eF-site ID 4ncj-ABCD PDB Code 4ncj Chain A, B, C, D Title Crystal Structure of Pyrococcus furiosis Rad50 R805E mutation with ADP Beryllium Flouride Classification DNA BINDING PROTEIN Compound DNA double-strand break repair Rad50 ATPase Source Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) (RAD50_PYRFU) Sequence A:  MKLERVTVKNFRSHSDTVVEFKEGINLIIGQNGSGKSSLL DAILVGLYWPLRIKDIKKDEFTKVGARDTYIDLIFEKDGT KYRITRRFLKGYSSGEIHAMKRLVGNEWKHVTEPSSKAIS AFMEKLIPYNIFLNAIYIRQGQIDAILESDEAREKVVREV LNLKYKALAREAALSKIGELASEIFAEFTEGKYSEVVVRA EENKVRLFVVWEGKERPLTFLSGGERIALGLAFELAMSLY LAGEISLLILDEPTPYLDEERRRKLITIMERYLKKIPQVI LVSHDEELKDAADHVIRISLENGSSKVEVVS B:  MKLERVTVKNFRSHSDTVVEFKEGINLIIGQNGSGKSSLL DAILVGLYWPLRIKDIKKDEFTKVGARDTYIDLIFEKDGT KYRITRRFLKGYSSGEIHAMKRLVGNEWKHVTEPSSKAIS AFMEKLIPYNIFLNAIYIRQGQIDAILESDEAREKVVREV LNLDYKALAREAALSKIGELASEIFAEFTEGKYSEVVVRA EENKVRLFVVWEGKERPLTFLSGGERIALGLAFELAMSLY LAGEISLLILDEPTPYLDEERRRKLITIMERYLKKIPQVI LVSHDEELKDAADHVIRISLENGSSKVEVVS C:  MKLERVTVKNFRSHSDTVVEFKEGINLIIGQNGSGKSSLL DAILVGLYWPLRIKDIKKDEFTKVGARDTYIDLIFEKDGT KYRITRRFLKGYSSGEIHAMKRLVGNEWKHVTEPSSKAIS AFMEKLIPYNIFLNAIYIRQGQIDAILESDEAREKVVREV LNLTEELIEKVKKYKALAREAALSKIGELASEIFAEFTEG KYSEVVVRAEENKVRLFVVWEGKERPLTFLSGGERIALGL AFELAMSLYLAGEISLLILDEPTPYLDEERRRKLITIMER YLKKIPQVILVSHDEELKDAADHVIRISLENGSSKVEVVS D:  MKLERVTVKNFRSHSDTVVEFKEGINLIIGQNGSGKSSLL DAILVGLYWPLRIKDIKKDEFTKVGARDTYIDLIFEKDGT KYRITRRFLKGYSSGEIHAMKRLVGNEWKHVTEPSSKAIS AFMEKLIPYNIFLNAIYIRQGQIDAILESDEAREKVVREV LNLDTEELIEKVKKYKALAREAALSKIGELASEIFAEFTE GKYSEVVVRAEENKVRLFVVWEGKERPLTFLSGGERIALG LAFELAMSLYLAGEISLLILDEPTPYLDEERRRKLITIME RYLKKIPQVILVSHDEELKDAADHVIRISLENGSSKVEVV S Description Functional site 1) chain A residue 12 type sequence R description BINDING SITE FOR RESIDUE ADP A 901 source : AC1 2) chain A residue 13 type sequence S description BINDING SITE FOR RESIDUE ADP A 901 source : AC1 3) chain A residue 33 type sequence G description BINDING SITE FOR RESIDUE ADP A 901 source : AC1 4) chain A residue 34 type sequence S description BINDING SITE FOR RESIDUE ADP A 901 source : AC1 5) chain A residue 35 type sequence G description BINDING SITE FOR RESIDUE ADP A 901 source : AC1 6) chain A residue 36 type sequence K description BINDING SITE FOR RESIDUE ADP A 901 source : AC1 7) chain A residue 37 type sequence S description BINDING SITE FOR RESIDUE ADP A 901 source : AC1 8) chain A residue 38 type sequence S description BINDING SITE FOR RESIDUE ADP A 901 source : AC1 9) chain A residue 60 type sequence E description BINDING SITE FOR RESIDUE ADP A 901 source : AC1 10) chain A residue 62 type sequence T description BINDING SITE FOR RESIDUE ADP A 901 source : AC1 11) chain A residue 63 type sequence K description BINDING SITE FOR RESIDUE ADP A 901 source : AC1 12) chain A residue 64 type sequence V description BINDING SITE FOR RESIDUE ADP A 901 source : AC1 13) chain C residue 763 type sequence K description BINDING SITE FOR RESIDUE ADP A 901 source : AC1 14) chain C residue 764 type sequence Y description BINDING SITE FOR RESIDUE ADP A 901 source : AC1 15) chain C residue 791 type sequence F description BINDING SITE FOR RESIDUE ADP A 901 source : AC1 16) chain C residue 793 type sequence S description BINDING SITE FOR RESIDUE ADP A 901 source : AC1 17) chain C residue 796 type sequence E description BINDING SITE FOR RESIDUE ADP A 901 source : AC1 18) chain A residue 32 type sequence N