eF-site ID 4nyj-Q PDB Code 4nyj Chain Q click to enlarge Title Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange Classification SIGNALING PROTEIN Compound GTPase HRas Source Homo sapiens (Human) (SOS1_HUMAN) Sequence Q:  MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSY RKQVVIDGETCLLDILDTAGQEEASAMRDQYMRTGEGFLC VFAINNTKSFEDIHQYREQIKRVKDSDDVPMVLVGNKCDL AARTVESRQAQDLARSYGIPYIETSAKTRQGVEDAFYTLV REIRQH Description Functional site 1) chain Q residue 17 type sequence S description BINDING SITE FOR RESIDUE MG Q 201 source : AC1 2) chain Q residue 35 type sequence T description BINDING SITE FOR RESIDUE MG Q 201 source : AC1 3) chain Q residue 57 type sequence D description BINDING SITE FOR RESIDUE MG Q 201 source : AC1 4) chain Q residue 13 type sequence G description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 5) chain Q residue 14 type sequence V description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 6) chain Q residue 15 type sequence G description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 7) chain Q residue 16 type sequence K description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 8) chain Q residue 17 type sequence S description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 9) chain Q residue 18 type sequence A description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 10) chain Q residue 28 type sequence F description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 11) chain Q residue 29 type sequence V description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 12) chain Q residue 30 type sequence D description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 13) chain Q residue 31 type sequence E description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 14) chain Q residue 32 type sequence Y description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 15) chain Q residue 34 type sequence P description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 16) chain Q residue 35 type sequence T description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 17) chain Q residue 60 type sequence G description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 18) chain Q residue 61 type sequence Q description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 19) chain Q residue 116 type sequence N description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 20) chain Q residue 117 type sequence K description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 21) chain Q residue 119 type sequence D description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 22) chain Q residue 145 type sequence S description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2 23) chain Q residue 146 type sequence A description BINDING SITE FOR RESIDUE GNP Q 202 source : AC2

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