eF-site ID 4nca-ABCDEFGH
PDB Code 4nca
Chain A, B, C, D, E, F, G, H

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Title Structure of Thermus thermophilus Argonaute bound to guide DNA 19-mer and target DNA in the presence of Mg2+
Classification NUCLEAR PROTEIN/DNA
Compound Argonaute
Source Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (4NCA)
Sequence A:  HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEV
YPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARM
GQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLR
RLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGA
FLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTW
ELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVA
WVADPKDPRKPIPHLTGLLVPVLTLEDLHEEEGSLALSLP
WEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLM
GRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLR
RALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEG
VQAVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREE
ERHRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGR
ESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDL
LEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALA
REGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFL
LLTVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLY
PASGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKL
FFV
B:  LGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVY
PLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARMG
QTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRR
LEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAF
LLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWE
LLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAW
VADPKKPIPHLTGLLVPVLTLEDLHEEGSLALSLPWEERR
RRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGRRAV
SKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLR
AFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVL
VLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRW
ENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRESFRF
GGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLEETL
WAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALAREGIA
YDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVH
RDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGF
AFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFFV
C:  TGAGGTAGTAGGTTGT
D:  TACTACCTCG
E:  TGAGGTAGTAGGTTGT
F:  TACTACCTCG
G:  ACAACC
H:  ACAACC
Description


Functional site

1) chain A
residue 195
type
sequence N
description BINDING SITE FOR RESIDUE DT A 701
source : AC1

2) chain A
residue 197
type
sequence Y
description BINDING SITE FOR RESIDUE DT A 701
source : AC1

3) chain A
residue 200
type
sequence R
description BINDING SITE FOR RESIDUE DT A 701
source : AC1

4) chain A
residue 217
type
sequence L
description BINDING SITE FOR RESIDUE DT A 701
source : AC1

5) chain A
residue 218
type
sequence P
description BINDING SITE FOR RESIDUE DT A 701
source : AC1

6) chain A
residue 223
type
sequence L
description BINDING SITE FOR RESIDUE DT A 701
source : AC1

7) chain A
residue 226
type
sequence Y
description BINDING SITE FOR RESIDUE DT A 701
source : AC1

8) chain A
residue 227
type
sequence H
description BINDING SITE FOR RESIDUE DT A 701
source : AC1

9) chain A
residue 232
type
sequence R
description BINDING SITE FOR RESIDUE DT A 701
source : AC1

10) chain A
residue 254
type
sequence I
description BINDING SITE FOR RESIDUE DT A 701
source : AC1

11) chain A
residue 255
type
sequence P
description BINDING SITE FOR RESIDUE DT A 701
source : AC1

12) chain A
residue 256
type
sequence H
description BINDING SITE FOR RESIDUE DT A 701
source : AC1

13) chain B
residue 37
type
sequence P
description BINDING SITE FOR RESIDUE DT A 701
source : AC1

14) chain B
residue 38
type
sequence G
description BINDING SITE FOR RESIDUE DT A 701
source : AC1

15) chain B
residue 39
type
sequence R
description BINDING SITE FOR RESIDUE DT A 701
source : AC1

16) chain A
residue 478
type
sequence D
description BINDING SITE FOR RESIDUE MG A 702
source : AC2

17) chain A
residue 479
type
sequence A
description BINDING SITE FOR RESIDUE MG A 702
source : AC2

18) chain A
residue 546
type
sequence D
description BINDING SITE FOR RESIDUE MG A 702
source : AC2

19) chain D
residue 10
type
sequence T
description BINDING SITE FOR RESIDUE MG A 702
source : AC2

20) chain G
residue 6
type
sequence C
description BINDING SITE FOR RESIDUE MG A 702
source : AC2

21) chain A
residue 37
type
sequence P
description BINDING SITE FOR RESIDUE DT B 701
source : AC3

22) chain A
residue 38
type
sequence G
description BINDING SITE FOR RESIDUE DT B 701
source : AC3

23) chain A
residue 39
type
sequence R
description BINDING SITE FOR RESIDUE DT B 701
source : AC3

