eF-site ID 4o43-AB PDB Code 4o43 Chain A, B click to enlarge Title DNA Double-Strand Break Repair Pathway Choice Is Directed by Distinct MRE11 Nuclease Activities Classification DNA BINDING PROTEIN/inhibitor Compound Exonuclease, putative Source (Q9X1X0_THEMA) Sequence A:  IHHHHHHVINLKELKILHTSDWHLGVTSWTSSRPVDRREE LKKALDKVVEEAEKREVDLILLTGDLLHSRNNPSVVALHD LLDYLKRMMRTAPVVVLPGNHDWKGLKLFGNFVTSISSDI TFVMSFEPVDVEAKRGQKVRILPFPYPDESEALRKNEGDF RFFLESRLNKLYEEALKKEDFAIFMGHFTVEGLAGYAGIE QGREIIINRALIPSVVDYAALGHIHSFREIQKQPLTIYPG SLIRIDFGEEADEKGAVFVELKRGEPPRYERIDASPLPLK TLYYKKIDTSALKSIRDFCRNFPGYVRVVYEEDSGILPDL MGEIDNLVKIE B:  LKELKILHTSDWHLGVTSWTSSRPVDRREELKKALDKVVE EAEKREVDLILLTGDLLHSRNNPSVVALHDLLDYLKRMMR TAPVVVLPGNHDWKGLKLFGNFVTSISSDITFVMSFEPVD VEAKRGQKVRILPFPYPDESEALRKNEGDFRFFLESRLNK LYEEALKKEDFAIFMGHFTVEGLAGYAGIEQGREIIINRA LIPSVVDYAALGHIHSFREIQKQPLTIYPGSLIRIDFGEE ADEKGAVFVELKRGEPPRYERIDASPLPLKTLYYKKIDTS ALKSIRDFCRNFPGYVRVVYEEDSGILPDLMGEIDNLVKI E Description Functional site 1) chain A residue 58 type sequence D description BINDING SITE FOR RESIDUE MN A 401 source : AC1 2) chain A residue 180 type sequence H description BINDING SITE FOR RESIDUE MN A 401 source : AC1 3) chain A residue 216 type sequence H description BINDING SITE FOR RESIDUE MN A 401 source : AC1 4) chain A residue 14 type sequence D description BINDING SITE FOR RESIDUE MN A 402 source : AC2 5) chain A residue 16 type sequence H description BINDING SITE FOR RESIDUE MN A 402 source : AC2 6) chain A residue 216 type sequence H description BINDING SITE FOR RESIDUE MN A 402 source : AC2 7) chain A residue 218 type sequence H description BINDING SITE FOR RESIDUE MN A 402 source : AC2 8) chain A residue 60 type sequence L description BINDING SITE FOR RESIDUE 2PW A 403 source : AC3 9) chain A residue 66 type sequence P description BINDING SITE FOR RESIDUE 2PW A 403 source : AC3 10) chain A residue 75 type sequence L description BINDING SITE FOR RESIDUE 2PW A 403 source : AC3 11) chain A residue 99 type sequence L description BINDING SITE FOR RESIDUE 2PW A 403 source : AC3 12) chain A residue 115 type sequence F description BINDING SITE FOR RESIDUE 2PW A 403 source : AC3 13) chain B residue 102 type sequence F description BINDING SITE FOR RESIDUE 2PW A 403 source : AC3 14) chain A residue 102 type sequence F description BINDING SITE FOR RESIDUE 2PW A 404 source : AC4 15) chain B residue 66 type sequence P description BINDING SITE FOR RESIDUE 2PW A 404 source : AC4 16) chain B residue 75 type sequence L description BINDING SITE FOR RESIDUE 2PW A 404 source : AC4 17) chain B residue 94 type sequence H description BINDING SITE FOR RESIDUE 2PW A 404 source : AC4 18) chain B residue 99 type sequence L description BINDING SITE FOR RESIDUE 2PW A 404 source : AC4 19) chain B residue 115 type sequence F description BINDING SITE FOR RESIDUE 2PW A 404 source : AC4 20) chain B residue 58 type sequence D description BINDING SITE FOR RESIDUE MN B 401 source : AC5 21) chain B residue 180 type sequence H description BINDING SITE FOR RESIDUE MN B 401 source : AC5 22) chain B residue 216 type sequence H description BINDING SITE FOR RESIDUE MN B 401 source : AC5 23) chain B residue 14 type sequence D description BINDING SITE FOR RESIDUE MN B 402 source : AC6 24) chain B residue 16 type sequence H description BINDING SITE FOR RESIDUE MN B 402 source : AC6 25) chain B residue 216 type sequence H description BINDING SITE FOR RESIDUE MN B 402 source : AC6 26) chain B residue 218 type sequence H description BINDING SITE FOR RESIDUE MN B 402 source : AC6

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