eF-site ID 4nnd-A PDB Code 4nnd Chain A click to enlarge Title Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites Classification HYDROLASE Compound Tyrosine-protein phosphatase non-receptor type 18 Source Homo sapiens (Human) (ERBB2_HUMAN) Sequence A:  DSARSFLERLEARAVLAGEFSDIQACSAAWKADGVCSTVA GSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGN FIRGVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMA CREIENGRKRCERYWAQEQEPLQTGLFCITLIKEKWLNED IMLRTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAM VEEARRLQGSGPEPLCVHSSAGCGRTGVLCTVDYVRQLLL TMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQM FCS Description (1)  Tyrosine-protein phosphatase non-receptor type 18 (E.C.3.1.3.48), phosphorylated peptide Functional site 1) chain A residue 62 type sequence Y description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 2) chain A residue 63 type sequence K description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 3) chain A residue 64 type sequence D description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 4) chain A residue 197 type sequence D description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 5) chain A residue 198 type sequence R description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 6) chain A residue 229 type sequence S description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 7) chain A residue 230 type sequence S description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 8) chain A residue 231 type sequence A description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 9) chain A residue 232 type sequence G description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 10) chain A residue 233 type sequence C description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 11) chain A residue 234 type sequence G description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 12) chain A residue 235 type sequence R description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 13) chain A residue 276 type sequence Q description BINDING SITE FOR CHAIN F OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC3 14) chain A residue 197 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 15) chain A residue 229 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 276 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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