eF-site ID 4ntw-AC
PDB Code 4ntw
Chain A, C

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Title Structure of acid-sensing ion channel in complex with snake toxin
Classification TRANSPORT PROTEIN/TOXIN
Compound Acid-sensing ion channel 1
Source (PA2HB_MICTN)
Sequence A:  VVWALCFMGSLALLALVCTNRIQYYFLYPHVTKLDEVAAT
RLTFPAVTFCNLNEFRFSRVTKNDLYHAGELLALLNNRYE
IPDTQTADEKQLEILQDKANFRNFKPKPFNMLEFYDRAGH
DIREMLLSCFFRGEQCSPEDFKVVFTRYGKCYTFNAGQDG
KPRLITMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEA
GIKVQIHSQDEPPLIDQLGFGVAPGFQTFVSCQEQRLIYL
PPPWGDCKATTGEFYDTYSITACRIDCETRYLVENCNCRM
VHMPGDAPYCTPEQYKECADPALDFLVEKDNEYCVCEMPC
NVTRYGKELSMVKIPSKASAKYLAKKYNKSEQYIGENILV
LDIFFEALNYETIEQKKAYEVAGLLGDIGGQMGLFIGASI
LTVLELFDYA
C:  NLNQFRLMIKCTNDRVWADFVDYGCYCVARDSNTPVDDLD
RCCQAQKQCYDEAVKVHGCKPLVMFYSFECRYLASDLDCS
GNNTKCRNFVCNCDRTATLCILTATYNRNNHKIDPSRC
Description (1)  Acid-sensing ion channel 1, Neurotoxin MitTx-alpha, Basic phospholipase A2 homolog Tx-beta


Functional site

1) chain A
residue 71-426
type TOPO_DOM
sequence LYPHVTKLDEVAATRLTFPAVTFCNLNEFRFSRVTKNDLY
HAGELLALLNNRYEIPDTQTADEKQLEILQDKANFRNFKP
KPFNMLEFYDRAGHDIREMLLSCFFRGEQCSPEDFKVVFT
RYGKCYTFNAGQDGKPRLITMKGGTGNGLEIMLDIQQDEY
LPVWGETDETSFEAGIKVQIHSQDEPPLIDQLGFGVAPGF
QTFVSCQEQRLIYLPPPWGDCKATTGEFYDTYSITACRID
CETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFL
VEKDNEYCVCEMPCNVTRYGKELSMVKIPSKASAKYLAKK
YNKSEQYIGENILVLDIFFEALNYETIEQKKAYE
description Extracellular
source Swiss-Prot : SWS_FT_FI2

2) chain A
residue 427-453
type TRANSMEM
sequence VAGLLGDIGGQMGLFIGASILTVLELF
description Discontinuously helical
source Swiss-Prot : SWS_FT_FI3

3) chain A
residue 72
type SITE
sequence Y
description Important for channel gating
source Swiss-Prot : SWS_FT_FI4

4) chain A
residue 288
type SITE
sequence W
description Important for channel gating
source Swiss-Prot : SWS_FT_FI4

5) chain A
residue 367
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17882215, ECO:0000269|PubMed:22760635, ECO:0000269|PubMed:22842900
source Swiss-Prot : SWS_FT_FI6

6) chain A
residue 394
type CARBOHYD
sequence N
description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:17882215, ECO:0000269|PubMed:22760635, ECO:0000269|PubMed:22842900
source Swiss-Prot : SWS_FT_FI6

7) chain A
residue 80
type SITE
sequence E
description Important for channel desensitizing
source Swiss-Prot : SWS_FT_FI5

8) chain A
residue 304-324
type prosite
sequence YSITACRIDCETRYLVENCNC
description ASC Amiloride-sensitive sodium channels signature. YsiTaCridCeTryLVenCnC
source prosite : PS01206

9) chain C
residue 90-100
type prosite
sequence VCNCDRTATLC
description PA2_ASP Phospholipase A2 aspartic acid active site. VCNCDRTAtLC
source prosite : PS00119


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