eF-site ID 4nca-B PDB Code 4nca Chain B click to enlarge Title Structure of Thermus thermophilus Argonaute bound to guide DNA 19-mer and target DNA in the presence of Mg2+ Classification NUCLEAR PROTEIN/DNA Compound Argonaute Source Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (4NCA) Sequence B:  LGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVY PLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMG QTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRR LEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAF LLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWE LLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAW VADPKKPIPHLTGLLVPVLTLEDLHEEGSLALSLPWEERR RRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAV SKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLR AFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVL VLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRW ENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRF GGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETL WAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIA YDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVH RDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGF AFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV Description Functional site 1) chain B residue 37 type sequence P description BINDING SITE FOR RESIDUE DT A 701 source : AC1 2) chain B residue 38 type sequence G description BINDING SITE FOR RESIDUE DT A 701 source : AC1 3) chain B residue 39 type sequence R description BINDING SITE FOR RESIDUE DT A 701 source : AC1 4) chain B residue 195 type sequence N description BINDING SITE FOR RESIDUE DT B 701 source : AC3 5) chain B residue 197 type sequence Y description BINDING SITE FOR RESIDUE DT B 701 source : AC3 6) chain B residue 200 type sequence R description BINDING SITE FOR RESIDUE DT B 701 source : AC3 7) chain B residue 217 type sequence L description BINDING SITE FOR RESIDUE DT B 701 source : AC3 8) chain B residue 218 type sequence P description BINDING SITE FOR RESIDUE DT B 701 source : AC3 9) chain B residue 223 type sequence L description BINDING SITE FOR RESIDUE DT B 701 source : AC3 10) chain B residue 226 type sequence Y description BINDING SITE FOR RESIDUE DT B 701 source : AC3 11) chain B residue 227 type sequence H description BINDING SITE FOR RESIDUE DT B 701 source : AC3 12) chain B residue 232 type sequence R description BINDING SITE FOR RESIDUE DT B 701 source : AC3 13) chain B residue 254 type sequence I description BINDING SITE FOR RESIDUE DT B 701 source : AC3 14) chain B residue 255 type sequence P description BINDING SITE FOR RESIDUE DT B 701 source : AC3 15) chain B residue 256 type sequence H description BINDING SITE FOR RESIDUE DT B 701 source : AC3 16) chain B residue 478 type sequence D description BINDING SITE FOR RESIDUE MG B 702 source : AC4 17) chain B residue 660 type sequence D description BINDING SITE FOR RESIDUE MG B 702 source : AC4 18) chain B residue 478 type sequence D description BINDING SITE FOR RESIDUE MG B 703 source : AC5 19) chain B residue 479 type sequence A description BINDING SITE FOR RESIDUE MG B 703 source : AC5 20) chain B residue 546 type sequence D description BINDING SITE FOR RESIDUE MG B 703 source : AC5 21) chain B residue 685 type sequence V description BINDING SITE FOR RESIDUE MG E 101 source : AC8 22) chain B residue 478 type ACT_SITE sequence D description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094 source Swiss-Prot : SWS_FT_FI1 23) chain B residue 546 type ACT_SITE sequence D description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094 source Swiss-Prot : SWS_FT_FI1 24) chain B residue 660 type ACT_SITE sequence D description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094 source Swiss-Prot : SWS_FT_FI1 25) chain B residue 512 type ACT_SITE sequence E description ACT_SITE => ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094 source Swiss-Prot : SWS_FT_FI2 26) chain B residue 478 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76 source Swiss-Prot : SWS_FT_FI3 27) chain B residue 546 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76 source Swiss-Prot : SWS_FT_FI4 28) chain B residue 660 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76 source Swiss-Prot : SWS_FT_FI4 29) chain B residue 685 type BINDING sequence V description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76 source Swiss-Prot : SWS_FT_FI5

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