description BINDING SITE FOR RESIDUE BEF A 902 source : AC2 19) chain A residue 33 type sequence G description BINDING SITE FOR RESIDUE BEF A 902 source : AC2 20) chain A residue 36 type sequence K description BINDING SITE FOR RESIDUE BEF A 902 source : AC2 21) chain A residue 140 type sequence Q description BINDING SITE FOR RESIDUE BEF A 902 source : AC2 22) chain C residue 793 type sequence S description BINDING SITE FOR RESIDUE BEF A 902 source : AC2 23) chain C residue 794 type sequence G description BINDING SITE FOR RESIDUE BEF A 902 source : AC2 24) chain C residue 795 type sequence G description BINDING SITE FOR RESIDUE BEF A 902 source : AC2 25) chain A residue 37 type sequence S description BINDING SITE FOR RESIDUE MG A 903 source : AC3 26) chain A residue 140 type sequence Q description BINDING SITE FOR RESIDUE MG A 903 source : AC3 27) chain B residue 12 type sequence R description BINDING SITE FOR RESIDUE ADP B 901 source : AC4 28) chain B residue 13 type sequence S description BINDING SITE FOR RESIDUE ADP B 901 source : AC4 29) chain B residue 32 type sequence N description BINDING SITE FOR RESIDUE ADP B 901 source : AC4 30) chain B residue 33 type sequence G description BINDING SITE FOR RESIDUE ADP B 901 source : AC4 31) chain B residue 34 type sequence S description BINDING SITE FOR RESIDUE ADP B 901 source : AC4 32) chain B residue 35 type sequence G description BINDING SITE FOR RESIDUE ADP B 901 source : AC4 33) chain B residue 36 type sequence K description BINDING SITE FOR RESIDUE ADP B 901 source : AC4 34) chain B residue 37 type sequence S description BINDING SITE FOR RESIDUE ADP B 901 source : AC4 35) chain B residue 38 type sequence S description BINDING SITE FOR RESIDUE ADP B 901 source : AC4 36) chain B residue 60 type sequence E description BINDING SITE FOR RESIDUE ADP B 901 source : AC4 37) chain B residue 62 type sequence T description BINDING SITE FOR RESIDUE ADP B 901 source : AC4 38) chain B residue 63 type sequence K description BINDING SITE FOR RESIDUE ADP B 901 source : AC4 39) chain B residue 64 type sequence V description BINDING SITE FOR RESIDUE ADP B 901 source : AC4 40) chain D residue 763 type sequence K description BINDING SITE FOR RESIDUE ADP B 901 source : AC4 41) chain D residue 764 type sequence Y description BINDING SITE FOR RESIDUE ADP B 901 source : AC4 42) chain D residue 791 type sequence F description BINDING SITE FOR RESIDUE ADP B 901 source : AC4 43) chain D residue 793 type sequence S description BINDING SITE FOR RESIDUE ADP B 901 source : AC4 44) chain D residue 796 type sequence E description BINDING SITE FOR RESIDUE ADP B 901 source : AC4 45) chain B residue 32 type sequence N description BINDING SITE FOR RESIDUE BEF B 902 source : AC5 46) chain B residue 33 type sequence G description BINDING SITE FOR RESIDUE BEF B 902 source : AC5 47) chain B residue 36 type sequence K description BINDING SITE FOR RESIDUE BEF B 902 source : AC5 48) chain B residue 140 type sequence Q description BINDING SITE FOR RESIDUE BEF B 902 source : AC5 49) chain D residue 793 type sequence S description BINDING SITE FOR RESIDUE BEF B 902 source : AC5 50) chain D residue 794 type sequence G description BINDING SITE FOR RESIDUE BEF B 902 source : AC5 51) chain D residue 795 type sequence G description BINDING SITE FOR RESIDUE BEF B 902 source : AC5 52) chain B residue 37 type sequence S