eF-site ID 4nnd-B PDB Code 4nnd Chain B click to enlarge Title Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites Classification HYDROLASE Compound Tyrosine-protein phosphatase non-receptor type 18 Source Homo sapiens (Human) (ERBB2_HUMAN) Sequence B:  DSARSFLERLEARVLAGEFSDIQACSAAWKADGVCSTVAG SRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNF IRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMAC REIENGRKRCERYWAQEQEPLQTGLFCITLIKEKWLNEDI MLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMV EEARRLQGSGPEPLCVHSSAGCGRTGVLCTVDYVRQLLLT QMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM FCS Description (1)  Tyrosine-protein phosphatase non-receptor type 18 (E.C.3.1.3.48), phosphorylated peptide Functional site 1) chain B residue 62 type sequence Y description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 2) chain B residue 63 type sequence K description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 3) chain B residue 64 type sequence D description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 4) chain B residue 197 type sequence D description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 5) chain B residue 198 type sequence R description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 6) chain B residue 229 type sequence S description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 7) chain B residue 230 type sequence S description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 8) chain B residue 231 type sequence A description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 9) chain B residue 232 type sequence G description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 10) chain B residue 233 type sequence C description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 11) chain B residue 234 type sequence G description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 12) chain B residue 235 type sequence R description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 13) chain B residue 276 type sequence Q description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 14) chain B residue 197 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 15) chain B residue 229 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 16) chain B residue 276 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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