
description Phosphothreonine => ECO:0000250|UniProtKB:Q3KRE8
source Swiss-Prot : SWS_FT_FI4

64) chain B
residue 60
type MOD_RES
sequence K
description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P99024
source Swiss-Prot : SWS_FT_FI5

65) chain B
residue 174
type MOD_RES
sequence S
description Phosphoserine; by CDK1 => ECO:0000250|UniProtKB:Q9BVA1
source Swiss-Prot : SWS_FT_FI6

66) chain B
residue 287
type MOD_RES
sequence T
description Phosphothreonine => ECO:0000250|UniProtKB:P07437
source Swiss-Prot : SWS_FT_FI7

67) chain B
residue 292
type MOD_RES
sequence T
description Phosphothreonine => ECO:0000250|UniProtKB:P07437
source Swiss-Prot : SWS_FT_FI7


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