eF-site ID 4n9f-S
PDB Code 4n9f
Chain S

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Title Crystal structure of the Vif-CBFbeta-CUL5-ElOB-ElOC pentameric complex
Classification LIGASE/VIRAL PROTEIN
Compound Cullin-5
Source Homo sapiens (Human) (Q72499_9HIV1)
Sequence S:  NRWQVMIVWQVDRMRINTWKRLVKHHMYISRKAKDWFYRH
HYESTNPKISSEVHIPLGDAKLVITTYWGLHTGERDWHLG
QGVSIEWRKKRYSTQVDPDLADQLIHLHYFDCFSESAIRN
TILGRIVSPRCEYQAGHNKVGSLQYLALAALIKPKQIKPP
LPSVRKLTED
Description


Functional site

1) chain S
residue 108
type
sequence H
description BINDING SITE FOR RESIDUE ZN S 201
source : AC4

2) chain S
residue 114
type
sequence C
description BINDING SITE FOR RESIDUE ZN S 201
source : AC4

3) chain S
residue 133
type
sequence C
description BINDING SITE FOR RESIDUE ZN S 201
source : AC4

4) chain S
residue 134
type
sequence E
description BINDING SITE FOR RESIDUE ZN S 201
source : AC4

5) chain S
residue 139
type
sequence H
description BINDING SITE FOR RESIDUE ZN S 201
source : AC4

6) chain S
residue 151
type SITE
sequence L
description Cleavage in virion (by viral protease) => ECO:0000255|HAMAP-Rule:MF_04081
source Swiss-Prot : SWS_FT_FI1

7) chain S
residue 96
type MOD_RES
sequence T
description Phosphothreonine; by host MAP4K1 => ECO:0000255|HAMAP-Rule:MF_04081
source Swiss-Prot : SWS_FT_FI2

8) chain S
residue 145
type MOD_RES
sequence S
description Phosphoserine; by host => ECO:0000255|HAMAP-Rule:MF_04081
source Swiss-Prot : SWS_FT_FI3

9) chain S
residue 166
type MOD_RES
sequence S
description Phosphoserine; by host MAP4K1 => ECO:0000255|HAMAP-Rule:MF_04081
source Swiss-Prot : SWS_FT_FI4


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