24) chain B
residue 195
type
sequence N
description BINDING SITE FOR RESIDUE DT B 701
source : AC3

25) chain B
residue 197
type
sequence Y
description BINDING SITE FOR RESIDUE DT B 701
source : AC3

26) chain B
residue 200
type
sequence R
description BINDING SITE FOR RESIDUE DT B 701
source : AC3

27) chain B
residue 217
type
sequence L
description BINDING SITE FOR RESIDUE DT B 701
source : AC3

28) chain B
residue 218
type
sequence P
description BINDING SITE FOR RESIDUE DT B 701
source : AC3

29) chain B
residue 223
type
sequence L
description BINDING SITE FOR RESIDUE DT B 701
source : AC3

30) chain B
residue 226
type
sequence Y
description BINDING SITE FOR RESIDUE DT B 701
source : AC3

31) chain B
residue 227
type
sequence H
description BINDING SITE FOR RESIDUE DT B 701
source : AC3

32) chain B
residue 232
type
sequence R
description BINDING SITE FOR RESIDUE DT B 701
source : AC3

33) chain B
residue 254
type
sequence I
description BINDING SITE FOR RESIDUE DT B 701
source : AC3

34) chain B
residue 255
type
sequence P
description BINDING SITE FOR RESIDUE DT B 701
source : AC3

35) chain B
residue 256
type
sequence H
description BINDING SITE FOR RESIDUE DT B 701
source : AC3

36) chain B
residue 478
type
sequence D
description BINDING SITE FOR RESIDUE MG B 702
source : AC4

37) chain B
residue 660
type
sequence D
description BINDING SITE FOR RESIDUE MG B 702
source : AC4

38) chain F
residue 10
type
sequence T
description BINDING SITE FOR RESIDUE MG B 702
source : AC4

39) chain B
residue 478
type
sequence D
description BINDING SITE FOR RESIDUE MG B 703
source : AC5

40) chain B
residue 479
type
sequence A
description BINDING SITE FOR RESIDUE MG B 703
source : AC5

41) chain B
residue 546
type
sequence D
description BINDING SITE FOR RESIDUE MG B 703
source : AC5

42) chain F
residue 10
type
sequence T
description BINDING SITE FOR RESIDUE MG B 703
source : AC5

43) chain H
residue 9
type
sequence C
description BINDING SITE FOR RESIDUE MG B 703
source : AC5

44) chain A
residue 685
type
sequence V
description BINDING SITE FOR RESIDUE MG C 101
source : AC6

45) chain C
residue 1
type
sequence T
description BINDING SITE FOR RESIDUE MG C 101
source : AC6

46) chain C
residue 3
type
sequence A
description BINDING SITE FOR RESIDUE MG C 101
source : AC6

47) chain A
residue 478
type
sequence D
description BINDING SITE FOR RESIDUE MG D 101
source : AC7

48) chain A
residue 660
type
sequence D
description BINDING SITE FOR RESIDUE MG D 101
source : AC7

49) chain D
residue 10
type
sequence T
description BINDING SITE FOR RESIDUE MG D 101
source : AC7

50) chain B
residue 685
type
sequence V
description BINDING SITE FOR RESIDUE MG E 101
source : AC8

51) chain E
residue 1
type
sequence T
description BINDING SITE FOR RESIDUE MG E 101
source : AC8

52) chain E
residue 3
type
sequence A
description BINDING SITE FOR RESIDUE MG E 101
source : AC8

53) chain A
residue 478
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI1

54) chain A
residue 546
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI1

55) chain A
residue 660
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI1

56) chain B
residue 478
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI1

57) chain B
residue 546
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI1

58) chain B
residue 660
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI1

59) chain A
residue 512
type ACT_SITE
sequence E
description ACT_SITE => ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI2

60) chain B
residue 512
type ACT_SITE
sequence E
description ACT_SITE => ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI2

61) chain A
residue 478
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI3

62) chain B
residue 478
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI3

63) chain A
residue 546
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI4

64) chain A
residue 660
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI4

65) chain B
residue 546
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI4

66) chain B
residue 660
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI4

67) chain A
residue 685
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI5

68) chain B
residue 685
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI5


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