eF-site ID 4o0t-B
PDB Code 4o0t
Chain B

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Title Back pocket flexibility provides group-II PAK selectivity for type 1 kinase inhibitors
Classification transferase/transferase inhibitor
Compound Serine/threonine-protein kinase PAK 1
Source Homo sapiens (Human) (PAK1_HUMAN)
Sequence B:  EKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQ
EVAIKQMNLQQQPKKELIINEILVMRENKNPNIVNYLDSY
LVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECL
QALEFLHSNQVIHRNIKSDNILLGMDGSVKLTDFEQSKRS
EMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEP
PYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCL
EMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK
Description


Functional site

1) chain B
residue 389
type ACT_SITE
sequence N
description Proton acceptor => ECO:0000269|PubMed:22153498
source Swiss-Prot : SWS_FT_FI1

2) chain B
residue 276
type BINDING
sequence I
description BINDING => ECO:0000269|PubMed:22153498
source Swiss-Prot : SWS_FT_FI2

3) chain B
residue 299
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:22153498
source Swiss-Prot : SWS_FT_FI2

4) chain B
residue 345
type BINDING
sequence E
description BINDING => ECO:0000269|PubMed:22153498
source Swiss-Prot : SWS_FT_FI2

5) chain B
residue 285
type MOD_RES
sequence Y
description Phosphotyrosine; by JAK2 => ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089
source Swiss-Prot : SWS_FT_FI3

6) chain B
residue 423
type MOD_RES
sequence E
description Phosphothreonine; by autocatalysis, BRSK2 and PDPK1 => ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:22153498, ECO:0000269|PubMed:22669945
source Swiss-Prot : SWS_FT_FI4


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