eF-site ID 4nnd-D PDB Code 4nnd Chain D click to enlarge Title Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites Classification HYDROLASE Compound Tyrosine-protein phosphatase non-receptor type 18 Source Homo sapiens (Human) (ERBB2_HUMAN) Sequence D:  DSARSFLERLEAVLAGEFSDIQACSAAWKADGVCSTVAGS RPENVRKNRYKDVLPYDQTRVILSLLQEEHSDYINGNFIR GVDGSLAYIATQGPLPHTLLDFWRLVWEFGVKVILMACRE IENGRKRCERYWAQEQEPLQTGLFCITLIKEKWLNEDIML RTLKVTFQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEE ARRLQGSGPEPLCVHSSAGCGRTGVLCTVDYVRQLLLTQM IPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC S Description (1)  Tyrosine-protein phosphatase non-receptor type 18 (E.C.3.1.3.48), phosphorylated peptide Functional site 1) chain D residue 62 type sequence Y description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 2) chain D residue 63 type sequence K description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 3) chain D residue 64 type sequence D description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 4) chain D residue 140 type sequence R description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 5) chain D residue 197 type sequence D description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 6) chain D residue 198 type sequence R description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 7) chain D residue 229 type sequence S description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 8) chain D residue 230 type sequence S description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 9) chain D residue 231 type sequence A description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 10) chain D residue 232 type sequence G description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 11) chain D residue 233 type sequence C description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 12) chain D residue 234 type sequence G description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 13) chain D residue 235 type sequence R description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 14) chain D residue 276 type sequence Q description BINDING SITE FOR CHAIN E OF RECEPTOR TYROSINE-PROTEIN KINASE ERBB-2 source : AC2 15) chain D residue 276 type BINDING sequence Q description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 16) chain D residue 197 type BINDING sequence D description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 17) chain D residue 229 type BINDING sequence S description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2

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