eF-site ID 4nnd-ABCDEFGH PDB Code 4nnd Chain A, B, C, D, E, F, G, H click to enlarge Title Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites Classification HYDROLASE Compound Tyrosine-protein phosphatase non-receptor type 18 Source Homo sapiens (Human) (ERBB2_HUMAN) Sequence A:  DSARSFLERLEARAVLAGEFSDIQACSAAWKADGVCSTVA GSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGN FIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMA CREIENGRKRCERYWAQEQEPLQTGLFCITLIKEKWLNED IMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAM VEEARRLQGSGPEPLCVHSSAGCGRTGVLCTVDYVRQLLL TMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM FCS B:  DSARSFLERLEARVLAGEFSDIQACSAAWKADGVCSTVAG SRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNF IRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMAC REIENGRKRCERYWAQEQEPLQTGLFCITLIKEKWLNEDI MLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMV EEARRLQGSGPEPLCVHSSAGCGRTGVLCTVDYVRQLLLT QMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM FCS C:  LQRXSE D:  DSARSFLERLEAVLAGEFSDIQACSAAWKADGVCSTVAGS RPENVRKNRYKDVLPYDQTRVILSLLQEEHSDYINGNFIR GVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACRE IENGRKRCERYWAQEQEPLQTGLFCITLIKEKWLNEDIML RTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEE ARRLQGSGPEPLCVHSSAGCGRTGVLCTVDYVRQLLLTQM IPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC S E:  LQRXS F:  LQRXSE G:  DSARSFLERLVLAGEFSDIQACSAAWKADGVCSTVAGSRP ENVRKNRYKDVLPYDQTRVILSLLQEEHSDYINGNFIRGV DGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACREIE NGRKRCERYWAQEQEPLQTGLFCITLIKEKWLNEDIMLRT LKVTFQKESRSVYQLQYMSWPDRGVPSPDHMLAMVEEARR LQGSGPEPLCVHSSAGCGRTGVLCTVDYVRQLLLTQMIPP DFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFCS H:  LQRXS Description (1)  Tyrosine-protein phosphatase non-receptor type 18 (E.C.3.1.3.48), phosphorylated peptide Functional site 1) chain B residue 62 type sequence Y description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 2) chain B residue 63 type sequence K description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 3) chain B residue 64 type sequence D description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 4) chain B residue 197 type sequence D description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 5) chain B residue 198 type sequence R description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 6) chain B residue 229 type sequence S description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 7) chain B residue 230 type sequence S description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 8) chain B residue 231 type sequence A description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 9) chain B residue 232 type sequence G description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 10) chain B residue 233 type sequence C description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 11) chain B residue 234 type sequence G description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 12) chain B residue 235 type sequence R description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 13) chain B residue 276 type sequence Q description BINDING SITE FOR CHAIN C OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC1 14) chain D residue 62 type sequence Y description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 15) chain D residue 63 type sequence K description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 16) chain D residue 64 type sequence D description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 17) chain D residue 140 type sequence R description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 18) chain D residue 197 type sequence D description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 19) chain D residue 198 type sequence R description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 20) chain D residue 229 type sequence S description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 21) chain D residue 230 type sequence S description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 22) chain D residue 231 type sequence A description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 23) chain D residue 232 type sequence G description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 24) chain D residue 233 type sequence C description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 25) chain D residue 234 type sequence G description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 26) chain D residue 235 type sequence R description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 27) chain D residue 276 type sequence Q description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 28) chain A residue 62 type sequence Y description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 29) chain A residue 63 type sequence K description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 30) chain A residue 64 type sequence D description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 31) chain A residue 197 type sequence D description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 32) chain A residue 198 type sequence R description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 33) chain A residue 229 type sequence S description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 34) chain A residue 230 type sequence S description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 35) chain A residue 231 type sequence A description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 36) chain A residue 232 type sequence G description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 37) chain A residue 233 type sequence C description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 38) chain A residue 234 type sequence G description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 39) chain A residue 235 type sequence R description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 40) chain A residue 276 type sequence Q description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 41) chain G residue 62 type sequence Y description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 42) chain G residue 63 type sequence K description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 43) chain G residue 64 type sequence D description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 44) chain G residue 65 type sequence V description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 45) chain G residue 138 type sequence R description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 46) chain G residue 197 type sequence D description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 47) chain G residue 198 type sequence R description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 48) chain G residue 229 type sequence S description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 49) chain G residue 230 type sequence S description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 50) chain G residue 231 type sequence A description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 51) chain G residue 232 type sequence G description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 52) chain G residue 233 type sequence C description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 53) chain G residue 234 type sequence G description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 54) chain G residue 235 type sequence R description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 55) chain G residue 276 type sequence Q description BINDING SITE FOR CHAIN H OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC4 56) chain C residue 112 type MOD_RES sequence X description Phosphotyrosine => ECO:0000269|PubMed:27134172 source Swiss-Prot : SWS_FT_FI1 57) chain E residue 112 type MOD_RES sequence X description Phosphotyrosine => ECO:0000269|PubMed:27134172 source Swiss-Prot : SWS_FT_FI1 58) chain H residue 112 type MOD_RES sequence X description Phosphotyrosine => ECO:0000269|PubMed:27134172 source Swiss-Prot : SWS_FT_FI1 59) chain F residue 112 type MOD_RES sequence X description Phosphotyrosine => ECO:0000269|PubMed:27134172 source Swiss-Prot : SWS_FT_FI1 60) chain G residue 197 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 61) chain G residue 229 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 62) chain G residue 276 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 63) chain D residue 276 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 64) chain A residue 276 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 65) chain B residue 197 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 66) chain B residue 229 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 67) chain B residue 276 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 68) chain D residue 197 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 69) chain D residue 229 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 70) chain A residue 197 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 71) chain A residue 229 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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