eF-site ID 4nym-S PDB Code 4nym Chain S click to enlarge Title Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange Classification SIGNALING PROTEIN Compound GTPase HRas Source null (SOS1_HUMAN) Sequence S:  QMRLPSADVYRFAEPDSEENIIFEEGIPIIKAGTVIKLIE RLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIP EPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLN VCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVE SITKIIQRKKIAHNITFQSSPPTVEWHISRPGHIETFDLL TLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEIN SPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIE ILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQ KKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNI LKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQ PYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIE PRNPKPLPRFPKKYSYPLKSPGVRPSNPR Description Functional site 1) chain S residue 878 type sequence M description BINDING SITE FOR RESIDUE RND S 1101 source : AC3 2) chain S residue 879 type sequence N description BINDING SITE FOR RESIDUE RND S 1101 source : AC3 3) chain S residue 884 type sequence Y description BINDING SITE FOR RESIDUE RND S 1101 source : AC3 4) chain S residue 887 type sequence D description BINDING SITE FOR RESIDUE RND S 1101 source : AC3 5) chain S residue 890 type sequence F description BINDING SITE FOR RESIDUE RND S 1101 source : AC3 6) chain S residue 898 type sequence K description BINDING SITE FOR RESIDUE RND S 1101 source : AC3 7) chain S residue 902 type sequence E description BINDING SITE FOR RESIDUE RND S 1101 source : AC3 8) chain S residue 905 type sequence H description BINDING SITE FOR RESIDUE RND S 1101 source : AC3 9) chain S residue 927-960 type prosite sequence VPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK description RASGEF Ras Guanine-nucleotide exchange factors domain signature. VPFfGiyLtNIlkteegnpevlkrhgkel.................INFsK source prosite : PS00720

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