eF-site ID 4nea-A PDB Code 4nea Chain A click to enlarge Title 1.90 Angstrom resolution crystal structure of betaine aldehyde dehydrogenase (betB) from Staphylococcus aureus in complex with NAD+ and BME-free Cys289 Classification OXIDOREDUCTASE Compound Betaine aldehyde dehydrogenase Source (Q5HCU0_STAAC) Sequence A:  MHHHHHHSAMELLKHLSQRQYIDGEWVESANKNTRDIINP YNQEVIFTVSEGTKEDAERAILAARRAFESGEWSQETAET RGKKVRAIADKIKEHREALARLETLDTGKTLEESYADMDD IHNVFMYFAGLADKDGGEMIDSPIPDTESKIVKEPVGVVT QITPWNYPLLQASWKIAPALATGCSLVMKPSEITPLTTIR VFELMEEVGFPKGTINLILGAGSEVGDVMSGHKEVDLVSF TGGIETGKHIMKNAANNVTNIALELGGKNPNIIFDDADFE LAVDQALNGGYFHAGQVCSAGSRILVQNSIKDKFEQALID RVKKIKLGNGFDADTEMGPVISTEHRNKIESYMDVAKAEG ATIAVGGKRPDRDDLKDGLFFEPTVITNCDTSMRIVQEEV FGPVVTVEGFETEQEAIQLANDSIYGLAGAVFSKDIGKAQ RVANKLKLGTVWINDFHPYFAQAPWGGYKQSGIGRELGKE GLEEYLVSKHILTNTNPQLVNWFSK Description Functional site 1) chain A residue 153 type sequence I description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 2) chain A residue 154 type sequence T description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 3) chain A residue 155 type sequence P description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 4) chain A residue 156 type sequence W description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 5) chain A residue 157 type sequence N description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 6) chain A residue 180 type sequence K description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 7) chain A residue 182 type sequence S description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 8) chain A residue 183 type sequence E description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 9) chain A residue 212 type sequence A description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 10) chain A residue 213 type sequence G description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 11) chain A residue 217 type sequence G description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 12) chain A residue 218 type sequence D description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 13) chain A residue 231 type sequence F description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 14) chain A residue 232 type sequence T description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 15) chain A residue 233 type sequence G description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 16) chain A residue 234 type sequence G description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 17) chain A residue 237 type sequence T description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 18) chain A residue 240 type sequence H description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 19) chain A residue 241 type sequence I description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 20) chain A residue 255 type sequence E description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 21) chain A residue 257 type sequence G description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 22) chain A residue 289 type sequence C description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 23) chain A residue 336 type sequence H description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 24) chain A residue 390 type sequence E description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 25) chain A residue 392 type sequence F description BINDING SITE FOR RESIDUE NAD A 501 source : AC1 26) chain A residue 29 type sequence I description BINDING SITE FOR RESIDUE K A 502 source : AC2 27) chain A residue 97 type sequence D description BINDING SITE FOR RESIDUE K A 502 source : AC2 28) chain A residue 184 type sequence I description BINDING SITE FOR RESIDUE K A 502 source : AC2 29) chain A residue 460 type sequence K description BINDING SITE FOR RESIDUE K A 503 source : AC3 30) chain A residue 463 type sequence G description BINDING SITE FOR RESIDUE K A 503 source : AC3 31) chain A residue 249 type sequence V description BINDING SITE FOR RESIDUE K A 504 source : AC4 32) chain A residue 251 type sequence N description BINDING SITE FOR RESIDUE K A 504 source : AC4 33) chain A residue 474 type sequence E description BINDING SITE FOR RESIDUE K A 505 source : AC5 34) chain A residue 477 type sequence L description BINDING SITE FOR RESIDUE K A 505 source : AC5 35) chain A residue 224 type sequence K description BINDING SITE FOR RESIDUE K A 506 source : AC6 36) chain A residue 226 type sequence V description BINDING SITE FOR RESIDUE K A 506 source : AC6 37) chain A residue 248 type sequence N description BINDING SITE FOR RESIDUE K A 506 source : AC6 38) chain A residue 250 type sequence T description BINDING SITE FOR RESIDUE K A 506 source : AC6 39) chain A residue 282-293 type prosite sequence YFHAGQVCSAGS description ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. YfHAGQVCSAGS source prosite : PS00070 40) chain A residue 254-261 type prosite sequence LELGGKNP description ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKNP source prosite : PS00687

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