eF-site ID 4nnd-G PDB Code 4nnd Chain G click to enlarge Title Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites Classification HYDROLASE Compound Tyrosine-protein phosphatase non-receptor type 18 Source Homo sapiens (Human) (ERBB2_HUMAN) Sequence G:  DSARSFLERLVLAGEFSDIQACSAAWKADGVCSTVAGSRP ENVRKNRYKDVLPYDQTRVILSLLQEEHSDYINGNFIRGV DGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIE NGRKRCERYWAQEQEPLQTGLFCITLIKEKWLNEDIMLRT LKVTFQKESRSVYQLQYMSWPDRGVPSPDHMLAMVEEARR LQGSGPEPLCVHSSAGCGRTGVLCTVDYVRQLLLTQMIPP DFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCS Description (1)  Tyrosine-protein phosphatase non-receptor type 18 (E.C.3.1.3.48), phosphorylated peptide Functional site 1) chain G residue 62 type sequence Y description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 2) chain G residue 63 type sequence K description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 3) chain G residue 64 type sequence D description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 4) chain G residue 65 type sequence V description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 5) chain G residue 138 type sequence R description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 6) chain G residue 197 type sequence D description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 7) chain G residue 198 type sequence R description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 8) chain G residue 229 type sequence S description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 9) chain G residue 230 type sequence S description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 10) chain G residue 231 type sequence A description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 11) chain G residue 232 type sequence G description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 12) chain G residue 233 type sequence C description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 13) chain G residue 234 type sequence G description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 14) chain G residue 235 type sequence R description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 15) chain G residue 276 type sequence Q description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 16) chain G residue 197 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 17) chain G residue 229 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 18) chain G residue 276 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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