description BINDING SITE FOR RESIDUE MG B 903 source : AC6 53) chain B residue 140 type sequence Q description BINDING SITE FOR RESIDUE MG B 903 source : AC6 54) chain A residue 763 type sequence K description BINDING SITE FOR RESIDUE ADP C 901 source : AC7 55) chain A residue 764 type sequence Y description BINDING SITE FOR RESIDUE ADP C 901 source : AC7 56) chain A residue 791 type sequence F description BINDING SITE FOR RESIDUE ADP C 901 source : AC7 57) chain A residue 793 type sequence S description BINDING SITE FOR RESIDUE ADP C 901 source : AC7 58) chain A residue 796 type sequence E description BINDING SITE FOR RESIDUE ADP C 901 source : AC7 59) chain C residue 12 type sequence R description BINDING SITE FOR RESIDUE ADP C 901 source : AC7 60) chain C residue 13 type sequence S description BINDING SITE FOR RESIDUE ADP C 901 source : AC7 61) chain C residue 32 type sequence N description BINDING SITE FOR RESIDUE ADP C 901 source : AC7 62) chain C residue 33 type sequence G description BINDING SITE FOR RESIDUE ADP C 901 source : AC7 63) chain C residue 34 type sequence S description BINDING SITE FOR RESIDUE ADP C 901 source : AC7 64) chain C residue 35 type sequence G description BINDING SITE FOR RESIDUE ADP C 901 source : AC7 65) chain C residue 36 type sequence K description BINDING SITE FOR RESIDUE ADP C 901 source : AC7 66) chain C residue 37 type sequence S description BINDING SITE FOR RESIDUE ADP C 901 source : AC7 67) chain C residue 38 type sequence S description BINDING SITE FOR RESIDUE ADP C 901 source : AC7 68) chain C residue 60 type sequence E description BINDING SITE FOR RESIDUE ADP C 901 source : AC7 69) chain C residue 62 type sequence T description BINDING SITE FOR RESIDUE ADP C 901 source : AC7 70) chain C residue 63 type sequence K description BINDING SITE FOR RESIDUE ADP C 901 source : AC7 71) chain C residue 64 type sequence V description BINDING SITE FOR RESIDUE ADP C 901 source : AC7 72) chain A residue 793 type sequence S description BINDING SITE FOR RESIDUE BEF C 902 source : AC8 73) chain A residue 794 type sequence G description BINDING SITE FOR RESIDUE BEF C 902 source : AC8 74) chain A residue 795 type sequence G description BINDING SITE FOR RESIDUE BEF C 902 source : AC8 75) chain C residue 32 type sequence N description BINDING SITE FOR RESIDUE BEF C 902 source : AC8 76) chain C residue 33 type sequence G description BINDING SITE FOR RESIDUE BEF C 902 source : AC8 77) chain C residue 36 type sequence K description BINDING SITE FOR RESIDUE BEF C 902 source : AC8 78) chain C residue 140 type sequence Q description BINDING SITE FOR RESIDUE BEF C 902 source : AC8 79) chain C residue 37 type sequence S description BINDING SITE FOR RESIDUE MG C 903 source : AC9 80) chain C residue 140 type sequence Q description BINDING SITE FOR RESIDUE MG C 903 source : AC9 81) chain B residue 763 type sequence K description BINDING SITE FOR RESIDUE ADP D 901 source : BC1 82) chain B residue 764 type sequence Y description BINDING SITE FOR RESIDUE ADP D 901 source : BC1 83) chain B residue 791 type sequence F description BINDING SITE FOR RESIDUE ADP D 901 source : BC1 84) chain B residue 793 type sequence S description BINDING SITE FOR RESIDUE ADP D 901 source : BC1 85) chain B residue 796 type sequence E description BINDING SITE FOR RESIDUE ADP D 901 source : BC1 86) chain D residue 12 type sequence R description