eF-site ID 4o43-B PDB Code 4o43 Chain B click to enlarge Title DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities Classification DNA BINDING PROTEIN/inhibitor Compound Exonuclease, putative Source (Q9X1X0_THEMA) Sequence B:  LKELKILHTSDWHLGVTSWTSSRPVDRREELKKALDKVVE EAEKREVDLILLTGDLLHSRNNPSVVALHDLLDYLKRMMR TAPVVVLPGNHDWKGLKLFGNFVTSISSDITFVMSFEPVD VEAKRGQKVRILPFPYPDESEALRKNEGDFRFFLESRLNK LYEEALKKEDFAIFMGHFTVEGLAGYAGIEQGREIIINRA LIPSVVDYAALGHIHSFREIQKQPLTIYPGSLIRIDFGEE ADEKGAVFVELKRGEPPRYERIDASPLPLKTLYYKKIDTS ALKSIRDFCRNFPGYVRVVYEEDSGILPDLMGEIDNLVKI E Description Functional site 1) chain B residue 102 type sequence F description BINDING SITE FOR RESIDUE 2PW A 403 source : AC3 2) chain B residue 66 type sequence P description BINDING SITE FOR RESIDUE 2PW A 404 source : AC4 3) chain B residue 75 type sequence L description BINDING SITE FOR RESIDUE 2PW A 404 source : AC4 4) chain B residue 94 type sequence H description BINDING SITE FOR RESIDUE 2PW A 404 source : AC4 5) chain B residue 99 type sequence L description BINDING SITE FOR RESIDUE 2PW A 404 source : AC4 6) chain B residue 115 type sequence F description BINDING SITE FOR RESIDUE 2PW A 404 source : AC4 7) chain B residue 58 type sequence D description BINDING SITE FOR RESIDUE MN B 401 source : AC5 8) chain B residue 180 type sequence H description BINDING SITE FOR RESIDUE MN B 401 source : AC5 9) chain B residue 216 type sequence H description BINDING SITE FOR RESIDUE MN B 401 source : AC5 10) chain B residue 14 type sequence D description BINDING SITE FOR RESIDUE MN B 402 source : AC6 11) chain B residue 16 type sequence H description BINDING SITE FOR RESIDUE MN B 402 source : AC6 12) chain B residue 216 type sequence H description BINDING SITE FOR RESIDUE MN B 402 source : AC6 13) chain B residue 218 type sequence H description BINDING SITE FOR RESIDUE MN B 402 source : AC6 14) chain B residue 94 type ACT_SITE sequence H description Proton donor => ECO:0000250|UniProtKB:Q8U1N9, ECO:0000255|HAMAP-Rule:MF_02044 source Swiss-Prot : SWS_FT_FI1 15) chain B residue 14 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21937514, ECO:0000269|PubMed:24316220, ECO:0007744|PDB:3THN, ECO:0007744|PDB:3THO, ECO:0007744|PDB:4NZV, ECO:0007744|PDB:4O24, ECO:0007744|PDB:4O43, ECO:0007744|PDB:4O4K, ECO:0007744|PDB:4O5G source Swiss-Prot : SWS_FT_FI2 16) chain B residue 16 type BINDING sequence H description BINDING => ECO:0000269|PubMed:21937514, ECO:0000269|PubMed:24316220, ECO:0007744|PDB:3THN, ECO:0007744|PDB:3THO, ECO:0007744|PDB:4NZV, ECO:0007744|PDB:4O24, ECO:0007744|PDB:4O43, ECO:0007744|PDB:4O4K, ECO:0007744|PDB:4O5G source Swiss-Prot : SWS_FT_FI2 17) chain B residue 58 type BINDING sequence D description BINDING => ECO:0000269|PubMed:21937514, ECO:0000269|PubMed:24316220, ECO:0007744|PDB:3THN, ECO:0007744|PDB:3THO, ECO:0007744|PDB:4NZV, ECO:0007744|PDB:4O24, ECO:0007744|PDB:4O43, ECO:0007744|PDB:4O4K, ECO:0007744|PDB:4O5G source Swiss-Prot : SWS_FT_FI2 18) chain B residue 216 type BINDING sequence H description BINDING => ECO:0000269|PubMed:21937514, ECO:0000269|PubMed:24316220, ECO:0007744|PDB:3THN, ECO:0007744|PDB:3THO, ECO:0007744|PDB:4NZV, ECO:0007744|PDB:4O24, ECO:0007744|PDB:4O43, ECO:0007744|PDB:4O4K, ECO:0007744|PDB:4O5G source Swiss-Prot : SWS_FT_FI2 19) chain B residue 180 type BINDING sequence H description BINDING => ECO:0000269|PubMed:21937514, ECO:0000269|PubMed:24316220, ECO:0007744|PDB:3THN, ECO:0007744|PDB:3THO, ECO:0007744|PDB:4NZV, ECO:0007744|PDB:4O24, ECO:0007744|PDB:4O4K source Swiss-Prot : SWS_FT_FI3 20) chain B residue 218 type BINDING sequence H description BINDING => ECO:0000269|PubMed:21937514, ECO:0000269|PubMed:24316220, ECO:0007744|PDB:4NZV source Swiss-Prot : SWS_FT_FI4

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