|
|
eF-site ID
|
4o0t-B |
|
PDB Code
|
4o0t |
|
Chain
|
B |
|
click to enlarge
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Title
|
Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors |
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Classification
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transferase/transferase inhibitor |
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Compound
|
Serine/threonine-protein kinase PAK 1 |
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Source
|
Homo sapiens (Human) (PAK1_HUMAN) |
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Sequence
|
B: |
EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQ
EVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY
LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECL
QALEFLHSNQVIHRNIKSDNILLGMDGSVKLTDFEQSKRS
EMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEP
PYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCL
EMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK
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Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
389 |
| type |
ACT_SITE |
| sequence |
N
|
| description |
Proton acceptor => ECO:0000269|PubMed:22153498
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
B |
| residue |
276 |
| type |
BINDING |
| sequence |
I
|
| description |
BINDING => ECO:0000269|PubMed:22153498
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
3)
|
chain |
B |
| residue |
299 |
| type |
BINDING |
| sequence |
K
|
| description |
BINDING => ECO:0000269|PubMed:22153498
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
4)
|
chain |
B |
| residue |
345 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000269|PubMed:22153498
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
5)
|
chain |
B |
| residue |
285 |
| type |
MOD_RES |
| sequence |
Y
|
| description |
Phosphotyrosine; by JAK2 => ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
6)
|
chain |
B |
| residue |
423 |
| type |
MOD_RES |
| sequence |
E
|
| description |
Phosphothreonine; by autocatalysis, BRSK2 and PDPK1 => ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:22153498, ECO:0000269|PubMed:22669945
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|