BINDING SITE FOR RESIDUE ADP D 901 source : BC1 87) chain D residue 13 type sequence S description BINDING SITE FOR RESIDUE ADP D 901 source : BC1 88) chain D residue 32 type sequence N description BINDING SITE FOR RESIDUE ADP D 901 source : BC1 89) chain D residue 33 type sequence G description BINDING SITE FOR RESIDUE ADP D 901 source : BC1 90) chain D residue 34 type sequence S description BINDING SITE FOR RESIDUE ADP D 901 source : BC1 91) chain D residue 35 type sequence G description BINDING SITE FOR RESIDUE ADP D 901 source : BC1 92) chain D residue 36 type sequence K description BINDING SITE FOR RESIDUE ADP D 901 source : BC1 93) chain D residue 37 type sequence S description BINDING SITE FOR RESIDUE ADP D 901 source : BC1 94) chain D residue 38 type sequence S description BINDING SITE FOR RESIDUE ADP D 901 source : BC1 95) chain D residue 60 type sequence E description BINDING SITE FOR RESIDUE ADP D 901 source : BC1 96) chain D residue 62 type sequence T description BINDING SITE FOR RESIDUE ADP D 901 source : BC1 97) chain D residue 63 type sequence K description BINDING SITE FOR RESIDUE ADP D 901 source : BC1 98) chain D residue 64 type sequence V description BINDING SITE FOR RESIDUE ADP D 901 source : BC1 99) chain B residue 793 type sequence S description BINDING SITE FOR RESIDUE BEF D 902 source : BC2 100) chain B residue 794 type sequence G description BINDING SITE FOR RESIDUE BEF D 902 source : BC2 101) chain B residue 795 type sequence G description BINDING SITE FOR RESIDUE BEF D 902 source : BC2 102) chain D residue 32 type sequence N description BINDING SITE FOR RESIDUE BEF D 902 source : BC2 103) chain D residue 33 type sequence G description BINDING SITE FOR RESIDUE BEF D 902 source : BC2 104) chain D residue 36 type sequence K description BINDING SITE FOR RESIDUE BEF D 902 source : BC2 105) chain D residue 140 type sequence Q description BINDING SITE FOR RESIDUE BEF D 902 source : BC2 106) chain D residue 37 type sequence S description BINDING SITE FOR RESIDUE MG D 903 source : BC3 107) chain D residue 140 type sequence Q description BINDING SITE FOR RESIDUE MG D 903 source : BC3 108) chain A residue 763 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT source Swiss-Prot : SWS_FT_FI3 109) chain A residue 791 type BINDING sequence F description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT source Swiss-Prot : SWS_FT_FI3 110) chain B residue 763 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT source Swiss-Prot : SWS_FT_FI3 111) chain B residue 791 type BINDING sequence F description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT source Swiss-Prot : SWS_FT_FI3 112) chain C residue 763 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT source Swiss-Prot : SWS_FT_FI3 113) chain C residue 791 type BINDING sequence F description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT source Swiss-Prot : SWS_FT_FI3 114) chain D residue 763 type BINDING sequence K description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT source Swiss-Prot : SWS_FT_FI3 115) chain D residue 791 type BINDING sequence F description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT source Swiss-Prot : SWS_FT_FI3 116) chain A residue 12 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0000269|PubMed:24493214, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT, ECO:0007744|PDB:3QKU, ECO:0007744|PDB:4NCJ source Swiss-Prot : SWS_FT_FI1 117) chain D residue 12 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0000269|PubMed:24493214, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT, ECO:0007744|PDB:3QKU, ECO:0007744|PDB:4NCJ source Swiss-Prot : SWS_FT_FI1 118) chain D residue 32 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0000269|PubMed:24493214, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT, ECO:0007744|PDB:3QKU, ECO:0007744|PDB:4NCJ source Swiss-Prot : SWS_FT_FI1 119) chain D residue 60 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0000269|PubMed:24493214, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT, ECO:0007744|PDB:3QKU, ECO:0007744|PDB:4NCJ source Swiss-Prot : SWS_FT_FI1 120) chain A residue 32 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0000269|PubMed:24493214, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT, ECO:0007744|PDB:3QKU, ECO:0007744|PDB:4NCJ source Swiss-Prot : SWS_FT_FI1 121) chain A residue 60 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0000269|PubMed:24493214, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT, ECO:0007744|PDB:3QKU, ECO:0007744|PDB:4NCJ source Swiss-Prot : SWS_FT_FI1 122) chain B residue 12 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0000269|PubMed:24493214, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT, ECO:0007744|PDB:3QKU, ECO:0007744|PDB:4NCJ source Swiss-Prot : SWS_FT_FI1 123) chain B residue 32 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0000269|PubMed:24493214, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT, ECO:0007744|PDB:3QKU, ECO:0007744|PDB:4NCJ source Swiss-Prot : SWS_FT_FI1 124) chain B residue 60 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0000269|PubMed:24493214, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT, ECO:0007744|PDB:3QKU, ECO:0007744|PDB:4NCJ source Swiss-Prot : SWS_FT_FI1 125) chain C residue 12 type BINDING sequence R description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0000269|PubMed:24493214, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT, ECO:0007744|PDB:3QKU, ECO:0007744|PDB:4NCJ source Swiss-Prot : SWS_FT_FI1 126) chain C residue 32 type BINDING sequence N description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0000269|PubMed:24493214, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT, ECO:0007744|PDB:3QKU, ECO:0007744|PDB:4NCJ source Swiss-Prot : SWS_FT_FI1 127) chain C residue 60 type BINDING sequence E description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0000269|PubMed:24493214, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT, ECO:0007744|PDB:3QKU, ECO:0007744|PDB:4NCJ source Swiss-Prot : SWS_FT_FI1 128) chain A residue 140 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT, ECO:0007744|PDB:3QKU source Swiss-Prot : SWS_FT_FI2 129) chain B residue 140 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT, ECO:0007744|PDB:3QKU source Swiss-Prot : SWS_FT_FI2 130) chain C residue 140 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT, ECO:0007744|PDB:3QKU source Swiss-Prot : SWS_FT_FI2 131) chain D residue 140 type BINDING sequence Q description BINDING => ECO:0000269|PubMed:10892749, ECO:0000269|PubMed:21441914, ECO:0007744|PDB:1F2U, ECO:0007744|PDB:3QKT, ECO:0007744|PDB:3QKU source Swiss-Prot : SWS_FT_FI2

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