eF-site ID 4nyi-S PDB Code 4nyi Chain S click to enlarge Title Approach for Targeting Ras with Small Molecules that Activate SOS-Mediated Nucleotide Exchange Classification SIGNALING PROTEIN Compound GTPase HRas Source Homo sapiens (Human) (SOS1_HUMAN) Sequence S:  QMRLPSADVYRFAEPDSEENIIFEENMAGIPIIKAGTVIK LIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERF EIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLR VLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKK WVESITKIIQRKKIAHNITFQSSPPTVEWHISRPGHIETF DLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDK EINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSR IIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIP SRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYL TNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQY QNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSL EIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPR Description Functional site 1) chain S residue 878 type sequence M description BINDING SITE FOR RESIDUE 2PX S 1101 source : AC3 2) chain S residue 884 type sequence Y description BINDING SITE FOR RESIDUE 2PX S 1101 source : AC3 3) chain S residue 890 type sequence F description BINDING SITE FOR RESIDUE 2PX S 1101 source : AC3 4) chain S residue 898 type sequence K description BINDING SITE FOR RESIDUE 2PX S 1101 source : AC3 5) chain S residue 902 type sequence E description BINDING SITE FOR RESIDUE 2PX S 1101 source : AC3 6) chain S residue 927-960 type prosite sequence VPFFGIYLTNILKTEEGNPEVLKRHGKELINFSK description RASGEF Ras Guanine-nucleotide exchange factors domain signature. VPFfGiyLtNIlkteegnpevlkrhgkel.................INFsK source prosite : PS00720

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